Dr Zhang Huan Research Assistant Professor

Location Y824-06
Phone +852 3400 8758
mail zhanghuan.zhang@polyu.edu.hk

ORCID ID
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Education and Academic Qualifications Master of Medicine, Guangzhou University of Traditional Chinese Medicine
Master of Science in Chinese Medicinal Sciences, University of Macau
Bachelor of Science in Clinical Traditional Chinese Medicine, Henan University of Traditional Chinese Medicine




Professional Qualifications Registered Chinese Medicine Practitioner in Hong Kong



Research Overview (1) Drug R&D from TCM for Treating Neurodegenerative Diseases and Nonalcoholic Fatty Liver
(2) Molecular/cellular Mechanisms of Neurodegenerative Diseases and Nonalcoholic Fatty Liver




Research Interests
Traditional Chinese Medicine
Nonalcoholic Fatty Liver
Neurodegenerative Diseases
Parkinson’s disease



Achievements

Awards and Patents
Chan, S. W.; Lam, K.H; Zhang H; Ng, Y. F. Quinoline dimer as well as preparation method and application thereof. Shen Zhen Research Institute, The Hong Kong Polytechnic University. CN 109535075B. Granted Date: 08/07/2020
2 Li X.H.; Dong X. H.; Zhao Q.; Zhang H. Application of triterpene compound and Parkinson's disease treatment medicine. Shen Zhen Research Institute, The Hong Kong Polytechnic University. CN106581006, Granted Date:29/11/2019




Representative Publications
Xu S*. Zhang, H.*, Cheng S.H., Chen., X.P. (2021). Cannabidiol promotes fin regeneration and reduces apoptosis in zebrafish embryos. Journal of functional foods. (Under revision). * The authors contributed equally to this work.
Xu S. Zhang, H., Pao P. C. , Lee Audrey., Wang, J., Chan Yu Suen., Chan, S.W., Cheng S.H., Chen., X.P. (2020) Exposure to phthalates impaired neurodevelopment through estrogenic effects and induced DNA damage in neurons. Aquatic Toxicology 222 (2020) 105469
Zhang, H., Zhou, X., Wong, M. H. Y., Man, K. Y., Pin, W. K., Yeung, J. H. K., Kwan,Y. W., Leung, G. P. H., Ho, P. M., Lee, S. M. Y., Chan, C. O., Mok, D. K. W., Yu, P. H. F., and Chan, S. W. (2017) Sichuan pepper attenuates H2O2-induced apoptosis via antioxidant activity and up-regulating heme oxygenase-1 gene expression in primary rat hepatocytes. Journal of Food Biochemistry e12403, 1-10
Zhang, H., Wu, M. Y., Guo, D. J., Wan, C. W., and Chan, S. W. (2017) Gui‐ling‐gao inhibits Concanavalin A‐induced inflammation by suppressing the expressions of iNOS and proinflammatory cytokines in mice isolated splenocytes. Journal of Food Biochemistry, 1-7
Sham, T. T., Li, M. H., Chan, C. O., Zhang, H., Chan, S. W., and Mok, D. K. W. (2017) Cholesterol-lowering effects of piceatannol, a stilbene from wine, using untargeted metabolomics. Journal of Functional Foods 28, 127-137
Li, J. J., Zhou, S. Y., Zhang, H., Lam, K. H., Lee, S. M. Y., Yu, P. H. F., and Chan, S. W. (2015) Cortex Fraxini (Qingpi) protects rat pheochromocytoma cells against 6-hydroxydopamine-induced apoptosis. Parkinson’s Disease 2015, 1-10
Zhang, H., Li, C., Kwok, S. T., Zhang, Q. W., and Chan, S. W. (2013) A review of the pharmacological effects of the dried root of Polygonum cuspidatum (Hu Zhang) and its constituents. Evidence-based complementary and alternative medicine 2013, 208349
Zhang, H., Wu, M. Y., Guo, D. J., Wan, C. W., Lau, C. C., Chan, C. O., Mok, D. K. W., and Chan, S. W. (2013) Gui-ling-gao (turtle jelly), a traditional Chinese functional food, exerts anti-inflammatory effects by inhibiting iNOS and pro-inflammatory cytokine expressions in splenocytes isolated from BALB/c mice. Journal of Functional Foods 5, 625-632
Zhang H, Qing-Wen Zhang , Lei Wang, Xiao-Qi Zhang, Wen-Cai Yecd and Yi-Tao Wang. (2012) Two new anthraquinone malonylglucosides from Polygonum cuspidatum. Natural Product Research.26(14):1323-7
Zhang H, Mak SH, Cui W, Li WM, Han RW, Hu SQ, Ye MZ, Pi RB, Han YF. (2011) Tacrine(2)-ferulic acid, a novel multifunctional dimer, attenuates 6-hydroxyldopamine-induced apoptosis in PC12 cells by activating Akt pathway. Neurochemistry International. 59(7):981-8.