{ "chinesename
张琳
title
Prof.
surname
ZHANG
givenname
Lin
photo
../images/people/linzhang.png
education
BM (AMU), PhD (CUHK)
post
Assistant Professor (non-clinical), Department of Medicine & Therapeutics
Faculty of Medicine, The Chinese University of Hong Kong
researcherid
O-9109-2015
expertise
Cell biology, Microbiology, Immunology
interest
Translational Microbiome Research
tel
(852) 3505 2062
email
linzhang@cuhk.edu.hk
research
Dr. Lin Zhang obtained her Ph.D. from School of Biomedical Sciences, CUHK in 2013 and received post-doctoral training in the Department of Medicine & Therapeutics (2013-2015) and later School of Biomedical Sciences (2015-2017) in CUHK and University of Edinburgh. Dr. Zhang joined the Department of Anaesthesia and Intensive Care as a Research Assistant Professor in 2017-2020. In August 2020, she joined the Department of Medicine & Therapeutics as an Assistant Professor. Dr. Zhang’s primary research interest is the crosstalk between microbes and the host, including antimicrobial peptide and autophagy. She is actively engaging in microbiome basic and translational microbiome research, with the aim to develop novel therapeutic approaches to restore the dysbiotic microbiota to prevent diseases.
She has published over 64 papers in peer-reviewed journals (13 of them as the first, co-first or corresponding author) and 3 book chapters, including papers in Annals of Oncology, Autophagy, Seminar of Cancer Biology, Seminar of Cell Developmental Biology, Journal of Pathology and Journal of Immunology. As Principal Investigator, Dr. Zhang obtained eight external competitive and six internal grants with a total amount of HK$10.43 million. She has received several awards including Fellowship of Hong Kong – Scotland Partners in Post-Doctoral Research 2016, Excellent Oral Presentation Award in Beijing 2013, Outstanding Oral Presentation Award in Hong Kong Pharmacology Society 2012 and Best Oral Presentation Award in SBS-CUHK 2012.

selected
publication
Hu W, Chan H, Lu L, Wong KT, Wong SH, Li MX, Xiao ZG, Cho CH, Gin T, Chan MTV, Wu WKK, Zhang L. (2020). Autophagy in intracellular bacterial infection. Seminars in Cell and Developmental Biology. 101:45-50." }, { "publication
Ho J, Li XC, Zhang L, Liang YH, Wong SH, Hu W, Yau JCW, Chan H, Chan MTV, Gin T, Tse G, Wu WKK. (2019) Translational genomics in pancreatic ductal adenocarcinoma: A review with re-analysis of TCGA dataset. Semin Cancer Biol 55:70-77." }, { "publication
Hu W, Zhang L, Li MX, Shen J, Liu XD, Xiao ZG, Wu DL, Ho IHT, Wu JCY, Cheung CKY, Zhang YC, Lau AHY, Ashktorab H, Smoot DT, Fang EF, Chan MTV, Gin T, Gong W, Wu WKK, Cho CH. (2019) Vitamin D3 activates the autolysosomal degradation function against Helicobacter pylori through the PDIA3 receptor in gastric epithelial cells. Autophagy 15(4):707-725." }, { "publication
Zhang L, Hu W, Cho CH, Chan FKL, Yu J, Fitzgerald RJ, Cheung CKY, Xiao ZG, Jing Shen J, Li LF, Li MX, Wu JCY, Ling TKW, Chan JYK, Ho K, Tse G, Ng SC, Yu S, Wang MHT, Gin T, Ashktorab H, Duane T. Smoot DT, Wong SH, Chan MTV, Wu WKK. (2018) Reduced lysosomal clearance of autophagosomes promotes survival and colonization of Helicobacter pylori. J Pathol 244(4):432-444." }, { "publication
Wang X, Li X, Zhang L, Wong SH, Wang MHT, Tse G, Dai RZW, Nakatsu G, Coker OO, Chen Z, Ko H, Chan JYK, Liu T, Cheng CHK, Cheng ASL, To KF, Plewczynski D, Sung JJY, Yu J, Gin T, Chan MTV, Wu WKK (2018) Oncogenes expand during evolution to withstand somatic amplification. Ann Oncol 29 (11):2254-2260." }, { "publication
Zhang L, Zhang YC, Wong SH, Law PTY, Zhao CS, Yu J, Chan MTV, Wu WKK. (2018) Common deregulation of seven biological processes by microRNAs in gastrointestinal cancers. Sci Rep 19; 8(1):3287." }, { "publication
Wong CMC, Zhang L, Wu WKK, Shen J, Chan RLY, Lu L, Hu W, Li MX, Li LF, Ren SX, Li YF, Li J, Cho CH (2017) Cathelicidin-Encoding Lactococcus lactis Promotes Mucosal Repair in Murine Experimental Colitis. J Gastroen Hepatol 32(3):609-619. " }, { "publication
Zhang L, Wu WKK, Gallo RL, Fang EF, Ling TKW, Shen J, Chan RLY, Lu L, Luo XM, Li MX, Chan KM, Yu J, Wong VWS, Ng SC, Wong SH, Chan FKL, Sung JJY, Chan MTV, Wu WKK, Cho CH (2016). Critical Role of Antimicrobial Peptide Cathelicidin for Controlling Helicobacter pylori Survival and Infection. J Immunol 15; 196 (4):1799-809." }, { "publication
Zhang L, Sung JJY, Yu J, Ng SC, Wong SH, Cho CH, Chan FKL, Wu WKK (2014). Xenophagy in Helicobacter pylori- and Epstein-Barr virus-induced gastric cancer. J Pathol 233(2):103-12." }, { "publication
Zhang L, Yu J, Wong CCM, Ling TKW, Li ZJ, Chan KM, Ren SX, Shen J, Chan RLY, Lee CC, Li MSM, Cheng ASL, To KF, Gallo RL, Sung JJY, Wu WKK, Cho CH (2013). Cathelicidin protects against Helicobacter pylori colonization and the associated gastritis in mice. Gene Ther 20(7):751-760." }]}