Chun Kwok Wong 黄振国
Professor 教授

ck-wong@cuhk.edu.hk


Biography
Professor Wong is currently Professor in Department of Chemical Pathology, Director of Institute of Chinese Medicine and Assistant Director of State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants, CUHK. He obtained his PhD degree in Immunology from the Department of Biochemistry, CUHK in 1993. This was followed by postdoctoral appointments at the Centre for Biochemical and Biophysical Science and Medicine of the Brigham and Women's Hospital, Harvard Medical School (1994-1996), and the Pulmonary and Critical Care Unit at the Massachusetts General Hospital, Harvard Medical School, USA (1996-1997). He was appointed postdoctoral research fellow in the Department of Chemical Pathology, CUHK from August 1997 to June 2000, Scientific Officer in July 2000, Associate Professor in February 2001, and Professor in August 2009.







Professor Wong is involved in teaching medical students, Faculty of Medicine and MSc course, School of Life Sciences. Currently, Professor Wong is supervising five full-time PhD students. He also serves as Honorary Scientific Officer (Medical) in the diagnostic clinical chemistry laboratory at Prince of Wales Hospital.


Professor Wong has been the President of Hong Kong Society for Immunology and Hong Kong Society of Flow Cytometry, current Treasurer of the Hong Kong Society for Immunology and Fellow of Royal Society of Biology (FRSB), UK.




Research Interests:
His immunology research includes (1) the elucidation of cytokine and chemokine network and intracellular signal transductions of immune effector cells including eosinophils, lymphocytes, mast cells, basophils and dendritic cells in inflammatory diseases, with recent emphasizing in pattern recognition receptors mediated innate immunity and immunoregulatory cytokines, (2) the immunopathological mechanisms of allergic diseases, autoimmune diseases, infectious diseases and diabetes mellitus, with interdepartmental collaboration and (3) the immunomodulatory, anti-tumor and anti-allergic activities of traditional Chinese medicine. High-throughput immunoassay, flow cytometry, mass cytometry, molecular technology, proteomic method and transgenic murine model have been applied in above studies. He has published 240 refereed papers in international journals and book chapters (Web of Science Core Collection, H-index = 49).



Illustrations of the 2 major research areas:
(1) Cytokine and chemokine network
(2) Intracellular signal transductions













Ten Representative Publications in 2010-2020:

Wong CK, Hu SQ, Cheung PFY and Lam CWK. Thymic Stromal Lymphopoietin Induces Chemotactic and Pro-survival Effects in Eosinophils: Implications in Allergic Inflammation. Am J Respir Cell Mol Biol 2010; 43: 305-15.

Wong CK, Cao J, Yin YB and Lam CWK. IL-17A activation on bronchial epithelial cells and basophils: a novel inflammatory mechanism. Eur Respir J 2010; 35: 883-93.

Wong CK, Chen DP, Tan LS, Li EK, Yin YB, and Lam CW. Effects of inflammatory cytokine IL-27 on the activation of fibroblast-like synoviocytes in rheumatoid arthritis. Arthritis Res Ther 2010; 12: R129.

Wong CK, Dong J, Lam CWK. Molecular mechanisms regulating the synergism between IL-32γ and NOD for the activation of eosinophils. J Leukoc Biol 2014; 95:631-642.

Dong J, Wong CK (correspondence author), Cai Z, Jiao D, Chu M and Lam CWK. Amelioration of allergic airway inflammation in mice by regulatory IL-35 through dampening inflammatory dendritic cells. Allergy 2015; 70: 921-932.

Jiao D, Wong CK (correspondence author), Qiu HN, Dong J, Cai Z, Chu M, Hon KL, Tsang MSM, Lam CWK. NOD2 and TLR2 ligands trigger the activation of basophils and eosinophils by interacting with dermal fibroblasts in atopic dermatitis-like skin inflammation. Cell Mol Immunol 2016; 13: 535-550.

Jiao D, Wong CK (correspondence author), Tsang MS, Chu IM, Liu D, Zhu J, Chu M, Lam CWK. Activation of Eosinophils Interacting with Bronchial Epithelial Cells by Antimicrobial Peptide LL-37: Implications in Allergic Asthma. Sci Rep 2017; 7:1848.

Zhu J, Dong J, Ji L, Jiang P, Leung TF, Liu D, Ng LG, Tsang MSM, Jiao D, Lam CWK, Wong CK (correspondence author). Anti-allergic inflammatory activity of interleukin-37 is mediated by novel signaling cascades in human eosinophils. Front Immunol 2018; 9:1445.

Hou T, Sun X, Zhu J, Hon KL, Jiang P, Chu IM, Tsang MS, Lam CW, Zeng H, Wong CK (correspondence author). IL-37 ameliorating allergic inflammation in atopic dermatitis through regulating microbiota and AMPK-mTOR signaling pathway-modulated autophagy mechanism. 2020. Front Immunol 2020; 11: 752.


Sun X, Hou T, Cheung EC, Iu TN, Tam VW, Chu IM, Tsang MS, Chan PK, Lam CW, Wong CK (correspondence author). Anti-inflammatory Mechanisms of the Novel Cytokine Interleukin-38 in Allergic Asthma. Cell Mol Immunol 2020; 17:631-646.