Dr Wong Man-kin Assoc. Head(ABCT) & Assoc. Professor

Location Y852
Phone +852 3400 8701
mail mankin.wong@polyu.edu.hk

ORCID ID
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Education and Academic Qualifications Doctor of Philosophy, The University of Hong Kong
Bachelor of Science, The University of Hong Kong




Research Overview Our research group uses Synthetic Chemistry as a core technology to address problems in Chemistry, Chemical Biology and Food Safety.




Research Interests
Catalysis
Bioconjugation
Molecular Imaging
Food Safety



Achievements

Awards
Asian Core Program Lectureship Awards: 2011 (Japan), 2014 (China), 2014 (Thailand), 2016 (Korea), and 2016 (Taiwan)




Patents
Method and Kit for Detecting Formaldehyde in Food based on Metal Catalysis Coupling Reaction.
Da-Peng Xiang,Man-Kin Wong, Ching Liu, Xiao-Qun Wei, Ka-Hing Wong, Kong-Fan Wong and Shi-Ping Shao
CN 104193672 A
Chiral Gold(III) Complexes Preparation and Applications.
Man-Kin Wongand Jian-Fang Cui
2.5
New Quinolizinium Dyes Preparation and Application on Photoredox Catalysis.
Man-Kin Wong, Jieren Deng and Chun Him Nathanael Lai
2.5




Representative Publications
Deng JR, Lai NCH, Kung KKY, Yang B, Chung SF, Leung ASL, Choi MC, Leung YC, Wong MK. N-Terminal selective modification of peptides and proteins using 2-ethynylbenzaldehydes. Communications Chemistry, 2020, 3(1), 67.
Deng JR, Chung SF, Leung, ASL, Yip WM, Yang B, Choi MC, Cui JF, Kung KKY, Zhang Z, Lo KW, Leung YC, Wong MK. Chemoselective and photocleavable cysteine modification of peptides and proteins using isoxazoliniums. Communications Chemistry. 2019; 2(1): 93.
Sit HY, Yang B, Kung KKY, Tam JS-L, Wong MK. Fluorescent Labelling of Glycans with FRET-Based Probes in a Gold(III)-Mediated Three-Component Coupling Reaction. ChemPlusChem. 2019; 84(11):173943.
Jiang JJ, Cui JF, Yang B, Ning Y, Lai NCH, Wong MK. Chiral Cyclometalated Oxazoline Gold(III) Complex-Catalyzed Asymmetric Carboalkoxylation of Alkynes. Organic Letters. 2019; 21(16): 6289-94.
Deng JR, Chan WC, Chun-Him Lai N, Yang B, Tsang CS, Chi-Bun Ko B, Lai-Fung Chan S, Wong MK. Photosensitizer-free visible light-mediated gold-catalysed cis-difunctionalization of silyl-substituted alkynes. Chemical Science. 2017;8(11):7537-44.
Cui JF, Ko HM, Shing KP, Deng JR, Lai NCH, Wong MK. C,O-Chelated BINOL/Gold(III) Complexes: Synthesis and Catalysis with Tunable Product Profiles. Angewandte Chemie - International Edition. 2017;56(11):3074-9.
Wong KF, Deng JR, Wei XQ, Shao SP, Xiang DP, Wong MK. Visual detection of formaldehyde by highly selective fluorophore labeling via gold(III) complex-mediated three-component coupling reaction. Organic and Biomolecular Chemistry. 2015;13(27):7408-11.
Kung KKY, Ko HM, Cui JF, Chong HC, Leung YC, Wong MK. Cyclometalated gold(III) complexes for chemoselective cysteine modification via ligand controlled C—S bond-forming reductive elimination. Chemical Communications. 2014;50(80):11899-902.
Kung KKY, Wong KF, Leung KC, Wong MK. N-terminal α-amino group modification of peptides by an oxime formation-exchange reaction sequence. Chemical Communications. 2013;49(61):6888-90.
Ko HM, Kung KKY, Cui JF, Wong MK. Bis-cyclometallated gold(III) complexes as efficient catalysts for synthesis of propargylamines and alkylated indoles. Chemical Communications. 2013;49(78):8869-71.




Book Chapters
Book Chapter Title: Asymmetric Epoxidation Catalyzed by Chiral Ketones.
Man Kin Wong, Yiu Chung Yip and Dan Yang
In the book "Asymmetric Catalysis from Chinese Perspective"
Springer, 2011
Editor: Prof. Shengming Ma