Professor Christopher Lam 林伟基
Adjunct Professor 客座教授



Biography
Professor Lam is at present employed by the Macau University of Science and Technology (MUST), Macao as (1) Chair Professor and Vice Dean of the Faculty of Medicine and (2) Director of Laboratory Medicine at the University Hospital. He took up these appointments upon retiring from The Chinese University of Hong Kong (CUHK) and Prince of Wales Hospital, Hong Kong in 2009. The MUST Faculty of Medicine is a new designation renamed from the previous Faculty of Health Sciences after the university had been granted government approval in March 2019 to establish the first Bachelor of Medicine Bachelor of Surgery (MBBS) program in Macao.



Professor Lam obtained his PhD degree in Immunology from the Southampton General Hospital (UK, 1974), and had worked in the Singapore General Hospital (Singapore, 1975-1979) and the Royal Prince Alfred Hospital (Sydney, Australia, 1991-1993) before and after joining CUHK (1983). His other qualifications include Fellow of the Royal Society of Chemistry (UK, 1985), Fellow of the Academy of Clinical Biochemistry (US, 1989), Honorary Fellow of the Hong Kong College of Pathologists (2004), and Honorary Fellow of the Royal College of Pathologists (UK, 2006). He is also qualified as a Hong Kong Government Listed Practitioner of Chinese Medicine (License Number L07700, since 2001).






Professor Lam is a general clinical biochemist who has published over 600 papers widely in Allergy and Clinical Immunology, Nephrology, Lipidology, Diabetology and Endocrinology, Infectious Diseases, Toxicology, and Chinese Medicine accruing a total citation number of > 18,000 and an h-index of 67. During the SARS epidemic in 2003, Professor Lam developed a postulate that many acute infections and chronic illnesses are in fact communication diseases caused by cytokine and chemokine aberrations resulting in deranged intercellular communication and intracellular signal transduction. This new concept in laboratory medicine has enhanced understanding of the messenger and message pathology of acute and chronic diseases, with clinical applications in patient care using cytokines and chemokines for monitoring and their antibodies (e.g. anti-TNF antibody) for treatment. For this contribution Professor Lam was conferred the IFCC Distinguished Award in Laboratory Medicine and Patient Care in 2008 (IFCC = International Federation of Clinical Biochemistry). His other honors include the APFCB Silver Jubilee Distinguished Medal and Award bestowed in 2006 (APFCB = Asian and Pacific Federation of Clinical Biochemistry).


Professor Lam has been active in local, regional and international services in Clinical Biochemistry. He has served as the Secretary, President, Chief Examiner and Chairman of the Board of Accreditation for the Hong Kong Society of Clinical Chemistry (1987-2001); Secretary and President of APFCB (1994-2004); Executive Board Member (1999-2005) and Vice President cum Chairman of the Awards Committee of IFCC (2009-2011). He has been Visiting Professor in China for (1) the People's Liberation Army General Hospital (301 Hospital) and Postgraduate Medical School (Beijing, since 2000) and (2) Chongqing Medical University (Chongqing, since 2000). His traveling lectureships comprise the Roman Traveling Lectureship of the Australasian Association of Clinical Biochemists (7 state capital cities, 2002), APFCB Traveling Lectureship (8 Asian-Pacific countries, 2006), and IFCC Traveling Lectureship to the EFCC (European Federation of Clinical Chemistry, 2008), for which he presented The Laboratory Medicine of Infectious Diseases and Cybernetics of Cytokines and Chemokines: Pathophysiology and Clinical Applications along a stretch of the River Danube in Croatia, Hungry and the Czech Republic - in exchange for concert tickets for him and his wife in the evenings.


Clinical Biochemistry is real-life biochemistry. Professor Lam has recently undertaken a keen research interest into Largo meaning Front Place or Front Square in Portuguese. In Macao there is a largo for every venue: Largo do Senado (front square of the city council), do Bazar (city market), do Cais (pier), do Alfanega (customs and immigration), do Lilau (of the well of old woman), and even do Matadouro (abattoir), just to name a few. Professor Lam believes that there must have been very substantial real-life activities occurring in these largos advancing culture and civilization. They may be folk-dancing and singing, courting and romance, soccer and other sports, or even quarrels and fights, mostly resulting in a happy ending. Being a quiet and modest person, Professor Lam loves to sit smilingly by a largo and observe the world goes by. He is also keen in enrolling into a tuition course of the Portuguese language for enhancing his appreciation of life-style in the local community.


