Dr CHAN Wai-lun, Kulice Research Assistant Professor

Location Y820-B
Phone +852 3400 8880
mail wai-lun-kulice.chan@polyu.edu.hk

Open Platform for University Scholars
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Education and Academic Qualifications Doctor of Philosophy , National University of Singapore
Master of Arts in Communication, Hong Kong Baptist University
Bachelor of Science in Chemistry, Hong Kong Baptist University




Research Overview Our research focuses are (1) cooperative metal-organocatalysis in asymmetric natural product synthesis and solid-phase peptide functionalization; and (2) structure-based and multimodal imaging-guided targeted protein inhibition and degradation against cancer and dementia.




Academic and Professional Experiences Member of the Chinese Chemical Society (CCS) and Royal Society of Chemistry (RSC)



Research Interests
Asymmetric Organocatalysis
Natural Product Synthesis
Peptide Modification
Molecular Spectroscopy
Targeted Protein Degradation



Achievements

Representative Publications
Wu Y, Chau HF, Thor W, Chan KHY, Ma X, Chan WL,* Long NJ,* Wong KL.* Solid-phase peptide macrocyclization and multifunctionalization via dipyrrin construction. Angewandte Chemie International Edition. 2021;60:20301–20307.
Chan WL, Xie C, Lo WS, Bünzli JCG,* Wong WK,* Wong KL.* Lanthanide–tetrapyrrole complexes: synthesis, redox chemistry, photophysical properties, and photonic applications. Chemical Society Reviews. 2021;50:12189–12257.
Wu Y, Tam WS, Chau HF, Kaur S, Thor W, Aik WS, Chan WL,* Zweckstetter M,* Wong KL.* Solid-phase fluorescent BODIPY–peptide synthesis via in situ dipyrrin construction. Chemical Science. 2020;11:11266–11273.
(Co-first author) Zhang JX,^# Chan WL,^# Xie C,^# Zhou Y, Chau HF, Maity P, Harrison GT, Amassian A, Mohammed O, Tanner PA,* Wong WK,* Wong KL.* Impressive near-infrared brightness and singlet oxygen generation from strategic lanthanide–porphyrin double-decker complexes in aqueous solution. Light: Science & Applications. 2019;8:46.
Chan WL, Tang X, Zhang F, Quek G, Mei GJ,* Lu Y.* Phosphine-catalyzed (3+2) annulation of isoindigos with allenes: highly enantioselective formation of two vicinal quaternary stereogenic centers. Angewandte Chemie International Edition. 2019;58:6260–6264. (Selected as a Very Important Paper)
Ni H, Chan WL, Lu Y.* Phosphine-catalyzed asymmetric organic reactions. Chemical Reviews. 2018;118:9344–9411. (One of the top 3 most-read articles in Chemical Reviews in September/October 2018)
Han X,* Chan WL, Yao W, Wang Y, Lu Y.* Phosphine-mediated highly enantioselective spirocyclization with ketimines as substrates. Angewandte Chemie International Edition. 2016;55:6492–6496.
Chan WL, Liu Z, Lu S, Tanner PA,* Wong KL.* The reported anomalous emission intensity of the ⁵D₀ -> ⁷F₄ transition of Eu³⁺ in a molybdate double perovskite. Journal of Materials Chemistry C. 2015;3:960–963. (from themed collection: 2015 Journal of Materials Chemistry C Hot Papers)




Book Chapters
Persistent luminescence nanomaterials for biomedical applications: a quick grasp of the trend
Chan WL, Liu Z, Wong KL*.
Phosphors, Up Conversion Nano Particles, Quantum Dots and Their Applications
Volume 2, 2016