Dr Lee Man-yuen, Leo Research Assistant Professor

Location Y824-03
Phone +852 3400 8881
mail man-yuen.lee@polyu.edu.hk

Open Platform for University Scholars
ORCID ID
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Education and Academic Qualifications Doctor of Philosophy, The Chinese University of Hong Kong
Master of Philosophy, The Chinese University of Hong Kong
Bachelor of Science in Applied Biology with Biotechnology, The Hong Kong Polytechnic University




Research Overview My research focuses on (1) development of drugs for prevention and treatment of obesity-related metabolic disorders and cancer, and aging-related diseases; (2) development of in utero therapeutic interventions to combat against the adverse effects of maternal diabetes and obesity on fetal development.




Teaching Area Experimental Approach To Molecular Biology And Biochemistry

Human Physiology







Research Interests
Drug Development
Metabolic Disorder
Fetal Intervention



Achievements

Representative Publications
. Lee LMY, Tam STK, McCaffery PJ and Shum ASW (2019). Highly sensitive quantitative determination of retinoic acid levels, retinoic acid synthesis, and catabolism in embryonic tissue using a reporter cell-based method. In: Ray SK (eds)Retinoid and Rexinoid Signaling.Methods and Protocols.Methods in Molecular Biologyvol 2019, p.181-192, Humana Press, New York
.Lee LMY, Leung MBW, Kwok RCY, Leung YC, Wang CC, McCaffery PJ, Copp AJ andShum ASW(2017). Perturbation of retinoid homeostasis increases malformation risk in embryos exposed to pregestational diabetes.Diabetes66, 1041-1051.
.Lee LMY, Leung CY, Tang WWC, Choi HL, Leung YC, McCaffery PJ, Wang CC, Woolf AS and Shum ASW (2012).A paradoxical teratogenic mechanism forretinoic acid.Proc Natl Acad SciUSA109, 13668–13673.




Patent
Methods for Inducing Intermittent Fasting and Modulating Autophagy (US Provisional Application for Patent No. 62/942,354. Filed on 2 Dec 2019)