Dr Wong Tsun-ting , Clarence Research Assistant Professor

Location Y824-08
Phone +852 3400 8674
mail clarence-tt.wong@polyu.edu.hk

Open Platform for University Scholars
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Education and Academic Qualifications Doctor of Philosophy, Nanyang Technology University
Bachelor of Science , The Chinese University of Hong Kong




Research Overview My research group focuses on using state-of-the-art peptide and protein chemistries to manipulate biological systems, including (1) development of multifunctional antibodies for immunotherapy; (2) chemical manipulation of cell behaviour for cell-based therapeutic development; and (3) chemical modification of functional proteins for diseases detection and treatment




Research Interests
Chemical Biology
Peptide and Protein
Immunology
Medicinal and Pharmaceutical Chemistry
Drug Discovery
Cancer Therapeutics



Achievements

Patents
Compounds, compositions and methods for the preparation of peptide/protein conjugates. Li, X., Tung, C. L.,Wong, C. T. T.US9752137B2, CN104877982B




Representative Publications
Chu, J. C. H., Chin, M. L.,Wong, C. T. T.*, Hui, M.*, Lo, P. C.*, Ng, D. K. P.* One-Pot Synthesis of a Cyclic Antimicrobial Peptide-Conjugated Phthalocyanine for Synergistic Chemo-Photodynamic Killing of Multidrug-Resistant Bacteria.Adv. Therap.2020, 2000204.
Chu, J. C. H., Yang, C., Fong, W. P., Wong, C. T. T.*, Ng, D. K. P.* Facile One-Pot Synthesis of Cyclic Peptide-Conjugated Photosensitiser For Targeted Photodynamic Therapy. Chem. Commun. 2020, 55, 11941.
Wong, C. T. T.*, Chu J. C. H., Ha, S. Y. Y., Wong, R. C. H., Dai, G., Kwong, T. T., Wong, C. H., Ng, D. K. P.* Phthalaldehyde-Amine Capture Reaction For Bioconjugation and Immobilization of Phthalocyanines.Org. Lett.2020, 22, 7098.
Zhang, Y., Zhang, Q.,Wong, C. T. T., Li, X. Chemoselective Peptide Cyclization and Biocyclization Directly on Unprotected Peptides.J. Am. Chem. Soc.2019, 141.12274.
Lee, C. L., Liu, H.Wong, C. T. T., Chow, H. Y. and Li, X. Enabling N-to-C Ser/Thr Ligation for Convergent Protein Synthesis via Combining Chemical Ligation Approaches.J. Am. Chem. Soc.2016, 138, 10477-10484.
Tung, C. L.,Wong, C. T. T., Fung, E. Y. M. and Li, X. Traceless and Chemoselective Amine Bioconjugation via Phthalimidine Formation in Native Protein Modification.Org. Lett.2016, 18, 2600-2603.
Wong, C. T. T., Lam, H. Y., Song, T., Chen, G. and Li, X. Synthesis of Constrained Head-to- Tail Cyclic Tetrapeptides by Imine-Induced Ring-Closing/Contraction Strategy.Angew. Chem. Int. Ed.2013, 52, 10212-10215.
Lam, H. Y., Zhang, Y., Liu, H., Xu, J.,Wong, C. T. T.,Xu, C. and Li, X. Total Synthesis of Daptomycin by Cyclization via a Chemoselective Serine Ligation.J. Am. Chem. Soc.2013, 135, 6272-6279.
Wong. C. T. T., Rowlands, D. K., Wong, C. H., Lo, T. W. C., Nguyen, G. K. T., Li, H, Y., Tam, J. P. Orally Active Peptidic Bradykinin B1 Receptor Antagonists Engineered from a Cyclotide Scaffold for Inflammatory Pain Treatment.Angew. Chem. Int. Ed.2012, 51, 5620