Dr Wong Wing-yan Research Assistant Professor

Location Y824-02
Phone +852 3400 8884
mail wyan.wong@polyu.edu.hk

Open Platform for University Scholars
ORCID ID
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Education and Academic Qualifications Doctor of Philosophy, Hong Kong Baptist University




Research Overview Functional role of gut microbiota in gastrointestinal cancers and inflammatory bowel disease.Mechanistic study of exosome in gastrointestinal cancers and inflammatory bowel disease.




Academic and Professional Experiences Review Editor (Frontiers in Pharmacology)
The Chinese Medicine Council of Hong Kong, Department of Health





Research Interests
Gut Microbiota
Cancer
Inflammatory Bowel Diseases
Herbal Formula



Achievements

Patents
Compounds, compositions and methods for the preparation of peptide/protein conjugates. Li, X., Tung, C. L.,Wong, C. T. T.US9752137B2, CN104877982B




Representative Publications
Chu, J. C. H., Chin, M. L.,Wong, C. T. T.*, Hui, M.*, Lo, P. C.*, Ng, D. K. P.* One-Pot Synthesis of a Cyclic Antimicrobial Peptide-Conjugated Phthalocyanine for Synergistic Chemo-Photodynamic Killing of Multidrug-Resistant Bacteria.Adv. Therap.2020, 2000204.
Chu, J. C. H., Yang, C., Fong, W. P., Wong, C. T. T.*, Ng, D. K. P.* Facile One-Pot Synthesis of Cyclic Peptide-Conjugated Photosensitiser For Targeted Photodynamic Therapy. Chem. Commun. 2020, 55, 11941.
Wong, C. T. T.*, Chu J. C. H., Ha, S. Y. Y., Wong, R. C. H., Dai, G., Kwong, T. T., Wong, C. H., Ng, D. K. P.* Phthalaldehyde-Amine Capture Reaction For Bioconjugation and Immobilization of Phthalocyanines.Org. Lett.2020, 22, 7098.
Zhang, Y., Zhang, Q.,Wong, C. T. T., Li, X. Chemoselective Peptide Cyclization and Biocyclization Directly on Unprotected Peptides.J. Am. Chem. Soc.2019, 141.12274.
Lee, C. L., Liu, H.Wong, C. T. T., Chow, H. Y. and Li, X. Enabling N-to-C Ser/Thr Ligation for Convergent Protein Synthesis via Combining Chemical Ligation Approaches.J. Am. Chem. Soc.2016, 138, 10477-10484.
Tung, C. L.,Wong, C. T. T., Fung, E. Y. M. and Li, X. Traceless and Chemoselective Amine Bioconjugation via Phthalimidine Formation in Native Protein Modification.Org. Lett.2016, 18, 2600-2603.
Wong, C. T. T., Lam, H. Y., Song, T., Chen, G. and Li, X. Synthesis of Constrained Head-to- Tail Cyclic Tetrapeptides by Imine-Induced Ring-Closing/Contraction Strategy.Angew. Chem. Int. Ed.2013, 52, 10212-10215.
Lam, H. Y., Zhang, Y., Liu, H., Xu, J.,Wong, C. T. T.,Xu, C. and Li, X. Total Synthesis of Daptomycin by Cyclization via a Chemoselective Serine Ligation.J. Am. Chem. Soc.2013, 135, 6272-6279.
Wong. C. T. T., Rowlands, D. K., Wong, C. H., Lo, T. W. C., Nguyen, G. K. T., Li, H, Y., Tam, J. P. Orally Active Peptidic Bradykinin B1 Receptor Antagonists Engineered from a Cyclotide Scaffold for Inflammatory Pain Treatment.Angew. Chem. Int. Ed.2012, 51, 5620