November 2020

Recent Publications:
1.
Tomlinson B, Chan P, Liu ZM, Lam CWK (Corresponding Author). Statin pharmacology revisited. Cardiovascular Drugs and Therapy 2010 Feb; DOI:10.1007/s10557-020-06051-9.

2.
Tomlinson B (Corresponding Author), Chan P, Liu ZM, Lam CWK (Corresponding Author). Pharmacokinetics of current and emerging treatments of hypercholesterolemia. Expert Opinion on Drug Metabolism & Toxicology; DOI:101080/ 17425255.2020 (Mar). 1749261.

3.
Tomlinson B, Chan P, Lam CWK (Corresponding Author). Postprandial hyperlipidemia as a risk factor in patients with type 2 diabetes. Expert Review of Endocrinology & Metabolism 2020 (Mar); DOI:10.1080/17446651. 1750949.

4.
Hou TH, Sun XY, Zhu J, Hon KL, Jiang PY, Chu IMT, Tsang MSM, Lam CWK, Zeng HS, Wong CK. IL-37 ameliorating allergic inflammation in atopic dermatitis through regulating microbiota and AMPK-mTOR signalling pathway-modulated autophagy mechanism. Frontiers in Immunol 2020 (4). Doi: 10.3389 / fimmu. 2020(4). 00572.

5.
Wu XX, Yue GGL, Dong JR, Lam CWK, Wong CK, Qiu MH, Lau CBS. Actein inhibits tumour growth and metastasis in HER-2 positive breast cancer tumour bearing mice via suppressing AKT/mTOR and Ras/Raf/MAPK signalling pathways. Frontiers in Oncology 2020 (May 27); 10:854. Doi:10.3389/fonc.2020.00854.

6.
Sun XY, Hou TH, Cheung E, Iu TNT, Tam VWH, Chu IMT, Tsang MSM, Chan PKS, Lam CWK, Wong CK. Anti-inflammatory mechanisms of the novel cytokine interleukin-38 in allergic asthma. Cellular and Molecular Immunology 2020 (6); 17:631-646.

7.
Zeng W, Law BYK, Wong VKW, Chan DSB, Mok SWF, Gao JJY, Ho RKY, Liang X, Li JH, Lee MT, Yoon WL, Smolinski MP, Lau JYN, Lam CWK (Corresponding Author), Fok M (Corresponding Author). HM 30181A, a potent P-glycoprotein inhibitor, potentiates absorption and in vivo antitumor efficacy of paclitaxel in an orthotopic brain tumour model. Accepted by Cancer Biology and Medicine 2020 July 28.

8.
Kan LLY, Liu DH, Chan BCL, Tsang MSM, Hou TH, Leung PC, Lam CWK, Wong CK. The flavonoids of Sophora flavescens exert anti-inflammatory activity via promoting autography of Bacillus Calmetic-Guerin-stimulated macrophages. Journal of Leukoc Biol 2020; 108: 1615-29.

9.
Tomlinson B, Chan P, Zhang YZ, Lam CWK (Corresponding Author). Efficacy and safety of add on therapies in patients with hypercholesterolemia undergoing statin therapy. Expert Opinion on Pharmacotherapy 2020 Aug; DOI: 10.1080/14656566.2020.1801638.

10.
Zhang HX, Li Y, Lam CWK, Chen HW, Luo WD, Wang CY, Jiang ZH, Du ZY, Zhang W. Rapid and sensitive determination of four bisphosphonates in rat plasma after MTBSTFA derivatization using lipid chromatography- mass spectrometry. Journal of Pharmaceutical & Biomedical Analysis 190 (August 2020) 113579.

11.
Lin XZ, Li M, Lam CWK (Corresponding Author), Wong BL (Corresponding Author). A meta-analysis of the effects of AIDS education among global students in the 21st century. Chinese Journal of AIDS & STD. Accepted 2020 Aug 20.

12.
Chu M, Tsang MSM, He R, Lam CWK, Quan ZB, Wong CK. The active compounds and therapeutic mechanisms of Pentaherbs formula for oral and topical treatment of atopic dermatitis based on network pharmacology. Plants 2020 (September), 9, 1166; doi:10.3990/plants9091166.

13.
Li RJ, Chen HW, Feng JH, Xiao Y, Zhang HY, Lam CWK, Xiao H. Efficacy of traditional Chinese exercise for symptoms of knee osteoarthritis: A systematic review and meta-analysis of randomized controlled trials. International Journal of Environmental Research and Public Health. Accepted 2020 September 20.