{ "chinesename
冯以文
title
Prof.
surname
FUNG
givenname
Erik
photo
../images/people/erikfung.png
education
BA, BS, MBChB(CUHK), PhD(Cantab), DABIM, DABIM(Cv)
post
Assistant Professor, Department of Medicine & Therapeutics
Faculty of Medicine, The Chinese University of Hong Kong
researcherid
expertise
Cardiovascular medicine
interest
Heart failure and inflammageing
tel
(852) 2647 6639
email
e.fung@cuhk.edu.hk
research
Prof Erik Fung's research interest centres on heart failure and frailty.
Over the past several years, he has established 3 longitudinal cohorts including older adults at risk of developing (preclinical) heart failure (UFO study), those with advanced heart failure (AHF and the SAHFIRE registry), and those with type 2 diabetes mellitus on chronic insulin therapy (HARE). Two of the studies have received funding support from HMRF and research award schemes. His group (Laboratory for Heart Failure + Circulation Research (LHFCR) located in the Li Ka Shing Institute of Health Sciences, Faculty of Medicine, PWH) has established expertise in biomarker profiling and NMR metabolomic analyses that have proven to be invaluable in providing novel insights. Ongoing work is underway to integrate cardiopulmonary fitness and unconventional metabolic measures to deepen profiling of individuals in the development multimodality biosignatures. These efforts may lead to an improved understanding of systemic physiological derangements that impair patients with heart failure, and potential targets for early disease detection, disease monitoring and therapeutic intervention.

selected
publication
Lee-Ling Lim, Eric SH Lau, Erik Fung, Heung-Man Lee, Ronald CW Ma, Claudia HT Tam, Willy KK Kong, Alex SW Ng, Elaine Chow, Andrew OY Luk, Alicia Jenkins, Juliana CN Chan, Alice PS Kong. Independent association of serum branched-chain amino acids with incident heart failure in type 2 diabetes: the Hong Kong Diabetes Register. Diabetes/Metabolism Research and Reviews 2020;36:e3253. doi: 10.1002/dmrr.3253. (IF 4.758)" },{ "publication
Erik Fung*, Leong Ting Lui, Finn Gustafsson, Forrest CF Yau, Jason CS Leung, Petri Wiklund, Marjo-Riitta J?rvelin, Peter S Macdonald, Jean Woo. Predicting 10-year mortality in older adults using VO2max, oxygen uptake efficiency slope and frailty class. European Journal of Preventive Cardiology 2020 Mar 30. doi: 10.1177/2435 (IF 7.804) " },{ "publication
Xiaobo Yang, Jean Woo, Leong Ting Lui, Qi Li, King Fai Cheng, Yiting Fan, Forrest Yau, Alex PW Lee, Jenny SW Lee, Erik Fung*. Cardiac manifestations of sarcopenia. Journal of Nutrition Health and Aging 2020;24:478–484. doi: 10.1007/s12603-020-1358-8 (IF 4.075)" },{ "publication
Jun Ni, Fuye Yang, Xiao-Ru Huang, Jinxiu Meng, Jiaoyi Chen, Michael Bader, Josef M Penninger, Erik Fung, Xue-Qing Yu, Hui Yao Lan. Dual deficiency of angiotensin-converting enzyme-2 and Mas receptor enhances angiotensin II-induced hypertension and hypertensive nephropathy. Journal of Cellular and Molecular Medicine 2020 Sep 24. doi: 10.1111/jcmm.15914. (IF 5.310)" },{ "publication
Chandu Sadasivan, Josie TY Chow, Bun Sheng, David Chan, Yiting Fan, Paul CL Choi, Jeffrey KT Wong, Mabel MP Tong, Tsz-Ngai Chan, Erik Fung, Kevin KH Kam, Joseph YS Chan, Wai K Chi, David I Paterson, Manohara Senaratne, Neil Brass, Gavin Y Oudit, Alex PW Lee. Screening for Fabry disease in patients with unexplained hypertrophic cardiomyopathy. PLoS ONE 2020;15:e0239675. doi: 10.1371/journal.pone.0239675. (IF 3.240) " },{ "publication
