{ "title
Prof.
surname
C. ZEBROWSKI
givenname
David
photo
../images/people/zebrowski.png
education
B.Sc. (Carnegie Mellon University), Ph.D. (Rutgers Medical School)
post
Assistant Professor, Department of Medicine & Therapeutics,
Center for Cardiovascular Genomics and Medicine
Faculty of Medicine, The Chinese University of Hong Kong
researcherid
expertise
Cardiovascular medicine
interest
Cardiomyocyte differentiation
Cardiac regeneration
Metabolic remodeling in Heart Failure
Diastolic dysfunction in Heart Failure
tel
(852) 3513 3163
email
davidzebrowski@cuhk.edu.hk
research
Prof. David Zebrowski received his BSc from Carnegie Mellon University (USA) and PhD from Rutgers Medical School (USA) before going on to pursue his postdoctoral studies at Harvard Medical School/Children′s hospital Boston/Department of Pediatric Cardiology (USA) and then at the Max Planck Institute of Heart and Lung Research/Uni-Klinikum Erlangen (Germany). Upon completion of his academic fellowships, Prof. Zebrowski turned his career interest towards the pharmaceutical industry where he identified and developed heart failure targets and therapeutics first at AstraZeneca (Sweden) and then Novo Nordisk (Denmark). In 2019, Prof. Zebrowski joined the Department of Medicine & Therapeutics and the Centre of Cardiovascular Genomics and Medicine at the Chinese University of Hong Kong where he conducts both basic and translational cardiovascular research. His basic research currently centers on the developmental mechanisms underlying mammalian cardiomyocyte terminal differentiation while his translational research interests include the identification of therapeutics to address i) cardiac regeneration, ii) maladaptive metabolic remodeling, and iii) diastolic dysfunction during heart failure.

selected
publication
DC Zebrowski, CH Jensen, F Ferrazzi, SP Sheikh, BD Polizzotti, DC Andersen, and FB Engel. “Cardiac injury of the newborn mammalian heart accelerates cardiomyocyte terminal differentiation”. Scientific Reports. 2017. August 21."},{ "publication
DC Zebrowski, R Becker, and FB Engel. “Towards regenerating the mammalian heart: Challenges in evaluating experimentally induced adult mammalian cardiomyocyte proliferation”. American Journal of Physiology-Heart. 2016. May 1. (Review)."},{ "publication
CC Wu, F Kruse, MD Vasudevarao, JP Junker, DC Zebrowski, K Fischer, ES Noel, D Grün, E Berezikov, FB Engel, A van Oudenaarden, G Weidinger, and J Bakkers. “Spatially resolved genome-wide transcriptional profiling identifies BMP signaling as essential regulator of zebrafish cardiomyocyte regeneration”. Developmental Cell. 2016 Dec 31."},{ "publication
C Andersen, CH Jensen, C Baun, S Hvidsten, DC Zebrowski, FB Engel, and SP Sheikh. “Persistent scarring and dilated cardiomyopathy suggest incomplete regeneration of the apex resected neonatal mouse myocardium - A 180 days follow up study.” Journal of Molecular and Cellular Cardiology. 2015 Nov 30."},{ "publication
MH Soonpaa, DC Zebrowski, C Platt, A Rosenzweig, FB Engel, and L Field. “Cardiomyocyte cell cycle activity during preadolescence.” Cell. 2015 Nov 5."},{ "publication
DC Zebrowski, S Vergarajauregui, CC Wu, R Becker, Leone, T Piatkowski, S Hirth, F Ricciardi, N Falk, A Giessl, S Just, T Braun, G Weidinger, FB Engel. “Developmental alterations in centrosome integrity contribute to the post-mitotic state of mammalian cardiomyocytes.” eLife. 2015 Aug 6."},{ "publication
DC Zebrowski and FB Engel. “The Cardiomyocyte Cell Cycle in Hypertrophy, Tissue Homeostasis, and Regeneration”. Reviews in Physiology, Biochemistry, and Pharmacology. 2013 Apr 19. (Review)."},{ "publication
DC Zebrowski, RR Alcendor, LA Kirshenbaum, and J Sadoshima. “Caspase-3 mediated cleavage of MEKK1 promotes p53 transcriptional activity.” Journal of Molecular and Cellular Cardiology. 2006 Jan 19."},{ "publication
C Morisco, DC Zebrowski, DE Vatner, SF Vatner, and J Sadoshima. “β-Adrenergic cardiac hypertrophy is mediated primarily by the beta1-subtype in the rat heart.” Journal of Molecular and Cellular Cardiology. 2001 March."},{ "publication
C Morisco, DC Zebrowski, G Condorelli, P Tsichlis, SF Vatner, and J Sadoshima. “The Akt-glycogen synthase kinase 3β pathway regulates transcription of atrial natriuretic factor induced by β-adrenergic receptor stimulation in cardiac myocytes.” Journal of Biological Chemistry. 2000 May 12."}]}