{ "chinesename
于君
title
Prof.
surname
Yu
givenname
Jun
photo
../images/people/junyu2.png
education
MBBS, Master of Medicine, MD, PhD
post
Choh-Ming Li Professor of Medicine and Therapeutics
Assistant Dean, Faculty of Medicine
Director, The State Key Laboratory of Digestive Disease
Director, Institute of Digestive Disease
Director, The Research Laboratory of Digestive Disease
The Chinese University of Hong Kong
researcherid
D-8569-2015
expertise
Gastroenterology and Hepatology
interest
Molecular pathogenesis and biomarkers of gastrointestinal (GI) cancers (gastric, colon and liver); Gut microbiota in GI cancers; Non-alcohol steatohepatitis (NASH) and its associated liver cancer in relation to the molecular pathogenesis and treatment response
tel
(852) 3763 6099
email
junyu@cuhk.edu.hk
research
Her research interests being molecular pathogenesis, microbiome and diagnostic biomarkers and therapeutic targets of gastrointestinal cancers, elucidation of the role of gut microbiota in cancers, and molecular pathogenesis and treatment of fatty-liver disease and its associated liver cancer. She has over 450 peer-reviewed publications (116 papers IF>10, ISI citation 23,143, H-index=75). She has 25 granted patents on GI cancer biomarkers and treatment targets and 20 additional patents filed. Two licenced detection kits of stool biomarker miRNA92a for the early diagnosis of colorectal cancer and blood methylation DNA RNF180 for the diagnosis of gastric cancer have been approved by Chine FDA for clinical use. She obtained 30 prestigious awards, including The National Natural Science Award 2021; Top 10 People in Global Intestinal Bacteria Study-Enthusiasm Daily 2019 List; He Liang He Li Science and Technology Progress Award 2018; AGA Council Oncology Research Mentor Award 2017; The WuXi PharmaTech Life Science and Chemistry Award 2017; The National Natural Science Award 2016; The National Scientific and Technological Progress Award (Innovation Team) 2016; Croucher Senior Research Fellowship 2016; The National Science and Technology Progress Award 2012.
selected
publication
Liu D, Wong CC, Zhou Y, Li C, Chen H, Ji F, Go MY, Wang F, Su H, Wei H, Cai Z, Wong N, Wong VW, Yu J* (*corresponding author). Squalene epoxidase induces nonalcoholic steatohepatitis via binding to carbonic anhydrase 3 and is a therapeutic target. Gastroenterology. 2021 Feb 26:S0016-5085(21)00456-X. [IF for 2019: 17.373]." },{ "publication
Liu W, Zhang X, Xu H, Li S, Cheuk-Hay Lau H, Chen Q, Zhang B, Zhao L, Chen H, Jao-Yiu Sung J, Yu J*. Microbial community heterogeneity within colorectal neoplasia and its correlation with colorectal carcinogenesis. Gastroenterology. 2021 Feb 11:S0016-5085(21)00407-8. [IF for 2019: 17.373]." },{ "publication
Zhang X, Coker OO, Chu ES, Fu K, Lau HCH, Wang YX, Chan AWH, Wei H, Yang X, Sung JJY, Yu J*. Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites. Gut. 2021 Apr;70(4):761-774. [IF for 2019: 19.819]." },{ "publication
Chen H, Gao S, Liu W, Wong C-C, Wu J, Wu J, Liu D, Gou H, Kang W, Zhai J, Li C, Su H, Wang S, Soares F, Han J, He HH, Yu J*. RNA m6 A methyltransferase METTL3 facilitates colorectal cancer by activating m6 A-GLUT1-mTORC1 axis and is a therapeutic target. Gastroenterology 2021 Mar;160(4):1284-1300.e16.. [IF for 2019: 17.373]." },{ "publication
Wong CC*, Xu J, Bian X, Wu JL, Kang W, Qian Y, Li W, Chen H, Gou H, Liu D, Yat Luk ST, Zhou Q, Ji F, Chan LS, Shirasawa S, Sung JJ, Yu J*. In Colorectal Cancer Cells With Mutant KRAS, SLC25A22-Mediated Glutaminolysis Reduces DNA Demethylation to Increase WNT Signaling, Stemness, and Drug Resistance. Gastroenterology. 020 Dec;159(6):2163-2180.e6 [IF for 2019: 17.373]." },{ "publication
Coker OO, Kai Wu WK, Wong SH, Sung JJ, Yu J*. Altered Gut Archaea Composition and Interaction with Bacteria are Associated with Colorectal Cancer. Gastroenterology. 2020 2020 Oct;159(4):1459-1470.e5. [IF for 2019: 17.373]." },{ "publication
