Prof. Wong Man-sau Assoc. Dean(AST), DoRCMI & Professor

Location Y806
Phone +852 3400 8665
mail man-sau.wong@polyu.edu.hk

Open Platform for University Scholars
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Education and Academic Qualifications Doctor of Philosophy, The University of Chicago
Bachelor of Science in Food Science, University of Illinois




Research Overview The primary focus of our laboratory is to study the use of dietary factors (nutrients and phytochemicals) and Chinese medicinal herbs (its bioactive fractions and ingredients) for improving bone health and prevention of age-related diseases as well as to delineate the mechanisms involved in mediating their protective effects.




Academic and Professional Experiences 2021-2024 Member, Committee on Reduction of Salt and Sugar in Food, Food and Health Bureau, HKSAR (15 March 2021 to March 14, 2024)
2019-2023 Member, Higher Education Review Board (HERB), Institute of Food Technologists (1 September 2019 to 31 August 2023)
2019-2021 Member, Advisory Council on Food and Environmental Hygiene, Food and Health Bureau, HKSAR (1 April 2019 to 31 March 2021)
2017-2023 Member, Chinese Medicine Industry Management Group, Chinese Medicine Council of Hong Kong, HKSAR
2015-2021 Council Member, Council on Human Reproductive Technology, HKSAR. (1 April 2015 to 31 March 2021)
2016-present Member, Steering Committee for "FOOD-CO" Intermediary Services for Building Capacity in Food Support Service, St. James' Settlement
2015-present. Chairperson, Expert Group on Maternal and Child Nutrition, Hong Kong Nutrition Association
2014-present Academic Advisor, The Hong Kong Nutrition Association Ltd.
2013-2023 Certified Food Scientist, Institute of Food Technologist
2008-present Council Member, Modernized Chinese Medicine International Association limited
2005- present Advisor, The Hong Kong Health Food Association
2017-2020 Visiting Professor, Shanghai University of Traditional Chinese Medicine, PRC
2016-2019 Adjunct Professor, Department of Nutritional Sciences, Purdue University, Indiana, USA
2016-2020 Executive Council Member, First Board of Specialty Committee of Osteoporosis of World Federation of Chinese Medicine Societies
2012-2017 Expert Member, "Chinese medicine new drug discovery and modernization professional platform
111计划"）暨南大学姚新生院士主持的 "中药创新药物发现与中药现代化创新引智基地"（B13038）专家成员
2008-2014 Member, Working Group on Diet and Physical Activity, A Strategic Framework for Prevention and Control of Non-Communicable Diseases, Department of Health, HKSAR"
2008-2014 Study Group Member, Study group on Childhood Nutrition (0-5), Subgroup 4, Department of Health, HKSAR
2010-2016 Member, Expert Committee on Food Safety, Food and Health Bureau, HKSAR
2006 summer Visiting Associate Professor, UIC/NOH Center for Botanical Dietary Supplement Research, College of Pharmacy, University of Illinois at Chicago
2004-2009 Adjunct Professor, Shenyang Pharmaceutical University
Associate Editor Journal of Ginseng Research since 2015
Editorial Board MemberAmerican Journal of Chinese Medicine, since 2006
Editorial Board MemberJournal of Traditional and Complementary Medicine, since 2011
Editorial Board Member Longhua Chinese Medicine, Sept 2018-Sept 2020




Research Interests
Bone and Mineral Metabolism
Diet and Diseases
Osteoporosis
Phytoestrogens
Phytochemicals
Traditional Chinese Medicine
Functional Food



Achievements

Awards
2017 Champion, Most Favorable PolyU Research News of 2016 "Most Favorite PolyU Research News of 2016" Facebook Campaign "Breastfeeding Research Discovers inadequate Calcium, Iron and Iodine Intakes of Hong Kong Lactating Women"
2016 Champion, Most Favorable PolyU Research News of 2015 "Most Favorite PolyU Research News of 2015" Facebook Campaign "Establishment of Hong Kong's First Breast Milk Nutrient Database"
2016 Faculty Service Award, Faculty of Applied Science and Textile, PolyU
2015 ABCT Star Award
2014 ABCT Star Award
2014 Higher Education Outstanding Scientific Research Output Awards (Science and Technology) from the Ministry of Education 國家教育部2013年度高等學校科學研究優秀成果獎（科學技術） Second Class Prize in Scientific and Technological Progress Award (科技进步奖) with the award-winning project ""Modernization and Application of Traditional Chinese Medicine for Anti-osteoporosis, 抗骨質疏鬆傳統中藥現代化研究及其應用
2012 Shenzhen Virtual University Park National Technology Project Pioneer Award, Shenzhen Technology and Innovation Committee "Study of the pharmacokinetics and pharmacodynamics of the use of Sambucus Willimaii Hance for treatment of osteoporosis"
2011 Highest International Consultancy Award, Outstanding Professional Services Awards
2011 PolyU Technology and Consultancy Co. Ltd."Effects of Fructus Ligustri Lucidi (FLL) and Puerariae Radix (PR) on calcium metabolism and bone properties in ovariectomized rats"
2006 Shandong Higher education Excellent Research Award Natural Science Award Third Prize "山东高等学校优秀科研成果奖自然科学类三等奖
Study of the molecular mechanism of phytoestrogens"




