Prof. Yao Zhongping Professor

Location Y832
Phone +852 3400 8792
mail zhongping.yao@polyu.edu.hk

Open Platform for University Scholars
ORCID ID
SCOPUS ID









Education and Academic Qualifications Doctor of Philosophy, Hong Kong University of Science and Technology
Master of Science, Fudan University
Bachelor of Science, Fudan University




Research Overview We are an interdisciplinary team in mass spectrometry, analytical chemistry, chemical biology and -omics. We develop and apply mass spectrometry-based approaches to address fundamental and applied problems in chemistry, biology, medicine, food science, information science, etc.




Academic and Professional Experiences Panel Member for the Physical Sciences Subject (Joint Research Schemes), Hong Kong Research Grants Council, 2019 – present
Assessment Panel Member for the Biology and Medicine Subject (Competitive Research Funding Schemes for the Local Self-financing Degree Sector), Hong Kong Research Grants Council, 2019 – present
President, The Hong Kong Society of Mass Spectrometry, 2018 – present
International Committee Member, Asia Oceania Mass Spectrometry Society, 2017 – present
Member of Organic Analysis Committee, The Chinese Chemical Society, 2016 – present
Member, Asian CORE Program in Chemical Biology, 2011 – present
Series Editor for the book series on New Developments in Mass Spectrometry, The Royal Society of Chemistry, 2018 – 2022
Editorial Board Member, Rapid Communications in Mass Spectrometry, 2013 – present (2013 – 2020, associate member; 2020 – present, full member)
Editorial Board Member, Natural Products Chemistry & Research, 2012 – present
Editorial Board Member, Chemical Biology Letters, 2015 – present




Research Interests
Mass Spectrometry
Molecular Assembly and Recognition
Protein Structures, Dynamics and Interactions
Food Safety
Data Storage
Disease Biomarkers and Mechanisms of Biological Processes



Achievements

Awards
Most Valued Project Award (merit), The Hong Kong Polytechnic University, 2019
“Changbaishan Scholar” Chair Professor, Jilin Province, China, 2015-2018
Visiting Associate Professor, Kyoto University, 2013
RCUK Academic Fellowship, Research Council UK, 2006-2008.
First Class Prize (First Accomplisher), CAIA Award, The China Association for Instrumental Analysis (CAIA), 1995




Patents
Zhongping YAO, Cheuk Chi Albert NG, Francis Chung Ming Lau, Wai Man TAM, “Data Storage Using Peptides”, US Provisional Patent (Application No. 62/657,026, filed on 13 April 2018); PCT Patent (Application No. PCT/CN2018/119349, filed on 6 December 2018); US Non-Provisional Patent (Application No. 16/224,957, filed on 19 December 2018); US Continuation-in-part Patent (Application No. 16/949,04, filed on 12 October 2020).
Zhongping YAO, Cheuk Chi Albert NG, Tsz Tsun NG, Suying LI, “Improved Edible Oil Analysis System and Method”, PCT Patent (Application No. PCT/IB2017/053821, filed on 27 June 2017); US Patent (Application No. 15/628,043, filed on 27 June 2017, announcement date: 08 December 2020, announcement No. US10859552B2); Taiwan Patent (Application No. 106121410, filed on 27 June 2017, announcement date: 01 January 2021, announcement No. TWI714784B); EU Patent (Application No.17181140.9-1408, filed on13 July 2017); China Patent (Application No. 2.1, filed on 19 July 2017).
Zhongping YAO, Tsz Tsun NG, Pui-Kin SO, “A Method for Authentication of Edible Oils (鉴别食用油的方法)”, China Patent (Application No.: 2.2, filed on 13 October 2014, Patent No.: ZL2.2, announcement date: 02 July 2019, announcement No. CN 105486744 B).
Zhongping YAO, Haixing WANG, “An Electrospray Ionization Device for Direct Analysis of Solid Samples (一種直接分析固體樣品的電噴霧電離裝置)”, China Patent (filed on 24^th March 2014, Patent No.: 2.3, announcement No. CN203674161U).
Zhongping YAO, Bin HU, “Electrospray Ionization Device (電噴霧電離裝置)”, China Patent (filed on 27 January 2014, Patent No. 2.9, announcement date: 08 February 2018, announcement No. CN104282524B).