Ganesan Karthikeyan, Erik Fung, Roger S-Y Foo. An alternative hypothesis to explain disease progression in rheumatic heart disease. Circulation 2020;142:2091-2094. doi: 10.1161/CIRCULATIONAHA.120.050966. (IF 29.690) " },{ "publication
Sek-Ying Chair, Ho Yu Cheng, Kai Chow Choi, Elaine KC Siow, Xi Cao, Erik Fung*. Influenza-Associated Hospitalizations and Risk of Subsequent Heart Failure Hospital Admissions: A 20-Year Territorywide Registry Study in Hong Kong, China. American Journal of Epidemiology 2021;190:779-785. doi: 10.1093/aje/kwaa263. (IF 4.526) "},{ "publication
Yiting Fan, Tsz-Ngai Chan, Josie TY Chow, Kevin KH Kam, Wai-Kin Chi, Joseph YS Chan, Erik Fung, Mabel MB Tong, Jeffery KT Wong, Paul CL Choi, David KH Chan, Bun Sheng, Alex PW Lee. High prevalence of late-onset Fabry cardiomyopathy in a Cohort of 499 non-selective patients with left ventricular hypertrophy: The Asian Fabry Cardiomyopathy High-Risk Screening Study (FAME). Journal of Clinical Medicine 2021;10:2160. doi: 10.3390/jcm10102160. (IF 4.241)" },{ "publication
Polakit Teekakirikul, Wenjuan Zhu, George C Gabriel, Cullen B Young, Kylia Williams, Lisa J Martin, Jennifer C Hill, Tara Richards, Marie Billaud, Julie A Phillippi, Jianbin Wang, Yijen Wu, Tuantuan Tan, William Devine, Jiuann-huey Lin, Abha S Bais, Jonathan Klonowski, Anne Moreau de Bellaing, Ankur Saini, Michael X Wang, Leonid Emerel, Nathan Salamacha, Samuel K Wyman, Carrie Lee, Hung Sing Li, Anastasia Miron, Jingyu Zhang, Jianhua Xing, Dennis M McNamara, Erik Fung, Paul Kirshbom, William Mahle, Lazaros K Kochilas, Yihua He, Vidu Garg, Peter White, Kim L McBride, D Woodrow Benson, Thomas G Gleason, Seema Mital, Cecilia W Lo. Common deletion variants causing protocadherin-a deficiency contribute to the genetic etiology of bicuspid aortic valve and left-sided congenital heart disease. Human Genetics and Genomics Advances 2021;2:100037. doi: 10.1016/j.xhgg.2021.100037." },{ "publication
Erik Fung*, Ho Yu Cheng, Kai Choi Chow, David SC Hui, Cheng Yang, Sek Ying Chair. Differential Risks For Heart Failure Hospitalization Following Severe Respiratory Infections By Common Pathogens. European Journal of Preventive Cardiology 2021 (accepted 6 July 2021; IF 7.804)" },{ "publication
Xiaowei Ojanen, Runtan Cheng, Timo T?rm?kangas, Noa Rappaport, Tomasz Wilmanski, Na Wu, Erik Fung , Rozenn Nedelec, Sylvain Sebert, Dimitris Vlachopoulos, Wei Yan, Nathan D Price, Sulin Cheng, Petri Wiklund. Towards early risk biomarkers: serum metabolic signature in childhood predicts cardio-metabolic risk in adulthood. EBioMedicine 2021;72:103611" },{ "publication
Erik Fung, Leong-Ting Lui, Lei Huang, King Fai Cheng, Gloria HW Lau, Yi Ting Chung, Behzad Nasiri Ahmadabadi, Suyi Xie, Jenny SW Lee, Elsie Hui, Wing Yee So, Joseph JY Sung, Irwin King, William B Goggins, Queenie Chan, Marjo-Riitta J?rvelin, Ronald CW Ma, Elaine Chow, Timothy Kwok. Characterising frailty, metrics of continuous glucose monitoring, and mortality hazards in older adults with type 2 diabetes on insulin therapy (HARE): a prospective, observational cohort study. The Lancet Healthy Longevity 2021;2:e724-e735" }]}