Jason Liao 廖晋粤
Research Assistant Professor 研究助理教授

liaojinyue@cuhk.edu.hk


Biography


Dr. Jinyue Liao received his bachelor's degree in Basic Medicine from Fudan University in 2007. During that time, he was trained in biology, biochemistry, genetics and medicine. Afterward, he received his master's degree in Biochemistry from The Hong Kong University of Science and Technology in 2012. Thereafter, he received his Ph.D. in Biomedical Sciences from The Chinese University of Hong Kong in 2017 and had postdoctoral training at the School of Biomedical Sciences, The Chinese University of Hong Kong from 2017 to 2021. His research focused on the analysis of gene regulatory networks that define the identity, development, and function of cells with a particular focus on germ cell development, regeneration and aging. His research integrates both wet (experimental) and dry (computational) components. The tools of his work include RNA-seq for gene expression, ChIP-seq for histone modifications, ATAC-seq for chromatin accessibility, and single-cell RNA-seq and single-cell ATAC-seq for individual transcriptomes and epigenomes from single cells. His current research focuses on understanding regulatory mechanisms of aging and regeneration with cutting-edge single-cell genomics technologies.







Selected publications:

J. Liao, H. C. Suen, A. C. S. Luk, L. Yang, A. W. T. Lee, H. Qi, T.-L. Lee, Transcriptomic and epigenomic profiling of young and aged spermatogonial stem cells reveals molecular targets regulating differentiation. PLoS Genet. 17, e1009369 (2021).

A. W. T. Lee, J. K. W. Ng, J. Liao, A. C. Luk, A. H. C. Suen, T. T. H. Chan, M. Y. Cheung, H. T. Chu, N. L. S. Tang, M. P. Zhao, Q. Lian, W. Y. Chan, D. Y. L. Chan, T. Y. Leung, K. L. Chow, W. Wang, L. H. Wang, N. C. H. Chen, W. J. Yang, J. Y. Huang, T. L. Lee, Single-cell RNA sequencing identifies molecular targets associated with poor in vitro maturation performance of oocytes collected from ovarian stimulation. Hum. Reprod. 36, 1907–1921 (2021).

J. Liao, H. C. Suen, S. Rao, A. C. S. Luk, R. Zhang, A. W. T. Lee, T. H. T. Chan, M. Y. Cheung, H. T. Chu, H. C. So, R. M. Hobbs, T. L. Lee, The single-cell epigenetic regulatory landscape in mammalian perinatal testis development. BioRxiv (2021), doi:10.1101/2021.03.17.435776.

J. Liao, H. C. Suen, Alfred Chun Shui Luk, Annie Wing Tung Lee, Judy Kin Wing Ng, Ting Hei Thomas Chan, M. Y. Cheung, David Yiu Leung Chan, T. C. Li, H. Qi, W.-Y. Chan, R. M. Hobbs, T. L. Lee, scATAC-Seq reveals epigenetic heterogeneity associated with an EMT-like process in male germline stem cells and its regulation by G9a. bioRxiv (2020).

H. C. Suen, Y. Qian, J. Liao, C. S. Luk, W. T. Lee, J. K. W. Ng, T. T. H. Chan, H. W. Hou, I. Li, K. Li, W.-Y. Chan, B. Feng, L. Gao, X. Jiang, Y. H. Liu, J. A. Rudd, R. Hobbs, H. Qi, T. K. Ng, H. K. Mak, T.-L. Lee, Transplantation of Retinal Ganglion Cells Derived from Male Germline Stem Cell as a Potential Treatment to Glaucoma. Stem Cells Dev. 28, 1365–1375 (2019).

C. Meng, J. Liao, D. Zhao, H. Huang, J. Qin, T.-L. Lee, D. Chen, W.-Y. Chan, Y. Xia, L3MBTL2 regulates chromatin remodeling during spermatogenesis. Cell Death Differ. 26, 2194–2207 (2019).

J. Liao, S. H. Ng, A. C. Luk, H. C. Suen, Y. Qian, A. W. T. Lee, J. Tu, J. C. L. Fung, N. L. S. Tang, B. Feng, W. Y. Chan, P. Fouchet, R. M. Hobbs, T. L. Lee, Revealing cellular and molecular transitions in neonatal germ cell differentiation using single cell RNA sequencing. Development. 146 (2019), doi:10.1242/dev.174953.

Y. Qian, J. Liao, A. H. C. Suen, A. W. T. Lee, H. S. Chung, N. L. S. Tang, K. L. Chow, Q. Cao, Y. L. Yip, T. Y. Leung, W.-Y. Chan, D. Y. L. Chan, T. C. Li, T.-L. Lee, Comparative analysis of single-cell parallel sequencing approaches in oocyte application. Int. J. Biochem. Cell Biol. 107, 1–5 (2019).

P. M.-K. Tang, S. Zhou, C.-J. Li, J. Liao, J. Xiao, Q.-M. Wang, G.-Y. Lian, J. Li, X.-R. Huang, K.-F. To, C.-F. Ng, C. C.-N. Chong, R. C.-W. Ma, T.-L. Lee, H.-Y. Lan, The proto-oncogene tyrosine protein kinase Src is essential for macrophage-myofibroblast transition during renal scarring. Kidney Int. 93, 173–187 (2018).

J. Tu, S. H. Ng, A. C. S. Luk, J. Liao, X. Jiang, B. Feng, K. K. Lun Mak, O. M. Rennert, W.-Y. Chan, T.-L. Lee, MicroRNA-29b/Tet1 regulatory axis epigenetically modulates mesendoderm differentiation in mouse embryonic stem cells. Nucleic Acids Res. 43, 7805–7822 (2015).

V. W. S. Ho, M.-K. Wong, X. An, D. Guan, J. Shao, H. C. K. Ng, X. Ren, K. He, J. Liao, Y. Ang, L. Chen, X. Huang, B. Yan, Y. Xia, L. L. H. Chan, K. L. Chow, H. Yan, Z. Zhao, Systems-level quantification of division timing reveals a common genetic architecture controlling asynchrony and fate asymmetry. Mol. Syst. Biol. 11, 814 (2015).