Representative Publications
Ng, C. C. A.; Tam, W. M.; Yin, H. D.; Wu, Q.; So, P. K.; Wong, M. Y. M.; Lau, F. C. M.;* Yao, Z. P.* Data Storage Using Peptide Sequences, Nat. Commun. 2021, 12, 4242. DOI: 10.1038/s41467-021-24496-9.
Huang, Y.;^# Yin, H. D.;^# Li, B. Y.;^# Wu, Q.; Liu, Y.; Poljal, K.; Tang, X.; Wang, M.; Wu, Z. X.; Miller, E. A.; Jiang, L. W.; Yao, Z. P.;* Guo, Y. S.;* An in vitro Vesicle Formation Assay to Uncover Novel Factors that Mediate Vesicular Trafficking and Cargo Clients of a Specific Cellular Factor, Proc. Natl. Acad. Sci. USA 2021, 118, e2101287118. (^#co-first author)
Huang, L. W.; So, P. K.; Chen, Y. W.; Leung, Y. C.; Yao, Z. P.* Interdomain Flexibility and Interfacial Integrity of β-Lactamase Inhibitory Protein (BLIP) Modulate Its Binding to Class A β-Lactamases, J. Biol. Chem. 2021, 297, 100980. (Editors’ Pick)
Li, S. Y.; Ng, T. T.; Yao, Z. P.* Quantitative Analysis of Blended Oils by Matrix-assisted Laser Desorption/Ionization Mass Spectrometry and Partial Least Squares Regression, Food Chem. 2021, 334, 127601.
Huang, L. W.; So, P. K.; Chen, Y. W.; Leung, Y. C.; Yao, Z. P.* Conformational Dynamics of Helix 10 Region as An Allosteric Site in Class A β-Lactamase Inhibitory Binding, J. Am. Chem. Soc. 2020, 124, 13756-13767.
Wu, Q.; Wang, J. Y.; Han, D. Q.; Yao, Z. P.* Recent Advances in Differentiation of Isomers by Ion Mobility Mass Spectrometry, Trends Anal. Chem. 2020, 124, 115801. (Invited review)
Han, D. Q.; Yao, Z. P.* Chiral Mass Spectrometry: An Overview, Trends Anal. Chem. 2020, 123, 115763. (Invited review)
Huang, L. W.; So, P. K.; Yao, Z. P.* Protein Dynamics Revealed by Hydrogen Deuterium Exchange Mass Spectrometry: Correlation between Experiments and Simulation, Rapid Commun. Mass Spectrom. 2019, 33(S3), 83-89. (Invited Perspective article; Top Downloaded Paper 2018-2019 of the journal)
Yu. X. Y.; Chau, M. C.; Tang, W. K.; Siu, C. K.;* Yao, Z. P.* Self-assembled Binuclear Cu(II)-Histidine Complex for Absolute Configuration and Enantiomeric Excess Determination of Naproxen by Tandem Mass Spectrometry, Anal. Chem. 2018, 90, 4089-4097.
Hu, B.;^# So, P. K.;^# Yang, Y. Y.;* Deng, J. W.; Choi, Y. C.; Luan, T. G.; Yao, Z. P.* Surface-modified Wooden-tip Electrospray Ionization Mass Spectrometry for Enhanced Detection of Analytes in Complex Samples, Anal. Chem. 2018, 90, 1759-1766. (^#co-first author)




Book Chapters
Liu, R.; So. P. K.; Wong, M. Y. M.; Hu, B.; Yao, Z. P. In Vivo Detection of Secondary Metabolites, In Reference Module in Chemistry, Molecular Sciences and Chemical Engineering, Elsevier Press, 2016, chapter 11575. (DOI: 10.1016/B978-0-12-409547-2.11575-6).
So. P. K.; Yao, Z. P. Expanding Role of Mass Spectrometry for Characterization of Proteins, In Peptides: Chemistry, Biology and Pharmaceutical Sciences, Wang, R. and Wang, K. R. Ed.; Chemical Industry Press, 2011, pp97-101. (ISBN: 978-7-122-10788-6)
Yao, Z. P.; Tito, P.; Robinson C. V. Site Specific Hydrogen Exchange of Proteins: Insights into the Structures of Amyloidogenic Intermediates, In Biological Mass Spectrometry (Methods in Enzymology series, Volume 402); Burlingame, A. L., Ed.; Elsevier Press, 2005, chapter 12, pp389-402. (ISBN: 978-0-12-182807-3)