Dr Ma Cong Assistant Professor

Location Y853
Phone +852 3400 8810
mail cong.ma@polyu.edu.hk

Open Platform for University Scholars
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Education and Academic Qualifications Doctor of Philosophy in Chemistry, école polytechnique
Master of Science in Molecular Chemistry, école polytechnique
Bachelor of Science in Medicinal Chemistry, China Pharmaceutical University
Massachusetts Institute of Technology




Professional Qualifications Licensed Pharmacist (China)
Registered Pharmacist (Australia)




Research Overview The research in our group focuses on drug discovery as well as related topics in organic chemistry and molecular pharmacology.




Academic and Professional Experiences American Chemical Society
Chinese Chemical Society




Research Interests
Drug Discovery
Synthetic Organic Chemistry and Catalysis
Mechanism of Drug Action



Achievements

Awards
2019Global Innovation Award, TechConnect World Innovation Conference & Expo
2019Honorary KTP Visiting Fellowship, University of Technology, Sydney
2014-2015 Faculty Early Career Research Award, University of Newcastle
2009-2010 EDX Postdoctoral Research Fellowship, Ecole Polytechnique
2005-2008 EGIDE Postgraduate Research Fellowship, French Ministry of Foreign Affairs




Patents
N-Substituted oseltamivir derivatives with antimicrobial activity (WO2020259471A1);
Compounds with antimicrobial activity (WO2020001321A1, CN112638909A);
Compounds with antimicrobial activity (WO2019138323A1, EP3737664A1, JP2021510143A, US2A1, CN111971271A)




Representative Publications
Ye J, Chu AJ, Harper R, Chan ST, Shek TL, Zhang Y, Ip M, Sambir M, Artsimovitch I, Zuo Z, Yang X,Ma C. (2020) Discovery of Antibacterials that Inhibit Bacterial RNA Polymerase Interactions with Sigma Factors.Journal of Medicinal Chemistry63, 7695–7720. (Supplementary Journal Cover)
Liu Y, Lam LY, Ye J, Blanchard N,Ma C. (2020) DABCO‐promoted diaryl thioether formation by metal‐catalyzed coupling of sodium sulfinates and aryl iodides.Advanced Synthesis & Catalysis362, 2326-2331. (Highlighted byOrganic Process Research & Development: "Some Items of Interest to Process R&D Chemists and Engineers" 2020, 24, 6, 885–896.)
Qiu Y, Chan ST, Lin L, Shek TL, Tsang TF, Zhang Y, Ip M, Chan PKS, Blanchard N, Hanquet G, Zuo Z, Yang X,Ma C. (2019) Nusbiarylins, a New Class of Antimicrobial Agents: Rational Design of Bacterial Transcription Inhibitors Targeting the Interaction between the NusB and NusE Proteins.Bioorganic Chemistry92, 103203.
Qiu Y, Chan ST, Lin L, Shek TL, Tsang TF, Barua N, Zhang Y, Ip M, Chan PKS, Blanchard N, Hanquet G, Zuo Z, Yang X,Ma C. (2019) Design, synthesis and biological evaluation of antimicrobial diarylimine and –amine compounds targeting the interaction between the bacterial NusB and NusE proteins.European Journal of Medicinal Chemistry178, 214–231.
Yang X, Luo MJ, Yeung ACM, Lewis PJ, Chan PKS, Ip M,Ma C. (2017) First-In-Class Inhibitor of Ribosomal RNA Synthesis with Antimicrobial Activity againstStaphylococcus aureus.Biochemistry56, 5049–5052.
Ma C, Yang X, Lewis PJ. (2016) Bacterial Transcription Inhibitor of RNA Polymerase Holoenzyme Formation by Structure-Based Drug Design: Fromin SilicoScreening to Validation.ACS Infectious Diseases2, 39–46.
Ma C, Yang X, Lewis PJ. (2016) Bacterial transcription as a target for antibacterial drug development.Microbiology and Molecular Biology Reviews80, 139–160.
Ma C, Letort A, Aouzal R, Wilkes A, Maiti G, Farrugia LJ, Ricard L, Prunet J. (2016) Cascade Metathesis Reactions for the Synthesis of Taxane and Isotaxane Derivatives.Chemistry - A European Journal22, 6891–6898.
Ma C, Mobli M, Yang X, Keller A, King G, Lewis PJ. (2015) RNA polymerase-induced remodelling of NusA produces a pause enhancement complex.Nucleic Acids Research43, 2829–2840.
Letort A, Aouzal R,Ma C, Long DL, Prunet J. (2014) Highly Efficient Synthesis of the Tricyclic Core of Taxol by Cascade Metathesis.Organic Letters16, 3300–3303.