Dr Dong Xiaoli Research Assistant Professor

Location Y817
Phone +852 3400 8668
mail xiaoli.dong@polyu.edu.hk

Open Platform for University Scholars
ORCID ID
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Education and Academic Qualifications Doctor of Philosophy, The Hong Kong Polytechnic University
Master of Medicine, Qingdao University Medical College
Bachelor of Medicine, Jining Medical College




Research Overview My research interests include Pathogenic mechanism studies of age-related diseases including Parkinson's disease and osteoporosis, Novel therapy (Food-based therapies) development for treatment of neurodegenerative disease and bone disease and Functional food development for mental and bone health






Research Interests
Parkinson’s disease
Osteoporosis
Food-based therapies
Functional foods



Achievements

Patent
黄家兴，董晓莉，陆家谦，张兆滔。一种纳米硒水溶胶及其制备方法与应用。专利申请号：2.5
黄文秀，董晓莉，曹思思，王奕。齐敦果酸和熊果酸在制备调节维生素D₃代谢酶活性的药物中的应用。中国专利，已授权 专利号：ZL 2017 1 1061004.0
黄文秀，姚新生，邱佐成，董晓莉，戴毅。异戊烯基二氢黄酮类化合物在防治骨疾病领域的应用 中国专利，已授权 专利号：ZL 2016 1 0102211.5
李小花，董晓莉，赵清，张焕。三萜类化合物在制备治疗帕金森药物中的应用。中国专利，已授权 专利号：ZL 2015 1 0673284.5




Representative Publications
Liu X, Du ZR, Wang X, Luk KH, Chan CH, Cao X, Zhao Q, Zhao F, Wong WT, Wong KH*, Dong XL*. Colonic dopaminergic neurons changed reversely with those in the midbrain via gut microbiota-mediated autophagy in a chronic Parkinson's disease mice model. Frontiers in Aging Neuroscience, 2021, 13: 649627
Dong XL, Wang X, Liu F, Liu X, Du ZR, Li RW, Hu XC, Wong KH, Wong WT, Zhao Q, Tang QJ*. Polymannuronic acid prevents dopaminergic neuronal loss via brain-gut-microbiota axis in Parkinson's disease model. International Journal of Biological Macromolecules, 2020, 164: 994-1005
Dong XL, Yu WX, Li CM, He S, Zhou LP, Poon CW, Wong MS*. Danshen(Salvia miltiorrhiza) protects ovariectomized rats fed with high-saturated fat-sucrose diet from bone loss. Osteoporosis International, 2018, 29(1):223-235
Cao S, Dong XL, Ho MX, Yu WX, Wong KC, Yao XS, Wong MS*. Oleanolic acid exerts osteoprotective effects and modulates vitamin D metabolism. Nutrients, 2018, 10 (2): 247
Dong XL, Zhang JX, Zhou ZL, Ye ZN, Chen JH, Yuan JF, Cao FJ, Wang XB, Liu WC, Yu WX, Li XH*. Maslinic acid promotes autophagy by disrupting the interaction between Bcl2 and Beclin1 in rat phenochromocytoma PC12 cells. Oncotarget, 2017, 8(43):74527-74538
Yu WX, Lin CQ, Zhao Q, Lin XJ*, Dong XL*. Neuroprotection against hydrogen peroxide-induced toxicity by Dictyophora echinovolvata polysaccharide via inhibiting the mitochondria-dependent apoptotic pathway. Biomedicine & Pharmacotherapy, 2017, 88, 569-573
Zhao Q, Ye JL, Wei N, Fong CC, Dong XL*. Protection against MPP+-induced neurotoxicity in SH-SY5Y cells by tormentic acid via the activation of PI3-K/Akt/GSK3β pathway. Neurochemistry International, 2016, 97: 117-123
Dong XL, Li CM, Cao SS, Zhou LP, Wong MS*. A high saturated fat, high sucrose diet aggravates bone loss in ovariectomized female rats. Journal of Nutrition, 2016, 146(6): 1172-1179
Qiu ZC, Dong XL, Dai Y, Xiao GK, Wang XL, Wong KC, Wong MS*, Yao XS*. Discovery of a new class of cathepsin K inhibitors in Rhizoma Drynariae as potential candidates for the treatment of osteoporosis. International Journal of Molecular Sciences, 2016, 17, 2116
Dong XL, Zhang Y, Wong MS*. Estrogen deficiency-induced Ca balance impairment is associated with decrease in expression of epithelial Ca transport proteins in aged female rats. Life Sciences, 2014, 96(1-2): 26-32