Dr Fu Wai-chung Research Assistant Professor

Location Y824-07
Phone +852 3400 8684
mail waichung.fu@polyu.edu.hk

Open Platform for University Scholars
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Education and Academic Qualifications Doctor of Philosophy, The Hong Kong Polytechnic University
Bachelor of Science in Chemistry, Hong Kong Baptist University




Research Overview Our research focuses on streamlined continuous-flow synthesis of active pharmaceutical ingredients such as anti-cancer agents and antibiotics. We are also interested in using the many attributes of flow chemistry to enable new reactions which would otherwise be difficult or improbable to achieve previously under regular organic synthesis conditions.




Academic and Professional Experiences Member of American Chemical Society




Research Interests
Transition Metal Catalysis
Flow Chemistry
Organic Chemistry
Catalyst Design



Achievements

Awards
2018Croucher Fellowship for Postdoctoral Research, The Croucher Foundation, Hong Kong
2017SciFinder Future Leaders Award, Chemical Abstracts Service, American Chemical Society
2017HKSAR Government Scholarship – Reaching Out Award
2017Best Poster Award for Organic Chemistry, The 24thSymposium on Chemistry Postgraduate Research in Hong Kong
2016Best Oral Presentation Award, The 6thJunior International Conference on Cutting-edge Organic Chemistry in Asia
2016Best Poster Presentation for Organic Chemistry, The 23rdSymposium on Chemistry Postgraduate Research in Hong Kong
2015First Prize of Oral Presentation, The 22ndSymposium on Chemistry Postgraduate Research in Hong Kong
2013 Best Undergraduate Research Project, Department of Chemistry, Hong Kong Baptist University




Patents
Kwong, F. Y.;Fu, W. C.;To, S. C.; So, C. M.; Choy, P. Y. "Preparation of Carbazolyl-based Phosphine Ligands and Applications Thereof"CN patent2017, CN106588983 (A)




Representative Publications
Fu, W. C.; MacQueen, P. M.; Jamison, T. F.* “Continuous Flow Strategies for Using Fluorinated Greenhouse Gases in Fluoroalkylations” Chem. Soc. Rev. 2021, doi.org/10.1039/D0CS00670J
Fu, W. C.; Jamison, T. F.* “Deuteriodifluoromethylation and gem-Difluoroalkenylation of Aldehydes Using ClCF₂H in Continuous Flow” Angew. Chem. Int. Ed. 2020, 59, 13885.(Selected as Synfact of the Month by Synfacts 2020, 16, 1001.)
Fu, W. C.; Kwong, F. Y.* “A Denitrogenative Palladium-Catalyzed Cascade for Regioselective Synthesis of Fluorenes” Chem. Sci. 2020, 11, 1411.
Fu, W. C.; Jamison, T. F.* “Modular Continuous Flow Synthesis of Imatinib and Analogues” Org. Lett. 2019, 21, 6112.(Highlighted by Synfacts 2019, 15, 1213.)
Zhao, Q; Fu, W. C.*; Kwong, F. Y.* “Palladium-Catalyzed Regioselective Aromatic Extension of Internal Alkynes through a Norbornene-Controlled Reaction Sequence” Angew. Chem. Int. Ed. 2018, 57, 3381.(Highlighted by Synfacts 2018, 14, 0370.)
Fu, W. C.; Zheng, B; Zhao, Q.; Chan, W. T. K.; Kwong, F. Y.* “Cascade Amination and Acetone Monoarylation with Aryl Iodides by Palladium/Nobornene Cooperative Catalysis” Org. Lett. 2017, 19, 4335.
Fu, W. C.; Wang, Z.; Chan, W. T. K.; Lin, Z.*; Kwong, F. Y.* “Regioselective Synthesis of Polycyclic and Heptagon-embedded Aromatic Compounds through a Versatile π-Extension of Aryl Halides” Angew. Chem. Int. Ed. 2017, 56, 7166.
Fu, W. C.; So, C. M.; Yuen, O. Y.; Lee, I. T. C.; Kwong, F. Y.* “Exploiting Aryl Mesylates and Tosylates in Catalytic Mono-a-Arylation of Aryl- and Heteroarylketones” Org. Lett. 2016, 18, 1872. (Highlighted in Organic Chemistry Portal)
Fu, W. C.; So, C. M.; Kwong, F. Y.* “Palladium-Catalyzed Phosphorylation of Aryl Mesylates and Tosylates” Org. Lett. 2015, 17, 5906.(Highlighted in Organic Chemistry Portal)
Fu, W. C.; So, C. M.; Chow, W. K.; Yuen, O. Y.; Kwong, F. Y.* “Design of an Indolylphosphine Ligand for Reductive Elimination-Demanding Monoarylation of Acetone Using Aryl Chlorides” Org. Lett. 2015, 17, 4612.(Highlighted in Organic Chemistry Portal)