Fernand M. LAI（黎永祥）MD (Lyon), FRCPA, FHKCPath, FHKAM (Path), MScFI (Leicester)fmlai@cuhk.edu.hk Major Research Interests:

The diagnostic aspects: a) clinico-pathological studies of glomerulonephritis in Hong Kong; b) pathological prognostic indicators of IgA nephropathy; c) grading of lupus nephritis for therapy & therapeutic trials; d) diagnostic approach to HBV-related glomerulonephritis; e) renal allograft, Banff classification revisited, f) characterization of the renal lesion of pre-diabetes or insulin resistance state.

The pathogenetic aspects: mechanisms leading to the development of Thick GCBM: renal lesion of pre-diabetes or insulin resistance state.

Uropathology: a) pathogenetic and prognostic factors in prostatic carcinoma in Hong Kong Chinese; b) prognostic factors in.renal cell carcinoma.

Soft tissues tumors: a) vascular neoplasms; b) post-transplantation tumors.

RGC Earmarked Grant
Grant # CUHK 4411/05M : F. Mac-Moune Lai (PI), Juliana Chan, CC Szeto, KF To. Metabolic Characterization of a Pre-Diabetes Renal Lesion - Isolated Thick Glomerular Capillary Basement Membrane (TGCBM), a Marker for the Prevention of Diabetic Nephropathy?. CUHK 4411/05M – 840,000$

PublicationsChan RW, Mac-Moune Lai F, Li EK, Tam LS, Chow KM, Li PK, Szeto CC. Expression of T-bet, a type 1 T-helper cell transcription factor, in the urinary sediment of lupus patients predicts disease flare. Rheumatology (Oxford) 46:44-48, 2007

Chow KM, Szeto CC, Mac-Moune Lai F, Poon P, Wong TY, Li PK. Genetic polymorphism of vascular endothelial growth factor: impact on progression of IgA nephropathy. Ren Fail 28:15-20, 2006

Szeto CC, Chow KM, Lai KB, Szeto CYK, Chan RW, Kwan BCH, Chung KY, Li PKT, Mac-Moune Lai F. mRNA Expression of Target Genes in the Urinary Sediment as a Noninvasive Prognostic Indicator of CKD Am Journal Kidney Dis 47:578-586, 2006

Sun ZJ, Zhang L, Zhang WF, Chen XM, Mac-Moune Lai F, Zhao YF. Kaposiform Hemangioendothelioma involving the neck. Oral Oncology Extra 42:60-65, 2006

Szeto CC, Lai KB, Chow KM, Szeto CY, Yip TW, Woo KS, Li PK, Mac-Moune Lai F. Messenger RNA expression of glomerular podocyte markers in the urinary sediment of acquired proteinuric diseases. Clin Chim Acta 361: 182-190, 2005

Tang S, Mac-Moune Lai F, Lui YH, Tang CSO, Kung NNS, Leung VKS, Ho YW, Chan KW, Leung JCK, Lai KN. Lamivudine in hepatitis B-associated membranous nephropathy. Kidney Int 68:1750-1758, 2005

Mac-Moune Lai F, Szeto CC, Choi PCL, Ho KKL, Tang NLS, Chow KM, Li PKT, To KF Isolate Diffuse Thickening of Glomerular Capillary Basement Membrane: A Renal Lesion in Prediabetes? Mod Pathol 17:1506-1512, 2004

Lyons LL, North PE, Mac-Moune Lai F, Stoler MH, Folpe AL, Weiss SW. Kaposiform hemangioendothelioma: a study of 33 cases emphasizing its pathologic, immunophenotypic, and biologic uniqueness from juvenile hemangioma. Am J Surg Pathol 28:559-68, 2004

Mac-Moune Lai F, Szeto CC, Choi PCL, Li PKT, Tang NLS, Chow KM, Lui SF, Wong TYH, Ho KKL, To KF. Primary IgA Nephropathy with Low Histological Grade and Disease Progression: Is there a “Point of No Return”? Am J Kidney Dis 39:401-406, 2002