{ "chinesename
王善斌
title
Prof.
surname
Ong
givenname
Sang-Bing
photo
../images/people/sangbingong.png
education
Hitachi Fellow (Sapporo Medical University, Hokkaido, Japan)
Khoo Teck Puat Fellow (Duke-NUS Medical School, Singapore)
Postdoctoral Research Scholar (UCSD, USA)
PhD Medicine (UCL, UK) *BBSRC-Hatter Dorothy Hodgkin Scholar
MSc Medical Molecular Biology (Merit) (Westminster, UK) *Westminster Vice-Chancellor’s Scholar
BSc Biotechnology (1st Class Hons) (UPM, Malaysia) *Malaysia Public Services Department Scholar
post
Assistant Professor, Department of Medicine & Therapeutics
Faculty of Medicine, The Chinese University of Hong Kong (CUHK)
Centre for Cardiovascular Genomics & Medicine (CCGM), Lui Che Woo Institute of Innovative Medicine, CUHK
Hong Kong Hub of Paediatric Excellence (HK HOPE), Hong Kong Children's Hospital (HKCH)
researcherid
expertise
Cardiac mitochondrial dynamics, Cardioprotection, Cardiac ischemia-reperfusion injury
interest
Modulation of cardiac mitochondrial dynamics to protect the heart
tel
(852) 3513 3157
email
sangbingong@cuhk.edu.hk
research
Our laboratory – Mitochondria@HeartHK, based at the Chinese University of Hong Kong (CUHK) is focused on studying the roles of mitochondrial dynamics encompassing the changes in mitochondrial shapes (morphology) and movement (positioning), in protecting the heart against injury and death. To achieve this overarching aim, we utilise a range of genetic and pharmacological approaches to modulate mitochondrial dynamics in different cellular and animal models of cardiovascular disorders.

selected
publication
Sang-Bing Ong*, Xiu-Yi Kwek, Khairunnisa Katwadi, Sauri Hernandez-Resendiz, Gustavo E. Crespo-Avilan, Nur Izzah Ismail, Ying-Hsi Lin, En Ping Yap, Song-Yi Lim, K P Myu Mai Ja, Chrishan J.A. Ramachandra, Nicole Tee, Jin Jiat Toh, Winston Shim, Philip Wong, Hector A. Cabrera-Fuentes* and Derek J Hausenloy. ‘Targeting mitochondrial fission using mdivi-1 in a clinically relevant large animal model of acute myocardial infarction: a pilot study.’ International Journal of Molecular Sciences 20(16), 3972, 2019. *Co-Corresponding authors"},{ "publication
Sang-Bing Ong*, Won Hee Lee*, Ning-Yi Shao, Nur Izzah Ismail, Khairunnisa Katwadi, Mim-Mim Lim, Xiu-Yi Kwek, Nathaly Anto Michel, Jiajun Li, Jordan Newson, Soroush Tahmasebi, Jalees Rehman, Kazuki Kodo, Hye Ryoun Jang, Sang-Ging Ong. ‘Calpain inhibition restores autophagy and prevents mitochondrial fragmentation in a human iPSC model of diabetic endotheliopathy.’ Stem Cell Reports 12(3):597-610, 2019. *Joint first authors"},{ "publication
Sang-Bing Ong, Siavash Beikoghli Kalkhoran, Sauri Hernández-Reséndiz, Parisa Samangouei, Sang-Ging Ong, Derek J Hausenloy. ‘Mitochondrial-Shaping Proteins in Cardiac Health and Disease - the Long and the Short of It!’ Cardiovascular Drugs & Therapy 31 (1): 87-107, 2017."},{ "publication
Sang-Bing Ong*, Derek J Hausenloy. ‘Mitochondrial dynamics as a therapeutic target for treating cardiac disease’ In: Pharmacology of Mitochondria (Handbook of Experimental Pharmacology) 240: 251-279 Springer Press – Germany. ISBN 978-3-319-57311-3 (Print) 978-3-319-57313-7 (Online), 2017. *Corresponding author"},{ "publication
Amabel M. Orogo, Eileen R. Gonzalez, Dieter A. Kubli, Igor L. Baptista, Sang-Bing Ong, Tomas A. Prolla, Mark A Sussman, Anne N. Murphy, ?sa B. Gustafsson. ‘Accumulation of mitochondrial DNA mutations disrupts cardiac progenitor cell function and survival.’ Journal of Biological Chemistry 290 (36): 22061-22075, 2015."},{ "publication
Sang-Bing Ong, Siavash Beikoghli Kalkhoran, Hector A. Cabrera-Fuentes, Derek J Hausenloy. ‘Mitochondrial fusion and fission proteins as novel targets in cardiovascular disease.’ European Journal of Pharmacology 763 (Pt A): 104-114, 2015."},{ "publication
Sang-Bing Ong, Andrew R Hall, Rachel K Dongworth, Siavash Kalkhoran, Aswin Pyakurel, Luca Scorrano, Derek J Hausenloy. ‘Akt protects the heart against ischaemia-reperfusion injury by modulating mitochondrial morphology.’ Thrombosis & Haemostasis 113(3): 513-521, 2015. (** Article recommended by Faculty of 1000 Prime)"},{ "publication
Sang-Bing Ong, Andrew R. Hall, Derek J. Hausenloy. ‘Mitochondrial dynamics in cardiovascular health and disease.’ Antioxidant and Redox Signaling 19(4): 400-414, 2013."},{ "publication
Sang-Bing Ong, ?sa B. Gustafsson. ‘New roles of mitochondria in cell death in the reperfused myocardium.’ Cardiovascular Research 94 (2): 190-196, 2012.IF = 5.465 (Cited by 105)"},{ "publication
Sang-Bing Ong, Sapna Subrayan, Shiang Y Lim, Derek M Yellon, Sean M Davidson, Derek J Hausenloy. ‘Inhibiting mitochondrial fission protects the heart against ischaemia/reperfusion injury.’ Circulation 121 (18): 2012 – 2022, 2010.
(** Article selected for the Faculty of 1000 Biology)
(** Circulation Editors' Picks: Most Read Articles on Studies Performed in an Animal Model)
(** Circulation Editors' Picks: Most Read Articles in Molecular Cardiology)"}]}