Dr Zhao Qian Assistant Professor

Location Y846
Phone +852 3400 8711
mail q.zhao@polyu.edu.hk
stream Lab Webpage

Open Platform for University Scholars
ORCID ID
SCOPUS ID









Education and Academic Qualifications Doctor of Philosophy, The University of Hong Kong
Bachelor of Engineering, Xi'an Jiaotong University




Research Overview (1) To study the mechanisms and to facilitate the development of innovative anticancer molecules.
(2) To develop novel chemical proteomic approaches for studying fundamental biology.
(3) To investigate novel functional peptides, including cytosolic peptides and immuopeptides, particularly those encoded by small open reading frames.




Academic and Professional Experiences Member, American Society for Mass Spectrometry
Editorial board member,Molecular & Cellular Proteomics




Research Interests
Funcitonal Peptides
Chemical Biology
Proteomics and Mass Spectrometry



Achievements

Representative Publications
Bao X#, Zhao Q#, Yang T, Fung YME, Li XD*. A chemical probe for lysine malonylation. Angewandte Chemie - International Edition. 2013;52(18):4883-6.
Zhao Q, Ding Y, Deng Z, Lee OY, Gao P, Chen P, Rose RJ, Zhao H, Zhang Z, Tao XP, Heck AJR, Kao R, Yang D*. Natural products triptolide, celastrol, and withaferin A inhibit the chaperone activity of peroxiredoxin I. Chemical Science. 2015;6(7):4124-30.
Zhao Q#, Ouyang X#, Wan X, Gajiwala KS, Kath JC, Jones LH, Burlingame AL, Taunton J*. Broad-spectrum kinase profiling in live cells with lysine-targeted sulfonyl fluoride probes. Journal of the American Chemical Society. 2017;139(2):680-5.
Xiang L, Wei J, Tian XY, Wang B, Chan W, Li S, Tang Z, Zhang H, Cheang WS, Zhao Q, Zhao H, Yang Z, Hong Y, Huang Y, Cai Z*. Comprehensive Analysis of Acylcarnitine Species in db/db Mouse Using a Novel Method of High-Resolution Parallel Reaction Monitoring Reveals Widespread Metabolic Dysfunction Induced by Diabetes. Analytical Chemistry. 2017;89(19):10368-75.
Forester CM#, Zhao Q#, Phillips NJ, Urisman A, Chalkley RJ, Oses-Prieto JA, Zhang L, Ruggero D*, Burlingame AL*. Revealing nascent proteomics in signaling pathways and cell differentiation. Proceedings of the National Academy of Sciences U S A. 2018;115(10):2353-8
Terenzio M, Koley S, Samra N, Rishal I, Zhao Q, Sahoo PK, Urisman A, Marvaldi L, Oses-Prieto JA, Forester C, Gomes C, Kalinski AL, Di Pizio A, Doron-Mandel E, Perry RBT, Koppel I, Twiss JL, Burlingame AL, Fainzilber M*. Locally translated mTOR controls axonal local translation in nerve injury. Science. 2018;359(6382):1416-21.
Shao X, Ji F, Wang Y, Zhu L, Zhang Z, Du X, Chung ACK, Hong Y, Zhao Q*, Cai Z*, Integrative Chemical Proteomics-Metabolomics Approach Reveals Acaca/Acacb as Direct Molecular Targets of PFOA. Analytical Chemistry. 2018;90(18):11092-8.
Sze YH, Zhao Q, Cheung JKW, Li KK, Tse DYY, To CH, Lam TC*. High-pH reversed-phase fractionated neural retina proteome of normal growing C57BL/6 mouse. Scientific Data. 2021;8(27)
Leung HW, Leung ON, Lau EYT, Chung PS, Mok HK, Lei ML, Leung WH, Tong M, Keng V, Ma C, Zhao Q, Ng IOL, Ma S*, Lee KW*. EPHB2 activates β-catenin to enhance cancer stem cell properties and drive sorafenib resistance in hepatocellular carcinoma. Cancer Research. 2021;81(12):3229-40
Wang H#, Wang Y#, Yang J#, Zhao Q#, Tang N, Chen C, Li H, Cheng C, Xie M, Yang Y, Xie Z*. Tissue- and stage-specific landscape of the mouse translatome. Nucleic Acids Research. 2021;49(11):6165-80.