Peiyong Jiang 江培勇
Associate Professor 副教授

jiangpeiyong@cuhk.edu.hk


Biography
Peiyong Jiang is currently an associate professor and a bioinformatician at the Department of Chemical Pathology, The Chinese University of Hong Kong. He serves as Director of Biomedical Computing Centre at the Li Ka Shing Institute of Health Sciences (LiHS). He received his bachelor's degree in bioengineering from Huzhou Teachers College in 2006. During that time, he was trained in biology, biochemistry, genetics, biostatistics and programming languages. Afterward, he received his master's degree in crop genetics and breeding from Huazhong Agricultural University in 2009. During the time of pursuing a master's degree, he was mainly trained in advanced genetics, statistics, and bioinformatics. His research work involved the plant microRNA prediction in silico, particularly using machine learning algorithm to explore Next Generation Sequencing (NGS) data. Thereafter, he received his Ph.D. in Chemical Pathology from The Chinese University of Hong Kong in 2012 and had postdoctoral training at the Department of Chemical Pathology, The Chinese University of Hong Kong from 2012 to 2015. Since he joined the department, he has been working on bioinformatics. With a multidisciplinary background of genomics, bioinformatics, computational biology, and statistics, he has a long-standing research interest in NGS-based bioinformatics data analysis as well as its clinical applications such as noninvasive prenatal testing and cancer detection.








He was named the “Top 20 Translational Researchers of 2019” by the world-renowned scientific journal Nature Biotechnology in 2020. He has recently been elected a senior member of the National Academy of Inventors (NAI) (the first scholar from a Hong Kong institution to receive this senior membership).

Specialized Research Area(s):
1. Developing mathematical algorithms and bioinformatics software for the Next Generation Sequencing (NGS) data analysis
2. Developing bioinformatics algorithms for the noninvasive prenatal testing and noninvasive cancer detection

3. Field-Programmable Gate Array (FPGA) based computing acceleration for NGS-based big data analysis

Bioinformatics Resources:
FetalQuant^SD - http://www.cuhk.edu.hk/med/cpy/Research/FetalQuantSD

Selected publications:



Tse OYO*, Jiang P*, Cheng SH*, Peng W, Shang H, Wong J, Chan SL, Poon LCY, Leung TY, Chan KCA, Chiu RWK, Lo YMD. Genome-wide detection of cytosine methylation by single molecule real-time sequencing. Proc Natl Acad Sci USA 2021; 118:e2019768118. (*contributed equally to this work)

Jiang P*, Sun K*, Peng W*, Cheng SH, Ni M, Yeung PC, Heung MMS, Xie T, Shang H, Zhou Z, Chan RWY, Wong J, Wong VWS, Poon LC, Leung TY, Lam WKJ, Chan JYK, Chan HLY, Chan KCA, Chiu RWK, Lo YMD. Plasma DNA End-Motif Profiling as a Fragmentomic Marker in Cancer, Pregnancy, and Transplantation. Cancer Discov 2020;10:664-673. (*contributed equally to this work)

Sin STK, Jiang P, Deng J, Ji L, Cheng SH, Dutta A, Leung TY, Chan KCA, Chiu RWK, Lo YMD. Identification and characterization of extrachromosomal circular DNA in maternal plasma. Proc Natl Acad Sci USA 2020;117s:1658-1665.

Ma ML*, Zhang H*, Jiang P*, Sin STK, Lam WKJ, Cheng SH, Lee WS, Gai W, Tse OYO, Peng W, Wong J, Raghupathy R, Wong RSM, Sahota D, Leung TY, Chan KCA, Chiu RWK, Lo YMD. Topologic Analysis of Plasma Mitochondrial DNA Reveals the Coexistence of Both Linear and Circular Molecules. Clin Chem 2019;65:1161-1170. (*contributed equally to this work)

Lam WKJ*, Jiang P*, Chan KCA*, Peng W, Shang H, Heung MMS, Cheng SH, Zhang H, Tse OYO, Raghupathy R, Ma BBY, Hui EP, Chan ATC, Woo JKS, Chiu RWK, Lo YMD. Methylation analysis of plasma DNA informs etiologies of Epstein-Barr virus-associated diseases. Nat Commun 2019;10:3256. (*contributed equally to this work)

Gabbett MT, Laporte J, Sekar R, Nandini A, McGrath P, Sapkota Y, Jiang P, Zhang H, Burgess T, Montgomery GW, Chiu RWK, Fisk NM. Molecular Support for Heterogonesis Resulting in Sesquizygotic Twinning. N Engl J Med. 2019;380:842-849.

