{ "chinesename
张翔
title
Dr.
surname
Zhang
givenname
Jennifer X
photo
../images/people/jenniferzhang.png
education
MBBS (XJTU), MMed (XJTU), PhD (CUHK)
post
Research Assistant Professor, Department of Medicine & Therapeutics
Faculty of Medicine, The Chinese University of Hong Kong
researcherid
N-7918-2015
expertise
Gastroenterology and Hepatology
interest
The mechanism, diagnosis and therapeutic targets of non-alcoholic fatty liver diseases and its associated liver cancer. Gut microbiome and molecular alterations in colorectal cancer and hepatocellular carcinoma.
tel
(852) 3763 6102
email
jenniferzhang@link.cuhk.edu.hk
research
Dr. Zhang’s research focuses on the mechanism, diagnosis and treatment of non-alcoholic steatohepatitis (NASH) and its associated liver cancer. She has published over 30 papers in international peer-reviewed SCI journals, including Journal of Hepatology, Gut, Gastroenterology and Cell research. She has obtained research awards including the National Scholar Award in United European Gastroenterology Week 2015, Best Poster Award in the 21st ASM of Hong Kong Society of Flow Cytometry, 2nd prize at the CIGI Best Abstract Award, Yu To Sang Yu Shing Keung Memorial Fund Scholarship 2012/2013. She is a member of the American Gastroenterological Association, China Anti-Cancer Association (Tumour Microecology), Chinese Society of Management of Chronic Diseases, Hong Kong Immunology Association, Hong Kong Flow Cytometry Association, Youth Committee in Cross-Strait Digestive Association. Dr Zhang serves as an editorial board member of Front. Oncol. and reviewers for several journals.

selected
publication
Zhang X, Coker OO, Chu ESH, Fu K, Lau HCH, Wang YX, Chan AWH, Wei H, Yang X, Sung JJY, Yu J. Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites. Gut 2020 Jul; Epub ahead of print. doi:10.1136/ gutjnl-2019-319664." },{ "publication
Zhang X, Fan L, Wu J, Xu H, Leung WY, Fu K, Wu J, Liu K, Kwan M, Yang X, Han J, Ren J, Yu J. Macrophage p38α promotes nutritional steatohepatitis through M1 polarization. J Hepatol 2019;71(1):163-174." },{ "publication
Han J, Zhang X, Lau JKC, Fu K, Lau HCH, Xu W, Chu ESH, Lan H, Yu J. Bone marrow-derived macrophage contributes to fibrosing steatohepatitis through activating hepatic stellate cells. J Pathol 2019;248(4):488-500." },{ "publication
Wang X, Zhang X, Chu ESH, Chen X, Kang W, Wu F, To KF, Wong VWS, Chan HLY, Chan MTV, Sung JJY, Wu WKK, Yu J. Defective lysosomal clearance of autophagosomes and its clinical implications in non-alcoholic steatohepatitis. FASEB J 2018;32(1):37-51." },{ "publication
Zhang X, Wu WKK, Xu W, Man K, Wang X, Han J, Leung WY, Wu R, Liu K, Yu J. C-X-C Motif Chemokine 10 Impairs Autophagy and Autolysosome Formation in Non-alcoholic Steatohepatitis. Theranostics 2017;7(11):2822-2836." },{ "publication
Du J, Zhang X, Han J, Man K, Zhang Y, Chu ESH, Nan Y, Yu J. Pro-inflammatory CXCR3 impairs mitochondrial function in experimental non-alcoholic steatohepatitis. Theranostics 2017;7(17):4192-4203."},{ "publication
Wong SH, Zhao L, Zhang X, Nakatsu G, Han J, Xu W, Xiao X, Kwong TN, Tsoi H, Wu WK, Benhua Z, Chan FK, Sung JJ, Wei H, Yu J, Gavage of Fecal Samples From Patients with Colorectal Cancer Promotes Intestinal Carcinogenesis in Germ-free and Conventional Mice. Gastroenterology 2017;153(6):1621-1633.e6."},{ "publication
Xu W, Zhang X, Wu JL, Fu L, Liu K, Liu D, Chen GG, Lai PB, Wong N, Yu J. O-GlcNAc transferase promotes fatty liver-associated liver cancer through inducing palmitic acid and activating endoplasmic reticulum stress. J Hepatol 2017;67(2):310-320."},{ "publication
Zhang X, Han J, Man K, Li X, Du J, Chu ES, Go MY, Sung JJ, Yu J. CXC chemokine receptor 3 promotes steatohepatitis in mice through mediating inflammatory cytokines, macrophages and autophagy. J Hepatol 2016;64(1):160-170." },{ "publication
Zhang X, Shen J, Man K, Chu ES, Yau TO, Sung JC, Go MY, Deng J, Lu J, Wong VW, Sung JJ, Farrell G, Yu J. CXCL10 plays a key role as an inflammatory mediator and a non-invasive biomarker of nonalcoholic steatohepatitis. J Hepatol 2014;61(6):1365-1375." }]}