{ "chinesename
陈重娥
title
Prof.
surname
Chan
givenname
Juliana CN
photo
../images/people/julianachan.png
education
MB ChB (Liverpool), MD (Liverpool), MRCP (UK), FRCP (Lond), FRCP (Edin), FRCP (Glasgow), FHKAM (Medicine)
post
Professor, Department of Medicine & Therapeutics
Head, Division of Clinical Pharmacology, Department of Medicine & Therapeutics
Director, Clinical Research Management Office
Director, Hong Kong Institute of Diabetes and Obesity
Faculty of Medicine, The Chinese University of Hong Kong
Honorary Consultant, Prince of Wales Hospital, Hospital Authority
researcherid
B-7918-2016
expertise
Diabetes and Endocrinology, Clinical Pharmacology
interest
Epidemiology, genetics, clinical trials and care models of diabetes and obesity
tel
(852) 3505 3138
email
jchan@cuhk.edu.hk
research
Professor Chan is a clinician scientist committed to translate evidence to practice and develop novel solutions for unmet needs. In the early 1990s, motivated by the observation of high prevalence of young-onset type 2 diabetes and renal disease, she set up the Hong Kong Diabetes Registry and multiple cohorts to define the epidemiology of diabetes in Chinese populations. These prospective cohorts have laid the foundation for an overarching program to use a multiomic approach to discover genetic variants of diabetes and its complications for personalized care. She is currently a member of an NIH funded Global Consortium to discover causal genes in type 2 diabetes in a multi-ethnic population.
Being one of the first Asian investigators involved in large scale multicenter studies in diabetes since 1990s, she has established the CUHK Diabetes Clinical Trial Centre which is one of the most active units in the region. She is a steering committee member of multicenter clinical trials including the ORIENT, EASIE, EXSCEL, ACE to study the effects of novel compounds on clinical outcomes in diabetes. Inspired by the low event rates within a clinical trial setting, in 2007, she founded the Asia Diabetes Foundation (www.adf.org.hk) to develop the first web-based Joint Asia Diabetes Evaluation (JADE) Program which uses logistics, collaborative care and information technology to promote quality improvement and collaborative research, now implemented in 11 Asian countries.
She has co-authored in 500 peer-reviewed articles, including editorials and commentaries, and 20 book chapters with over 10,000 citations. In 2009, she received the Chinese Women Physicians Association Intercontinental Innovation Award under the Chinese Ministry of Science and Technology. Through public private partnerships, she has successfully translated these knowledge to improve chronic/diabetes care for which the CUHK-PWH Diabetes Care and Research Team was selected as an International Diabetes Federation Centre of Education (www.idfce-hk.org) in 2011 for their commitment to use professional education and research to change practice and influence policy.

selected
publication
Yeung RO, Zhang YY, Luk A, Yang W, Sobrepena L, Yoon, KH, Aravind SR, Sheu W, Nguyen TK, Ozaki, R, Deerochanawong C, Tsang CC, Chan WB, Hong EG, Do TQ, Cheung Y, Brown N, Goh SY, Ma RC, Mukhopadhyay M, Ojha AK, Chakraborty S, Kong AP, Lau W, Jia W, Li W, Guo X, Bian R, Weng J, Ji L, Rosa MD, Toledo RM, Himathongkam T, Yoo SJ, Ho LLT, Chuang LM, Tutino G, Tong PC, So WY, Wolthers T, Ko G, Lyubomirsky G, Chan JC. Metabolic profiles and treatment gaps in young-onset type 2 diabetes in Asia (the JADE programme): a prospective cohort. Lancet Diabetes Endocrinology 2014 Jul 28. pii: S2213-8587(14)70137-8. doi: 10.1016/S2213-8587(14)70137-8." },{ "publication
Luk AO, Lau ES, So WY, Ma RC, Kong AP, Ozaki R, Chow FC, Chan JC. Prospective study on the incidences of cardiovascular-renal complications in Chinese patients with young-onset type 1 and type 2 diabetes. Diabetes Care. 2014;37:149-157" },{ "publication
Chan JC, Sui Y, Oldenburg B, Zhang Y, Chung HH, Goggins W, Au S, Brown N, Ozaki R, Wong RY, Ko GT, Fisher E, for the JADE and PEARL Project Team. Effects of telephone-based peer support in patients with type 2 diabetes mellitus receiving integrated care: A randomized clinical trial. JAMA Internal Medicine. 2014; 174:972-81." },{ "publication
Chan JC, Zhang YY, Ning G. Diabetes in China – a societal solution for a personal challenge. Lancet Diabetes Endocrinology 2014 Sep 10. pii: S2213-8587(14)70144-5. doi: 10.1016/S2213-8587(14)70144-5." },{ "publication
Aschner P*, Chan JC*, Owens DR, Picard S, Wang E, Dain MP, Pilorget V, Echtay A, Fonseca V. Insulin glargine versus sitagliptin in insulin-naive patients with type 2 diabetes mellitus uncontrolled on metformin (EASIE): A multicentre, randomised open-label trial. Lancet. 2012;379:2262-2269. (*Joint first author)" },{ "publication
Zhao HL, Sui Y, Qiao CF, Yip KY, Leung RK, Tsui SK, Lee HM, Wong HK, Zhu X, Siu JJ, He L, Guan J, Liu LZ, Xu HX, Tong PC, Chan JC. Sustained antidiabetic effects of a berberine-containing Chinese herbal medicine through regulation of hepatic gene expression. Diabetes. 2012;61:933-943." },{ "publication
Imai E, Chan JC*, Ito S, Yamasaki T, Kobayashi F, Haneda M, Makino H; ORIENT study investigators. Effects of olmesartan on renal and cardiovascular outcomes in type 2 diabetes with overt nephropathy: a multicentre, randomised, placebo-controlled study. Diabetologia. 2011;54:2978-86. (*joint first author)" },{ "publication
Ma RC, Tam CH, Wang Y, Luk AO, Hu C, Yang X, Lam V, Chan AW, Ho JS, Chow CC, Tong PC, Jia W, Ng MC, So WY, Chan JC. Genetic variants of the Protein Kinase C-beta 1 gene and development of end-stage renal disease in patients with type 2 diabetes. JAMA 2010;304:881-889." },{ "publication
Yang X, Ko GT, So WY, Ma RC, Yu LW, Kong AP, Zhao H, Chow CC, Tong PC, Chan JC. Associations of hyperglycemia and insulin usage with the risk of cancer in type 2 diabetes: The Hong Kong Diabetes Registry. Diabetes. 2010;59:1254-1260." },{ "publication
Chan JC, Malik V, Jia W, Kadowaki T, Yajnik CS, Yoon KH, Hu FB. Diabetes in Asia: Epidemiology, risk factors, and pathophysiology. JAMA 2009;301:2129-2140." }]}