Dr Chua Song-lin Assistant Professor

Location Y844
Phone +852 3400 8682
mail song-lin.chua@polyu.edu.hk

Open Platform for University Scholars
ORCID ID
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Education and Academic Qualifications Doctor of Philosophy, National University of Singapore
Bachelor of Science in Biomedical Sciences, Nanyang Technological University




Research Overview My research focuses include system biology approaches such as proteomics and transcriptomics; elucidate mechanisms of bacterial pathogenesis such as biofilm-host interactions and antimicrobial resistance; and developing novel therapeutics to eradicate infections.




Academic and Professional Experiences Member, American Society of Microbiology (ASM)




Research Interests
Proteomics to Study Biofilm's Antimicrobial Tolerance
Biofilm Dispersal & Pathoenesis
Development of Anti-biofilm Approaches
Medical Microbiology
Host-pathogen Interactions
Antimicrobial Development



Achievements

Patents
HFP09125 (2020), US Patent Pending
Lee Kong Chian Medicine Fellowship, 2016-2018, Nanyang Technological University, Singapore
[1] US patent pending, 63/150,716
[2] US patent pending, 63/091,449




Representative Publications
S. Y. Liu, M. M. Leung, J. K. Fang,S. L. Chua(2021). "Engineering a microbial 'trap and release' mechanism for microplastics removal".Chemical Engineering Journal. 404: 127079

S. Y. Chan, S. Y. Liu, Z. Seng,S. L. Chua(2020). "Biofilm matrix disrupts nematode motility and predatory behavior".ISME Journal. Doi:https://doi.org/10.1038/s41396-020-00779-9

N. Mok, S. Y. Chan, S. Y. Liu,S. L. Chua(2020). "Vanillin inhibits PqsR-mediated virulence in Pseudomonas aeruginosa".Food & Function.7(11), 6496-6508

M. Yu,S. L. Chua(2019). "Demolishing the great wall of biofilms in Gram‐negative bacteria: To disrupt or disperse?".Medicincal Research Reviews.40(3): 1103-1116

S. L. Chua, Y. Liu, Y. Li, H. J. Ting, G. S. Kohli, Z. Cai, P. Suwanchaikasem, K. K. K. Goh, S. P. Ng, T. Tolker-Nielsen, L. Yang and M. Givskov (2017). "Reduced intracellular c-di-GMP content increases expression of quorum sensing-regulated genes inPseudomonas aeruginosa".Front. Cell. Infect. Microbiol. Doi:https://doi.org/10.3389/fcimb.2017.00451

S. L. Chua, Y. Ding, Y. Liu, Z. Cai, J. Zhou, S. Swarup, D. I. Drautz-Moses, S. C. Schuster, S. Kjelleberg, M. Givskov, L. Yang. (2016) Reactive oxygen species drive evolution of pro-biofilm variants in pathogens by modulating cyclic-di-GMP levels.Open Biology6(11): 160162.

S. L. Chua, J. K. Yam, P. Hao, M. M. Salido, S. K. Sze, M. Givskov, T, Tolker-Nielsen, L. Yang. (2016) Selective proteome labelling and eradication of antibiotic-tolerant bacterial populations in pathogenic biofilms.Nature Commun7: 10750

S. Yu, T. Su, H. Wu, S. Liu, D. Wang, T. Zhao, Z. Jin, W. Du, M. J. Zhu,S. L. Chua, L. Yang, D. Zhu, L. Gu and L. Z. Ma (2015). "PslG, a self-produced glycosyl hydrolase, triggers biofilm disassembly by disrupting exopolysaccharide matrix."Cell Research25(12): 1352-1367.

S. L. Chua, L. D. Hultqvist, M. Yuan, M. Rybtke, T. E. Nielsen, M. Givskov, T. Tolker-Nielsen and L. Yang (2015). "In vitro and in vivo generation and characterization ofPseudomonas aeruginosabiofilm-dispersed cells via c-di-GMP manipulation."Nat Protoc10(8): 1165-118.

S. L. Chua, K. Sivakumar, M. Rybtke, M. Yuan, J. B. Andersen, T. E. Nielsen, M. Givskov, T. Tolker-Nielsen, B. Cao, S. Kjelleberg and L. Yang (2015). "C-di-GMP regulatesPseudomonas aeruginosastress response to tellurite during both planktonic and biofilm modes of growth."Sci Rep5: 10052.

S. L. Chua, Y. Liu, J. K. Yam, Y. Chen, R. M. Vejborg, B. G. Tan, S. Kjelleberg, T. Tolker-Nielsen, M. Givskov and L. Yang (2014). "Dispersed cells represent a distinct stage in the transition from bacterial biofilm to planktonic lifestyles."Nat Commun5: 4462.

S. L. Chua, S. Y. Tan, M. T. Rybtke, Y. Chen, S. A. Rice, S. Kjelleberg, T. Tolker-Nielsen, L. Yang and M. Givskov (2013). "Bis-(3'-5')-cyclic dimeric GMP regulates antimicrobial peptide resistance inPseudomonas aeruginosa."Antimicrob Agents Chemother57(5): 2066-2075.

S. Y. Tan,S. L. Chua, Y. Chen, S. A. Rice, S. Kjelleberg, T. E. Nielsen, L. Yang and M. Givskov (2013). "Identification of five structurally unrelated quorum-sensing inhibitors of Pseudomonas aeruginosa from a natural-derivative database."Antimicrob Agents Chemother57(11): 5629-5641.

Deng Y, Liu SY, Chua SL, Khoo BL. The effects of biofilms on tumor progression in a 3D cancer-biofilm microfluidic model. Biosensors and Bioelectronics. 2021;180:113113.





Book Chapters
S. L. Chua, L. Yang (2017). "Proteogenomics ofPseudomonas aeruginosain cystic fibrosis infections."MALDI‐TOF and Tandem MS for Clinical Microbiology.451-491
Rybtke,S. L. Chua, J. K. H. Yam, M. Givskov, L. Yang, T. Tolker-Nielsen (2017). "Gauging and visualizing c-di-GMP levels inPseudomonas aeruginosausing fluorescence-based biosensors".C-di-GMP Signaling.87-98.




Awards
Lee Kong Chian Medicine Fellowship, 2016-2018, Nanyang Technological University, Singapore