Prof. Wong Wing-tak Deputy President and Provost & Chair Professor of Chemical Technology

Location M1710
Phone +852 3400 8789
mail w.t.wong@polyu.edu.hk

Open Platform for University Scholars
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Education and Academic Qualifications Doctor of Philosophy, University of Cambridge
Doctor of Science, University of Cambridge
Master of Philosophy, The University of Hong Kong
Bachelor of Science, The University of Hong Kong




Professional Qualifications Chartered Scientist
Chartered Chemist
Fellow of Royal Society of Chemistry




Research Overview My research areas mainly include the development of molecular probes for biological imaging and X-ray crystallography. A wide range of lanthanide-based materials have been developed for optical and magnetic resonance imaging applications while their fundamental properties are thoroughly investigated for performance optimization.




Research Interests
Lanthanide Complexes for MR Imaging
Molecular Probes for Chemical Imaging
Nanostructures for Ion Sensing
X-Ray Crystallography



Achievements

Awards
2000 Doctor of Science, University of Cambridge, UK
2001 Outstanding Young Researcher Award, HKU
2002 Croucher Senior Research Fellowship, The Croucher Foundation
2003 Outstanding Research Student Supervisor Award, HKU
2008 Outstanding Researcher Award, HKU
2012 Outstanding Achievement Award in Scientific Research for Institution of Higher Education of China
2015 Gold Award, 43rdInternational Exhibition of Inventions of Geneva
2020 Ministry of Education Higher Education Outstanding ScientificResearch Output Award, Second-class Award in Natural Science






Patents
Wong WT, Chan WY"Optimized relaxivity and specificity hepatobiliary MRI contrast agent". U.S. Patent 7,767,196. 3 Aug 2010.
Yung KF,Wong WT, Kwong TL"Methods and catalysts for green biodiesel production from unrefined low grade feedstock". U.S. Patent 9,694,350. 4 Jul 2017.
Yung KF,Wong WT, Kwong TL"Methods and catalysts for green biodiesel production from unrefined low grade feedstock". European Patent 3274298. 9 Oct 2019.
Yung KF,Wong WT, Kwong TL, Lau PC"Catalyst and method for biodiesel production from unrefined low-grade oil and crude aqueous alcohols". U.S. Patent 2A1.




Representative Publications
Lui KH, Li S, Lo WS, Gu Y, Wong WT. In vivo photoacoustic imaging for monitoring treatment outcome of corneal neovascularization with metformin eye drops Biomedical Optics Express. 2021; 12(6): 3597-3606.
Li S, Lui KH, Li X, Fang X, Lo WS, Gu Y, Wong WT. pH-triggered poly(ethylene glycol)-poly(lactic acid)/glycolic acid)/croconaine nanoparticles-assisted multiplexed photoacoustic imaging and enhanced photothermal cancer therapy ACS Applied Bio Material 2021; 4: 4152-4164.
Fang X, Wu X, Li Z, Jiang L, Lo W, Chen G, Gu Y, Wong WT. Biomimetic anti-PD-1 peptide-loaded 2D FePSe₃ nanosheets for efficient photothermal and enhanced immune therapy with multimodal MR/PA/thermal imaging. Advanced Science, 2020; 8(2): 2003041.
Lai WF, Wong WT, Rogach AL. Development of copper nanoclusters for in vitro and in vivo theranostic applications Advanced Materials. 2020; 32: 1906872-1906893.
Jiang L, LungHL , Huang T, Lan R, Zha S, Chan LS, Thor W, Tsoi TH, Chau HF Borestr?m C, Cobb SL, Tsao SW, Bian ZX, Law GL , Wong WT, Tai WCS, Chau WY, Du Y, Tang LHX, Chiang AKS, Middeldorp JM, Lo KW, Mak NK, Long NJ, Wong KL. Reactivation of epstein-barr virus by a dual-responsive fluorescent EBNA1-targeting agent with Zn²⁺-chelating function.Proceedings of the National Academy of Science. 2019;116(52): 26614-24.
Tsang MK, Wong YT, Tsoi TH, Wong WT, Hao J. Upconversion luminescence sandwich assay for detection of influenza H7 subtype. Advanced Healthcare Materials. 2019; 8(18): 1900575-83.
Dai L, Lo WS, Gu Y, Xiong Q,Wong KL, Kwok WM , Wong WT, Law GL. Breaking the 1,2-HOPO barrier with a cyclen backbone for more efficient sensitization of Eu(III) luminescence and unprecedented two-photon excitation properties. Chemical Science 2019; 10(17): 4550-9.
Zhu L., Ma W,Zhang M,Lee MML, Wong WY, Chan BD, Yang Q, Wong WT, Tai WCS, Lee CS. Scalable synthesis enabling multilevel bio-evaluations of natural products for discovery of lead compounds. Nature Communications 2018; 9: 1283.
Yeung CT, Yim KH, Wong HY, Pal R, Lo WS, Yan SC, Wong MYM, Yufit D, Smiles DE, McCormick LJ, Teat SJ, Shuh DK, Wong WT, Law GL. Chiral transcription in self-assembled tetrahedral Eu4L6 chiral cages displaying sizable circularly polarized luminescence. Nature Communications 2017; 8: 1128.
Jiang LJ, LanRF, Huang T, Chan CF, Li HG, Lear S, Zong JY, Wong WY, Lee MML, Chan BD, Chan WL, Lo WS, Mak NK, Lung ML, Lung HL, Tsao SW, Taylor GS, Bian ZX, Tai WCS, Law GL, Wong WT, Cobb SL, Wong KL. EBNA1-targeted probe for the imaging and growth inhibition of tumours associated with the Epstein-Barr virus.Nature Biomedical Engineering. 2017; 1(4): 0042.




Book Chapters
Long N. J.Wong WT. "The Chemistry of Molecular Imaging". Indianapolis (IN): Wiley; 2015 (Editor)
Wong WTJin J., "Upconversion Nanoparticles for Bioimaging Application
Gadolinium Complexes as MRI Contrast Agents for Diagonsis
Compounds Containing Bonds between Fe and Other Transition Metals, Group 11, 12 elements
Heterometallic Ru/Os Containing Compounds",Comprehensive Organometallic Chemistry III, Edited by R.H. Crabtree and D.M.P. Mingos, 2006 Elsevier.