Sun K, Jiang P, Cheng SH, Cheng THT, Wong J, Wong VWS, Ng SSM, Ma BBY, Leung TY, Chan SL, Mok TSK, Lai PBS, Chan HLY, Sun H, Chan KCA, Chiu RWK, Lo YMD. Orientation-aware plasma cell-free DNA fragmentation analysis in open chromatin regions informs tissue of origin. Genome Res 2019;29:418-427.

Jiang P*, Sun K*, Tong YK, Cheng SH, Cheng THT, Heung MMS, Wong J, Wong VWS, Chan HLY, Chan KCA, Lo YMD, Chiu RWK. Preferred end coordinates and somatic variants as signatures of circulating tumor DNA associated with hepatocellular carcinoma. Proc Natl Acad Sci USA 2018;115:E10925-E10933. (*contributed equally to this work)

Lam WKJ*, Jiang P*, Chan KCA*, Cheng SH, Zhang H, Peng W, Tse OYO, Tong YK, Gai W, Zee BCY, Ma BBY, Hui EP, Chan ATC, Woo JKS, Chiu RWK, Lo YMD. Sequencing-based counting and size profiling of plasma Epstein-Barr virus DNA enhance population screening of nasopharyngeal carcinoma. Proc Natl Acad Sci USA 2018;115:E5115-E5124. (*contributed equally to this work)

Yu SC*, Jiang P*, Chan KCA*, Faas BH, Choy KW, Leung WC, Leung TY, Lo YMD, Chiu RWK. Combined Count- and Size-Based Analysis of Maternal Plasma DNA for Noninvasive Prenatal Detection of Fetal Subchromosomal Aberrations Facilitates Elucidation of the Fetal and/or Maternal Origin of the Aberrations. Clin Chem 2017;63:495-502. (*contributed equally to this work)

Hui WW, Jiang P, Tong YK, Lee WS, Cheng YK, New MI, Kadir RA, Chan KC, Leung TY, Lo YMD, Chiu RWK. Universal Haplotype-Based Noninvasive Prenatal Testing for Single Gene Diseases. Clin Chem 2017;63:513-524.

Arram J, Kaplan T, Luk W, Jiang P. Leveraging FPGAs for Accelerating Short Read Alignment. IEEE/ACM Trans Comput Biol Bioinform2017;14:668-677.

Jiang P, Lo YMD. The Long and Short of Circulating Cell-Free DNA and the Ins and Outs of Molecular Diagnostics. Trends Genet 2016;32:360-371.

Chan KC*, Jiang P*, Sun K*, Cheng YK, Tong YK, Cheng SH, Wong AI, Hudecova I, Leung TY, Chiu RWK, Lo YMD. Second generation noninvasive fetal genome analysis reveals de novo mutations, single-base parental inheritance, and preferred DNA ends. Proc Natl Acad Sci USA 2016;113:E8159-E8168. (*contributed equally to this work)

Jiang P*, Chan CW*, Chan KCA*, Cheng SH, Wong J, Wong VW, Wong GL, Chan SL, Mok TS, Chan HL, Lai PB, Chiu RWK, Lo YMD. Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients.Proc Natl Acad Sci USA2015;112:E1317-25. (*contributed equally to this work)

Sun K*,Jiang P*, Chan KCA*, Wong J, Cheng YK, Liang RH, Chan WK, Ma ES, Chan SL, Cheng SH, Chan RW, Tong YK, Ng SS, Wong RS, Hui DS, Leung TN, Leung TY, Lai PB, Chiu RWK, Lo YMD. Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments.Proc Natl Acad Sci USA2015;112:E5503-12. (*contributed equally to this work)

Jiang P, Sun K, Lun FM, Guo AM, Wang H, Chan KCA, Chiu RWK, Lo YMD, Sun H. Methy-Pipe: an integrated bioinformatics pipeline for whole genome bisulfite sequencing data analysis.PLoS One2014;9:e100360.

