Prof. Zhao Yanxiang Professor

Location Y835
Phone +852 3400 8706
mail yanxiang.zhao@polyu.edu.hk

Open Platform for University Scholars
ORCID ID
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Education and Academic Qualifications Doctor of Philosophy, The Rockefeller University
Master of Arts, State University of New York
Bachelor of Science, Peking University




Research Overview Our lab is interested in understanding the functional mechanism of important cellular signaling proteins, in particular the protein complexes that regulate cellular homeostasis and development in response to environmental stimuli.




Research Interests
Autophagy
Cell Metabolism
Structure-based Development of Functional Molecules with Therapeutic Potential



Achievements

Representative Publications
Deng Z, Lim J, Wang Q, Purtell K, Wu S, Wold MS, Carrasco GMP, Tan H, Manfredi G, Zhao Y, Peng J, Hu B, Chen S, Yue Z*. "ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/Nrf2 anti-oxidative stress pathway" Autophagy (2019) Jul 30:1-15. doi: 10.1080/15548627.2019.1644076.
Wu S, He Y, Qiu X, Yang W, Liu W, Li X, Li Y, Shen H-M, Wang R, Yue Z, Zhao Y*. "Targeting the potent Beclin 1-UVRAG coiled coil interaction with designed peptides enhances autophagy and endolysosomal trafficking" Natl. Acad. Sci. U.S.A. (2018); 115(25): E5669-E5678.
Pan X, He Y, Lei J, Huang X and Zhao Y*. "Crystallographic snapshots of Class A β-lactamase catalysis reveal structural changes that facilitate β-lactam hydrolysis" Biol. Chem. (2017); 292(10): 4022-4033.
Lim JY, Lachenmayer ML, Wu S, Liu W, Kundu M, Wang R, Komatsu M, Oh YJ, Zhao Y, and Yue Z. "Proteotoxic Stress Induces Phosphorylation of p62/SQSTM1 by ULK1 to Regulate Selective Autophagic Clearance of Protein Aggregates" PLOS Genetics. (2015) 11(2): e1004987
Jehi SE, Li X, Sandhu RS, Ye F, Benmerzouga I, Zhang M, Zhao Y*, Bibo Li*. "Suppression of subtelomeric VSG switching by Trypanosoma brucei TRF requires its TTAGGG repeat-binding activity". Nucleic Acids Res. (2014) 42(20):12899-12911 (*: co-corresponding authors)
McKnight NC, Zhong Y, Gong S, Phillips GR, Dou Z, Zhao Y, Heintz N, Zong W-X, Yue Z. "Beclin 1 Is Required for Neuron Viability and Regulates Endosome Pathways via the UVRAG-VPS34 Complex." PLOS Genetics. (2014) 10(10): e1004626.
Li X, He L, Zhang M, Yue Z, Zhao Y*. "The BECN1 coiled coil domain: An "imperfect" homodimer interface that facilitates ATG14 and UVRAG binding." Autophagy (2012); 8(8): 1258 – 1260.
Li X, He L, Che KH, Funderburk S, Pan L, Pan N, Zhang M, Yue Z, Zhao Y*. "Imperfect and metastable dimer interface of Beclin 1 coiled coil domain distinctively regulates its association with Atg14L and UVRAG" Nature Communications (2012); 3: 662.
Wong WT, Chan KC, So PK, Yap HK, Chung WH, Leung YC, Wong KY, Zhao Y*. "Increased structural flexibility at the active site of a fluorophore-conjugated β-lactamase distinctively impacts its binding toward diverse cephalosporin antibiotics." J Biol Chem. (2011); 286(36): 31771 – 31780.
Yu C, Feng W, Wei Z, Miyanoiri Y, Wen W, Zhao Y, Zhang M. "Myosin VI undergoes cargo-mediated dimerization." Cell (2009); 138: 537 – 548.