Zhao R, Coker OO, Wu J, Zhou Y, Zhao L, Nakatsu G, Bian X, Wei H, Chan AW, Sung JJ, Chan FK, El-Omar E, Yu J*. Aspirin Reduces Colorectal Tumor Development in Mice and Gut Microbes Reduce its Bioavailability and Chemopreventive Effects. Gastroenterology. 2020 Sep;159(3):969–983. e4. [IF for 2019: 17.373]." },{ "publication
Xia X, Wu WK, Wong SH, Liu D, Kwong TNY, Nakatsu G, Yan PS, Chuang YM, Chan MW, Coker OO, Chen Z, Yeoh YK, Zhao L, Wang X, Cheng WY, Chan MTV, Chan PKS, Sung JJY, Wang MH*, Yu J*. Bacteria pathogens drive host colonic epithelial cell promoter hypermethylation of tumor suppressor genes in colorectal cancer. Microbiome. 2020 Jul 16;8(1):108. [IF for 2019: 11.607]." },{ "publication
Liang JQ*, Li T, Nakatsu G, Chen YX, Yau TO, Chu E, Wong S, Szeto CH, Ng SC, Chan FKL, Fang JY, Sung JJY, Yu J*. A novel faecal Lachnoclostridium marker for the non-invasive diagnosis of colorectal adenoma and cancer. Gut. 2020 Jul;69(7):1248-1257. [IF for 2019: 19.819]." },{ "publication
Lau HCH, Kranenburg O, Xiao H, Yu J*. Organoid models of gastrointestinal cancers in basic and translational research. Nat Rev Gastroenterol Hepatol. 2020 Apr;17(4):203-222. Review. [IF for 2019: 29.848]." },{ "publication
Wang S, Huang J, Li C, Zhao L, Wong CC, Zhai J, Zhou Y, Deng W, Zeng Y, Gao S, Zhang Y, Wang G, Guan XY, Wei H, Wong SH, He HH, Shay JW, Yu J*. MAP9 loss triggers chromosomal instability, initiates colorectal tumorigenesis and is associated with poor survival of colorectal cancer patients. Clin Cancer Res. 2020 Feb 1;26(3):746-757. [IF for 2019: 10.107]." },{ "publication
Long X, Wong CC, Li T, Chu E, Szeto CH, Go MMY, Coker O, Chan A, Chan F, Sung JJY, Yu J*. Peptostreptococcus anaerobius promotes colorectal carcinogenesis and modulates tumor-immunity by activating PI3K/Akt signaling via its PCWBR2 adhesin. Nat Microbiol. 2019 Dec;4(12):2319-2330. [IF for 2019: 15.540]." },{ "publication
Wong SH, Yu J*. Gut microbiota in colorectal cancer: mechanisms of action and clinical applications. Nat Rev Gastroenterol Hepatol. 2019 Nov;16(11):690-704. Review. [IF for 2019: 29.848]." },{ "publication
Zhang X, Fan L, Wu J, Xu H, Leung WY, Fu K, Wu J, Liu K, Kwan M, Yang X, Han J, Ren J, Yu J*. Macrophage p38α promotes nutritional steatohepatitis through M1 polarization. J Hepatol. 2019 Jul;71(1):163-174. [IF for 2019: 20.582]." },{ "publication
Coker OO, Nakatsu G, Dai RZ, Wu WKK, Wong SH, Ng SC, Chan FKL, Sung JJY, Yu J*. Enteric fungal microbiota dysbiosis and ecological alterations in colorectal cancer. Gut. 2019 Apr;68(4):654-662. [IF for 2019: 19.819]." },{ "publication
Liang JQ, Teoh N, Xu L, Pok S, Li X, Chu ESH, Chiu J, Dong L, Arfianti E, Haigh WG, Yeh MM, Ioannou GN, Sung JJY, Farrell G*, Yu J*. Dietary cholesterol promotes steatohepatitis related hepatocellular carcinoma through dysregulated metabolism and calcium signaling. Nat Commun. 2018 Oct 26;9(1):4490. [IF for 2019: 12.121]." },{ "publication
Nakatsu G, Zhou H, Wu WKK, Wong SH, Coker OO, Dai Z, Li X, Szeto CH, Sugimura N, Yuen-Tung Lam T, Chi-Shing Yu A, Wang X, Chen Z, Chi-Sang Wong M, Ng SC, Chan MTV, Chan PKS, Leung Chan FK, Jao-Yiu Sung J, Yu J*. Alterations in Enteric Virome Associate With Colorectal Cancer and Survival Outcomes. Gastroenterology. 2018 Aug;155(2):529-541.e5. [IF for 2019: 17.373]." },{ "publication
Sun W, Zhang Y, Wong KC, Liu K, Yang Y, Wu B, Tong JH, Chan AW, Chan HL*, Yu J*. Increased expression of GATA Zinc Finger Domain Containing 1 via gene amplification promotes liver cancer by directly inducing PRL3. Hepatology. 2018 Jun;67(6):2302-2319. [IF for 2019: 14.679]." },{ "publication
Coker OO, Dai Z, Nie Y, Zhao G, Cao L, Nakatsu G, Wu WK, Wong SH, Chen Z, Sung JJ, Yu J*. Mucosal microbiome dysbiosis in gastric carcinogenesis. Gut. 2018 Jun;67(6):1024-1032. [IF for 2019: 19.819]." },{ "publication
Liu D, Wong CC, Fu L, Chen H, Zhao L, Li C, Zhou Y, Zhang Y, Xu W, Yang Y, Wu B, Cheng G, Lai PB, Wong N, Sung JJY, Yu J*. Squalene epoxidase drives NAFLD-induced hepatocellular carcinoma and is a pharmaceutical target. Sci Transl Med. 2018 Apr 18;10(437) (selected as Cover Story). [IF for 2019: 16.304]." }]}