Dr Seto Sai-wang Assoc. DoRCMI & Assistant Professor

Location Y851
Phone +852 3400 8672
mail saiwang.seto@polyu.edu.hk

Open Platform for University Scholars
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Education and Academic Qualifications Doctor of Philosophy, The Chinese University of Hong Kong
Bachelor of Science, The University of Liverpool




Professional Qualifications British Pharmacological Society - Member
Royal Pharmacological Society - SRPharmS
NICM Health Research Institute, Western Sydney University - Adjunct Fellow





Research Overview Our group is interested in the discovery of novel therapeutic targets for complex and multi-factorial health problems.




Research Interests
Pharmacology
Bone-derived Proteins and Vascular Diseases
Chinese Herbal Medicine for Cerebrovascular Diseases



Achievements

Awards
Young Investigator Award (2008) - Institute of Cardiovascular Science and Medicine - 12th Annual Scientific Meeting, Hong Kong
Australian Government National Health and Medical Research Council (NHMRC) Training Fellowship (2011-2012)
National Heart Foundation (NHF) Postdoctoral Fellowship (2013-14)
National Heart Foundation (NHF) of Australia – Exchange and Collaboration Award (2013)
Cardiac Health Institute Research Fellowship (2015-2020)




Representative Publications
He L, Shi X,Seto SW, Chang D, Wang H, Zhang S, Chen W, Wang J (2019) Using 3D-UPLC-DAD and a new method-verification by adding mixture standard compounds to determine the fingerprint and eight active components of Naoluoxintong decoction.J Pharm Biomed Anal.169: 60-69.
Kazzem M, Sun YT, Low M, ^Seto SW, Chang D, Lee S, Suresh H, Khoo CS, Bensoussam A, Kiat H (2019) Chromatographic Analysis and Anti-oxidative Property of Naoxinqing Tablet, a Proprietary Preparation of Diospyros Kaki Leaves.Molecules.24(6) pii:E1101 (^: Corresponding author)
Wu S, Wang N, He Q, Chang G,Seto SW, Chang D, Liang H (2018) The Establishment of the Method of Cell Biochromatograpy and Analysis of the Active Ingredients from TongQiaoHuoXue Decoction Acting on the Neurocytes.Chem Pharm Bull (Tokyo). 66(10): 983-991
Yang G, Wang N,Seto SW, Chang D, & Liang H. (2018). Hydroxysafflor yellow a protects brain microvascular endothelial cells against oxygen glucose deprivation/reoxygenation injury: Involvement of inhibiting autophagy via class I PI3K/Akt/mTOR signaling pathway.Brain Research Bulletin.140: 243-257.
Seto SW, Chang D, Kiat H, Wang N, Bensoussan A (2018) Chinese Herbal Medicine as a Potential Treatment of Abdominal Aortic Aneurysm.Frontiers in Cardiovascular Medicine.doi: 10.3389/fcvm.2018.00033.
Li Z, Zhang J, Zou L, Lee SMY, Yang C,Seto SW, Leung GPH (2017) Pro-angiogenic effecets of ilexsaponin A on human umbilical vein endothelial cells in vitro and zebrafish in vivo.Phytomedicine36: 229-237
Seto SW, Chang D, Ko WM, Zhou X, Kiat H, Bensoussan A, Lee SM, Hoi MP, Steiner GZ, Liu J. (2017) Sailuotong Prevents Hydrogen Peroxide (H?O?)-Induced Injury in EA.hy926 Cells.Int J Mol Sci18(1) E95 (First and Corresponding author)
Krishna SM, ^Seto SW, Jose RJ, Li J, Morton SK, Biros E, Wang Y, Nsengiyumva V, Lindeman JH, Loots GG, Rush CM, Craig JM, Golledge J (2017) Wnt Signaling Pathway Inhibitor Sclerostin Inhibits Angiotensin II-Induced Aortic Aneurysm and Atherosclerosis.Arterioscler Thromb Vasc Biol.37(3): 553-566 (^: Co-first authorship)
Moran CS, ^Seto SW, Krishna S, Sharma S, Jose RJ, Biros E, Wang Y, Morton SK, Golledge J (2017) Parenteral administration of factor Xa/IIa inhibitors limits experimental aortic aneurysm and atherosclerosis.Scientific Reports7:43079. (^: Co-first authorship)
Krishna SM,Seto SW, Jose R, Li J, Moxon J, Clancy P, Crossman DJ, Norman P, Emeto TI, Golledge J (2017) High serum thrombospondin-1 concentration is associated with slower abdominal aortic aneurysm growth and deficiency of thrombospondin-1 promotes angiotensin II induced aortic aneurysm in mice.Clin Sci (Lond). 131(12):1261-1281.