Patents
Wang AYY,Wong MSand Lo SCL Method for detecting immune responses. US patent application No. 10/756,768, filed on 14/1/2004
Wong MS, Yao XS, Xiao HH Dai Yi. The active fraction of Sambucus Williamsii Hance that reduce the risk of menopause related disease and its application
Application of oleanoic acid and urosolic acid as bioactive drug formulation for regulation of vitamin D metabolic enzymes"黄文秀, 董晓莉, 曹思思, 王奕 齐墩果酸和熊果酸在制备调节维生素D3代谢酶活性的药物中的应用 中国专利，申请号：2.0, filed on 02/11/2017
Wong M.S., Yao, X. S., Qiu, Z., Dong X & Dai, Y., 19 Nov 2019, IPC No. A23L33/10, Patent No. ZL2.5, 24 Feb 2016 (黄文秀，姚新生，邱佐成, 董晓莉，戴毅。异戊烯基二氢黄酮类化合物在防治骨疾病领域的应用)




Representative Publications
LP Zhou, CCW Poon, KY Wong, SS Cao, WX YU, XL Dong, WYW Lee, Y Zhang, MS Wong 2020 Prenylflavonoid Icariin Induces Estrogen Response Element–Independent Estrogenic Responses in a Tissue-Selective Manner J Endocrine Society 4 (2): 1-17 doi: 10.1210/jendso/bvz025
VWC Wong, YF Ng, SM Chan, YX Su, KWH Kwok, LHM Chan, CL Cheung, HW Lee, WY Pak, , SY Li, MS Wong 2019 Positive relationship between consumption of specific fish type and omega-3 polyunsaturated fatty acids in milk of Hong Kong lactating mothers Brit J Nutr. 121(12):1-3
Zeng J, Yu W, Dong X, Zhao S, Wang Z, Liu Y, Wong MS, Wang Y. 2019 A nanoencapsulation suspension biomimetic of milk structure for enhanced maternal and fetal absorptions of DHA to improve early brain development. Nanomedicine. 15(1):119-128. doi: 10.1016/j.nano.2018.09.006.
QG Gao, LP Zhou, VHY Lee, HY Chan, CWY Man, MS Wong 2019 Ginsenoside Rg1 activates ligand-independent estrogenic effects via rapid estrogen receptor (ER) signaling pathway J Ginseng Res 43(4):527-538. https://doi.org/10.1016/j.jgr.2018.03.004
Cao S, Wastney ME, Lachcik PJ, Xiao HH, Weaver CM, MS Wong 2018 Both oleanolic acid and a mixture of oleanolic and ursolic acids mimic the effects of Fructus ligustri lucidi on bone properties and circulating 1,25-dihydroxycholecalciferol in ovariectomized rats. J Nutr. 2018;148:1895–1902.doi: 10.1.1093/jn/nxy242
Xiao HH, Sham TT, Chan CO, Chen X, Mok DKW, Yao XS and MS Wong 2018 A metabolomics study on the bone protective effects of a lignan-rich fraction from Sambucus Williamsii Ramulus in aged rats Pharmacol. 9:932. doi: 10.3389/fphar.2018.00932.
LP Zhou, KY Wong, HT Yeung, XL Dong, GW Gong, HH Xiao, KWK Tsim, MS Wong 2018 Bone protective effects of Danggui Buxue Tang alone and in combination with tamoxifen or raloxifene in vivo and in vitro. Pharmacol. 9:779. doi: 10.3389/fphar.2018.00779
MX Ho, CW Poon KC Wong, ZC Qiu and MS Wong 2018 Icariin, but Not Genistein, Exerts Osteogenic and Anti-apoptotic Effects in Osteoblastic Cells by Selective Activation of Non-genomic ERα Signaling. Pharmacol 11;9:474. doi: 10.3389/fphar.2018.00474
Cao S, Dong XL, Ho MX, Yu WX, Wong KC, Yao XS, Wong MS. 2018 Oleanolic Acid Exerts Osteoprotective Effects and Modulates Vitamin D Metabolism Nutrients. 10(2). pii: E247
Y Zhang, LP Zhou, XL Li, YJ Zhao, MX Ho, ZC Qiu, DF Zhao, KW Mok, Q Shi, YJ Wang, MS Wong 2018 8-Prenylgenistein, a prenylated genistein derivative, exerted tissue selective osteoprotective effects in ovariectomized mice. Oncotarget 9(36):24221-24236.




Book Chapters
MS Wong, Y Zhang Flavonoids of Herba Epimedii and bone metabolism in experimental ovarian deficiency. In: Victor R. Preedy, eds. Handbook of Nutrition and Diet in Menopause. New York, NY: Springer Science+ Business Med; 2013"
HH Xiao, XS Yao and MS Wong. A lignan-rich bioactive fraction of Sambucus williamsii Hance exerts oestrogen-like bone protective effects in aged ovariectomized rats and osteoblastic cells. In Connie M. Weaver, Robin M. Daly, Heike A. Bischoff-Ferrari eds. Nutritional Influences on Bone Health. 9th International Symposium. Springer International Publishing AG, Cham, 2016.
SS Cao, XL Dong, Y Zhang and MS Wong Bone Protective Chinese Herbs: The Story of Fructus Ligustri Lucidi . In Connie M. Weaver, Robin M. Daly, Heike A. Bischoff-Ferrari Man-Sau Wong eds. Nutritional Influences on Bone Health. 10th International Symposium. Springer International Publishing AG, Cham, 2018.
MS Wong, CCW Poon, LP Zhou, HH Xiao. Natural products as potential bone therapies. In: Paula H Stern, eds. Handbook of Experimental Pharmacology. Springer Nature Switzerland AG, 2019"