Chan KCA*,Jiang P*, Chan CW*, Sun K, Wong J, Hui EP, Chan SL, Chan WC, Hui DS, Ng SS, Chan HL, Wong CS, Ma BB, Chan AT, Lai PB, Sun H, Chiu RWK, Lo YMD. Noninvasive detection of cancer-associated genome-wide hypomethylation and copy number aberrations by plasma DNA bisulfite sequencing.Proc Natl Acad Sci USA2013;110:18761-8. (*contributed equally to this work)

Jiang P, Chan KCA, Liao GJ, Zheng YW, Leung TY, Chiu RWK, Lo YMD, Sun H. FetalQuant: deducing fractional fetal DNA concentration from massively parallel sequencing of DNA in maternal plasma.Bioinformatics2012;28:2883-90.

Tsui NB,Jiang P, Wong YF, Leung TY, Chan KCA, Chiu RWK, Sun H, Lo YMD. Maternal plasma RNA sequencing for genome-wide transcriptomic profiling and identification of pregnancy-associated transcripts.Clin Chem2014;60:954-62.

Sun K, Chen XN,Jiang P, Song XF, Wang HT, Sun H. iSeeRNA: identification of long intergenic non-coding RNA transcripts from transcriptome sequencing data.BMC Genomics2013;14 Suppl 2:S7.

Chan KCA,Jiang P, Zheng YWL, Liao GJW, Sun H, Wong J, Siu SSN, Chan WC, Chan SL, Chan ATC, Lai PBS, Chiu RWK, Lo YMD. Cancer genome scanning in plasma: detection of tumor-associated copy number aberrations, single-nucleotide variants, and tumoral heterogeneity by massively parallel sequencing.Clin Chem2013;59:211-224.

Chan RWY,Jiang P, Peng X, Tam LS, Liao GJW, Li EKM, Wong PCH, Sun H, Chan KCA, Chiu RWK, Lo YMD. Plasma DNA aberrations in systemic lupus erythematosus revealed by genomic and methylomic sequencing.Proc Natl Acad Sci USA2014;111:E5302-E5311.

Zhao Y, Yang Y, Trovik J, Sun K, Zhou L,Jiang P, Lau TS, Hoivik EA, Salvesen HB, Sun H, Wang H. A novel wnt regulatory axis in endometrioid endometrial cancer.Cancer Res2014;74:5103-17.

Yu SCY*, Chan KCA*, Zheng YWL*,Jiang P, Liao GJW, Sun H, Akolekar R, Leung TY, Go ATJI, van Vugt JMG, Minekawa R, Oudejans CBM, Nicolaides KH, Chiu RWK, Lo YMD. Size-based molecular diagnostics using plasma DNA for noninvasive prenatal testing.Proc Natl Acad Sci USA2014;111:8583-8588. (*contributed equally to this work)

New MI, Tong YK*, Yuen T*,Jiang P, Pina C, Chan KCA, Khattab A, Liao GJW, Yau M, Kim SM, Chiu RWK, Sun L, Zaidi M, Lo YMD. Noninvasive prenatal diagnosis of congenital adrenal hyperplasia using cell-free fetal DNA in maternal plasma.J Clin Endocrinol Metab2014;99:E1022-E1030. (*contributed equally to this work)

Wang L, Zhou L,Jiang P, Lu L, Chen X, Lan H, Guttridge DC, Sun H, Wang H. Loss of miR-29 in myoblasts contributes to dystrophic muscle pathogenesis.Mol Ther2012;1222-33.

Chan LL,Jiang P. Bioinformatics analysis of circulating cell-free DNA sequencing data.Clin Biochem2015;48:962-75.