Dr Tsoi Bun Research Assistant Professor

Location Y824-04
Phone +852 3400 8714
mail bun.tsoi@polyu.edu.hk

Open Platform for University Scholars
ORCID ID
SCOPUS ID









Education and Academic Qualifications Doctor of Medicine, Jinan University
Master of Science, Jinan University




Research Overview My research is mainly related to the pharmacological study of herbal medicine and its active compounds in various neurological diseases, such as stroke and depression, using animal and cellular model.




Academic and Professional Experiences Member of World Federation of Chinese Medicine Societies




Research Interests
Neuroscience and Neuropharmacology
Post-stroke therapy
Depression
Active compound screening
traditional Chinese medicine



Achievements

Patents
1. Shen J., Chen H., Tsoi B., Wu W., & Li X. Kit combating ischemic stroke and use thereof. WO2019127672A1, CN109954112A




Representative Publications
First authorship
1. Tsoi, B., Chen, X., Gao, C., Wang, S., Yuen, S. C., Yang, D., & Shen, J. “Neuroprotective Effects and Hepatorenal Toxicity of Angong Niuhuang Wan Against Ischemia–Reperfusion Brain Injury in Rats.” Frontiers in pharmacology 10 (2019): 593.
2. Tsoi, B., Wang, S., Gao, C., Luo, Y., Li, W., Yang, D., Yang, D. & Shen, J. “Realgar and cinnabar are essential components contributing to neuroprotection of Angong Niuhuang Wan with no hepatorenal toxicity in transient ischemic brain injury.” Toxicology and Applied Pharmacology, 337, (2019): 114613.
3. Tsoi, B., Yi, R. N., Cao, L. F., Li, S. B., Tan, R. R., Chen, M., Li, X. X., Wang, C., Li, Y. F., Kurihara, H. & He, R. R. “Comparing antioxidant capacity of purine alkaloids: A new, efficient trio for screening and discovering potential antioxidants in vitro and in vivo.” Food Chemistry, 176, (2015): 411-419.
4. Tsoi, B., He, R. R., Yang, D. H., Li, Y. F., Li, X. D., Li, W. X., Abe, K. & Kurihara, H. “Carnosine ameliorates stress-induced glucose metabolism disorder in restrained mice.” Journal of Pharmacological Sciences, 117, (2011): 223-229.
5. He, R. R., Tsoi, B., Lan, F., Yao, N., Yao, X. S., & Kurihara, H. “Antioxidant properties of lutein contribute to the protection against lipopolysaccharide-induced uveitis in mice.” Chinese Medicine 6 (2011): 38. (Co-first author)
Co-authorship
6. Du, Q., Deng, R., Li, W., Zhang, D., Tsoi, B., & Shen, J. “Baoyuan Capsule promotes neurogenesis and neurological functional recovery through improving mitochondrial function and modulating PI3K/Akt signaling pathway.”Phytomedicine,93, (2021): 153795.
7. He, Y., Chen, S., Tsoi, B., Qi, S., Gu, B., Wang, Z., Peng, C., & Shen, J. “Alpinia oxyphylla Miq. and Its Active Compound P-Coumaric Acid Promote Brain-Derived Neurotrophic Factor Signaling for Inducing Hippocampal Neurogenesis and Improving Post-cerebral Ischemic Spatial Cognitive Functions.”Frontiers in cell and developmental biology8 (2021): 577790.
8. Li, W., Feng, J., Gao, C., Wu, M., Du, Q., Tsoi, B., Wang, Q., Yang, D., & Shen, J. “Nitration of Drp1 provokes mitophagy activation mediating neuronal injury in experimental autoimmune encephalomyelitis.” Free Radical Biology and Medicine 143 (2019): 70-83.
9. Tan, R. R., Li, Y. F., Zhang, S. J., Huang, W. S., Tsoi, B., Hu, D., Wan. X., Yang, X. Wang, Q., Kurihara, H., & He, R. R. “Abnormal O-GlcNAcylation of Pax3 Occurring from Hyperglycemia-Induced Neural Tube Defects Is Ameliorated by Carnosine But Not Folic Acid in Chicken Embryos.” Molecular Neurobiology 54 (2017): 281-294.
10. Duan, W. J., Li, Y. F., Liu, F. L., Deng, J., Wu, Y. P., Yuan, W. L., Tsoi, B., Chen, J. L., Wang, Q., Cai, S. H., Kurihara, H. & He, R. R."A SIRT3/AMPK/autophagy network orchestrates the protective effects of trans-resveratrol in stressed peritoneal macrophages and RAW 264.7 macrophages." Free Radical Biology and Medicine 95 (2016): 230- 242. IF 7.376