Dr Keng Wee-keong, Vincent DoCAF & Assoc. Professor

Location Y803
Phone +852 3400 8728
mail vincent.keng@polyu.edu.hk

Open Platform for University Scholars
ORCID ID
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Education and Academic Qualifications Doctor of Philosophy, Fukui Medical University




Research Overview Our research group focuses on elucidating the genetic mechanisms of various types of human cancers. The information obtained will translate to better disease prevention, diagnosis and establishing effective therapeutic regimes.




Research Interests
Cancer
Genetics
Molecular Biology



Achievements

Representative Publications
To, J.C., Chiu, A.P., Tschida, B.R., Lo, L.H., Chiu, C.H., Li, X.X., Kuka, T.P., Linden, M.A., Amin, K., Chan, W.C., Bell, J.B., Moriarity, B.S., Largaespada, D.A.** & Keng, V.W.** (2021) ZBTB20 regulates WNT/CTNNB1 signaling pathway by suppressing PPARG during hepatocellular carcinoma tumourigenesis. JHEP Reports. 3, 100223. [https://doi.org/10.1016/j.jhepr.2020.100223].

Li, X.X., Zhang, S.J., Man, K.Y., Chiu, A.P., Lo, L.H., To, J.C., Chiu, C.H., Chan, C.O., Mok, D.K.W., Rowlands, D.K. & Keng, V.W.* (2020) Schwann cell-specific Pten inactivation reveals essential role of the sympathetic nervous system activity in adipose tissue development. Biochem. Biophys. Res. Comm. 531, 118-124.
Conboy, C.B., Vélez-Reyes, G.L., Tschida, B.R., Hu, H., Kaufmann, G., Koes, N., Keller, B., Alsinet, C., Cornellà, H., Pinyol, R., Abrahante, J.E., Temiz, N.A., Linden, M.A., Amin, K., Kuka, T.P., Keng, V.W., Llovet, J.M., Starr, T.K. & Largaespada, D.A. (2019) RSPO2 drives liver tumor development in a YAP-dependent manner. Hepatology Comm. 3, 1496-1509.
Zhang, S.J., Li, X.X., Yu, Y., Chiu, A.P., Lo, L.H., To, J.C., Rowlands, D.K. & Keng, V.W.* (2019) Schwann cell-specific PTEN and EGFR dysfunctions affect neuromuscular junction development by impairing Argrin signaling and autophagy. Biochem. Biophys. Res. Comm. 515, 50-56.
Chiu, A.P., Tschida, B.R., Sham, T.T., Lo, L.H., Moriarity, B.S., Li, X.X., Lo, R.C., Hinton, D.E., Rowlands, D.K., Chan, C.O., Mok, D.K.W., Largaespada, D.A., Warner, N. & Keng, V.W.* (2019) HBx-K130M/V131I promotes liver cancer in transgenic mice via AKT/FOXO1 signaling pathway and arachidonic acid metabolism. Mol. Cancer Res. 17, 1582-1593.
Li, X.X., Lu, X.Y., Zhang, S.J., Chiu, A.P., Lo, L.H., Largaespada, D.A., Chen, Q.B.** & Keng, V.W.** (2019) Sodium tanshinone IIA sulfonate ameliorates hepatic steatosis by inhibiting lipogenesis and inflammation. Biomed. Pharmacother. 111, 68-75.
Chiu, A.P. & Keng, V.W.* (2019) Liver-specific delivery of Sleeping Beauty transposon system by hydrodynamic injection for cancer gene validation. Methods Mol. Biol. 1907, 185-196.
Li, X.X., Zhang, S.J., Chiu, A.P., Lo, L.H., To, J.C., Cui, H.N. & Keng, V.W.* (2019) Conditional inactivation of Nf1 and Pten in Schwann cells results in abnormal neuromuscular junction maturation. G3 (Bethesda) 9, 297-303.
Li, X.X., Zhang, S.J., Chiu, A.P., Lo, L.H., Huang, J., Rowlands, D.K., Wang, J. & Keng, V.W.* (2018) Targeting of AKT/ERK/CTNNB1 by DAW22 as a potential therapeutic compound for malignant peripheral nerve sheath tumor. Cancer Med. 7, 4791-4800.
Riordan, J.D., Feddersen, C.R., Tschida, B.R., Beckmann, P.J., Keng, V.W., Linden, M.A., Amin, K., Stipp, C.S., Largaespada, D.A. & Dupuy, A.J. (2018) Chronic liver injury alters driver mutation profiles in hepatocellular carcinoma in mice. Hepatology. 67, 924-939.
Tschida, B.R., Temiz, A., Kuka, T.P. Lee, L.A., Riordan, J.D., Tierrablanca, C.A., Hullsiek, R., Wagner, S., Hudson, W.A., Linden, M.A., Amin, K., Beckmann, P.J., Heuer, R.A., Sarver, A.L. Yang, J.D., Roberts, L.R., Nadeau, J.H., Dupuy, A.J., Keng, V.W.**, & Largaespada, D.A.** (2017) Sleeping Beauty insertional mutagenesis in mice identifies steatosis-associated hepatic tumor drivers. Cancer Res. 77, 6576-6588.
Wu, J., Keng, V.W., Patmore, D.M., Kendall, J.J., Patel, A.V., Jousma, E., Jessen, W.J., Choi, K., Tschida, B.R., Silverstein, K.A.T., Fan, D., Schwartz, E.B., Fuchs, J.R., Zou, Y., Kim, M., Dombi, E., Levy, D.E., Huang, G., Cancelas, J.A., Stemmer-Rachanimov, A.O., Spinner, R.J., Largaespada, D.A. & Ratner, N. (2016) Insertional mutagenesis identifies a STAT3/Arid1a/ß-catenin pathway driving neurofibroma initiation. Cell Rep. 14, 1979-1990.