Chun Kit Choi 蔡俊杰
Research Assistant Professor 研究助理教授

ckkchoi@cuhk.edu.hk


Biography
Kit Choi is currently a Research Assistant Professor in the Department of Chemical Pathology at The Chinese University of Hong Kong (CUHK). Dr. Choi received his Bachelor of Science degree in 2013 and Doctor of Philosophy degree in 2019, both from CUHK. By training, he is a (nano)medicinal chemist and biomedical engineer.


Dr. Choi’s research interest mainly lies on the rational design of novel bionanomaterials (DNA-, plasmonic nanoparticle-, and polymer-based) and bionanotechnologies for understanding fundamental biological processes (e.g., stem cell differentiation and cancer growth) as well as for advancing the healthcare. He anticipates translating his research to clinic, particularly for molecular diagnostics, targeted drug delivery, gene therapy, infection control, and biomedical imaging.







Till now, Dr. Choi has published over 7 first-authored papers in high-impact journals, including Nature Biomedical Engineering, Journal of the American Chemical Society, ACS Nano, Nano Letters, ACS Applied Materials & Interfaces, and Nanoscale. In recognition of his work, Dr. Choi has received a US patent (US10240190B2) and a few external awards, including Poster Presentation Award 2019 (Gordon Research Conference), Best Paper on Materials 2019 (The Hong Kong Institution of Engineers), Top Prize in Student Research Award 2019 (Hong Kong Medical and Healthcare Device Industries Association), and 2021 Young Scientist Award in Life Science (Finalist). In addition, he has served as a reviewer for Micro & Nano Letters.


Selected publications: (A dagger ? in the author list indicates co-first authors.)

Dai, G., Choi, C.K.K., Choi, C.H.J., Fong, W.P. and Ng, D.K.P. (2022) Glutathione-degradable polydopamine nanoparticles as a versatile platform for fabrication of advanced photosensitisers for anticancer therapy. Biomater. Sci. 10, 189-201.

Liu, Y., Choi, C.K.K., Hong, H., Xiao, Y., Kwok, M.L., Liu, H., Tian, X.Y. and Choi, C.H.J. (2021) Dopamine receptor-mediated binding and cellular uptake of polydopamine-coated nanoparticles. ACS Nano 15, 13871-13890.

Dai, G.,? Choi, C.K.K.,? Zhou, Y., Bai, Q., Xiao, Y., Yang, C., Choi, C.H.J. and Ng, D.K.P. (2021) Immobilizing hairpin DNA-conjugated distyryl boron dipyrromethene on gold@polydopamine core-shell nanorods for microRNA detection and microRNA-mediated photodynamic therapy. Nanoscale 13, 6499-6512.

Choi, C.K.K.,? Chiu, Y.T.E.,? Zhuo, X.,? Liu, Y., Pak, C.Y., Liu, X., Tse, Y.-L. S., Wang, J. and Choi, C.H.J. (2019) Dopamine-mediated assembly of citrate-capped plasmonic nanoparticles into stable core–shell nanoworms for intracellular applications. ACS Nano 13, 5864-5884.

Chen, Z.,? Choi, C.K.K.? and Wang, Q. (2018) Origin of the plasmonic chirality of gold nanorod trimers templated by DNA origami. ACS Appl. Mater. Interfaces 10, 26835-26840.

Choi, C.K.K., Zhang, L. and Choi, C.H.J. (2018) Efficient siRNA delivery with non-cationic carriers. Nat. Biomed. Eng. 2, 275-276.

Choi, C.K.K.,? Zhuo, X.,? Chiu, Y.T.E, Yang, H., Wang, J. and Choi, C.H.J. (2017) Polydopamine-based concentric nanoshells with programmable architectures and plasmonic properties. Nanoscale 9, 16968-16980.

Choi, C.K.K., Xu, Y.J., Wang, B., Zhu, M., Zhang, L. and Bian, L. (2015) Substrate coupling strength of integrin-binding ligands modulates adhesion, spreading, and differentiation of human mesenchymal stem cells. Nano Lett. 15, 6592-6600.

Choi, C.K.K., Li, J., Wei, K., Xu, Y.J., Ho, L.W., Zhu, M., To, K.K., Choi, C.H.J. and Bian, L. (2015) A gold@polydopamine core-shell nanoprobe for long-term intracellular detection of microRNAs in differentiating stem cells. J. Am. Chem. Soc. 137, 7337-7346.