Masashi Yukawa 汤川将之
Assistant Professor 助理教授

masashiyukawa@cuhk.edu.hk


Biography
Professor Yukawa graduated with his PhD (Life Science) from the University of Tokyo in 2013. During his PhD studies, he researched epigenome in embryonic stem cells and preimplantation embryos (with Dr. Fugaku Aoki). After his training in PhD program, he joined Dr. Artem Barski's laboratory at Cincinnati Children's Hospital (United States). He researched epigenome connected to helper T cells. He is an expert of RNA-seq, ChIP-seq, and other epigenome methods as well as molecular and cellular biology’s methods.


Professor Yukawa started new researches in September 2020 as an assistant professor at Department of Chemical Pathology in the Chinese University of Hong Kong. He enjoys both wet lab experiment and computational analysis in research. He is really excited to find scientific discoveries and to contribute to human society in this new research field!







Selected publications:

Akihiko Sakashita, So Maezawa, Kazuki Takahashi, Kris G. Alavattam, Masashi Yukawa, Yueh-Chiang Hu, Shohei Kojima, Nicholas F. Parrish, Artem Barski, Mihaela Pavlicev, Satoshi H. Namekawa. Endogenous retroviruses drive species-specific germline transcriptomes in mammals. Nature Structural & Molecular Biology, 27: 967-977. (2020)

So Maezawa, Akihiko Sakashita, Masashi Yukawa, Xiaoting Chen, Kazuki Takahashi, Kris G. Alavattam, Ippo Nakata, Matthew T. Weirauch, Artem, Barski, Satoshi H. Namekawa. Super-enhancer switching drives a burst in gene expression at the mitosis-to-meiosis transition. Nature Structural & Molecular Biology, 27: 978-988. (2020)

Masashi Yukawa, Sajjeev Jagannathan, Sushmitha Vallabh, Andrey V. Kartashov, Xiaoting Chen, Matthew T. Weirauch, Artem Barski. AP-1 activity induced by co-stimulation is required for chromatin opening during T cell activation. Journal of Experimental Medicine. vol. 217 no. 1. (2020)
---This paper has been recommended in F1000prime as a significant paper.

So Maezawa, Kazuteru Hasegawa, Masashi Yukawa, Naoki Kubo, Akihiko Sakashita, Kris G. Alavattam, Ho-Su Sin, Andrey V. Kartashov, Hiroyuki Sasaki, Artem Barski, and Satoshi H. Namekawa. SCML2 facilitates H3K27me3 to establish bivalent 3 domains in the male germline. Proceedings of the National Academy of Sciences of the United States of America. 8;115(19):4957-4962. (2018).

John B. Harley, Xiaoting Chen, Mario Pujato, Daniel Miller, Avery Maddox, Carmy Forney, Albert F. Magnusen, Arthur Lynch, Kashish Chetal, Masashi Yukawa, Artem Barski, Nathan Salomonis, Kenneth M. Kaufman, Leah C. Kottyan, Matthew T. Weirauch. Transcription factors operate across disease loci with EBNA2 implicated in autoimmunity. Nature Genetics. 50(5):699-707. (2018).

So Maezawa, Masashi Yukawa, Kris G. Alavattam, Artem Barski, and Satoshi H. Namekawa. Dynamic reorganization of open chromatin underlies diverse transcriptomes during spermatogenesis. Nucleic Acids Research. 46(2):593-608. (2018).

So Maezawa, Kazuteru Hasegawa, Masashi Yukawa, Akihiko Sakashita, Kris G. Alavattam, Paul R. Andreassen, Miguel Vidal, Haruhiko Koseki, Artem Barski and Satoshi H. Namekawa. Polycomb directs timely activation of germline genes in spermatogenesis. Genes & Development. 31(16):1693-1703. (2017).

Mariana L. Stevens, Praneet Chaturvedi, Scott A. Rankin, Melissa Macdonald, Sajjeev Jagannathan, Masashi Yukawa, Artem Barski, Aaron M. Zorn. Genomic integration of Wnt/β-catenin and BMP/Smad1 signaling coordinates foregut and hindgut transcriptional program. Development. 144(7):1283-1295. (2017).

Yrina Rochman, Masashi Yukawa, Andrey V. Kartashov, Artem Barski. Functional characterization of human T cell hyporesponsiveness induced by CTLA4-Ig. PLoS One.10(4): e0122198. (2015).

Masashi Yukawa, Tomohiko Akiyama, Vedran Franke, Nathan Mise, Takayuki Isagawa, Yutaka Suzuki, Masataka G. Suzuki, Kristian Vlahovicek, Kuniya Abe, Hiroyuki Aburatani, Fugaku Aoki. Genome-Wide Analysis of the Chromatin Composition of Histone H2A and H3 Variants in Mouse Embryonic Stem Cells. PLoS One. 9(3): e92689. (2014).

Buhe Nashun, Masashi Yukawa, Honglin Liu, Tomohiko Akiyama, Fugaku Aoki. Changes in the nuclear deposition of histone H2A variants during pre-implantation development in mice. Development 137:3785-3794. (2010).

Masashi Yukawa, Shoji Oda, Hiroshi Mitani, Masao Nagata, Fugaku Aoki. Deficiency in the response to DNA double-strand breaks in mouse early preimplantation embryos. Biochemical and Biophysical Research Communications 358: 578-584. (2007).

Mitsuhiro Morita, Nagisa Kozuka, Rurika Itofusa, Masashi Yukawa, Yosihisa Kudo. Autocrine activation of EGF receptor promotes oscillation of glutamate-induced calcium increase in astrocytes cultured in rat cerebral cortex. Journal of Neurochemistry 95: 871-879. (2005).