Hao Sun 孙昊
Professor 教授

haosun@cuhk.edu.hk


Biography
Professor Hao Sun is currently a professor and a bioinformatics specialist in the Department of Chemical Pathology. He received his Ph.D. in the field of Environmental Chemistry from Nanjing University, China in 1998 and a M.S. degree in Computer Science from the University of Akron, USA in 2002. Before he joined The Chinese University of Hong Kong in 2009, he worked as a Co-Director of the Bioinformatics Core Facility in Wistar Institute at Philadelphia, USA during 2008 to 2009 and as a Research Scientist/Adjunct Assistant Professor in the Department of Molecular Virology, Immunology and Medical Genetics, College of Medicine and Public Health, at the Ohio State University, USA from 2001 to 2008.







Research Interests:
Professor Sun’s research interests focus on:
(i)
Understanding the fundamental aspects of transcriptional regulation of both coding and noncoding genes using integrative approaches;
(ii)
Developing bioinformatics software for Next Generation Sequencing (NGS) data analysis;
(iii)
Developing of new computational algorithms and tools for identifying novel biomarkers, particularly for non-invasive disease diagnosis using high-throughput DNA sequencing.




His research is computationally driven and interdisciplinary in nature with a complement of collaborative experimental investigation with bench scientists.

Selected Grants:

Genome-wide computational identification and CRISPR screen of key Transcription Factors (TFs) and TF hotspots governing muscle satellite cell lineage progression (14116918). Hong Kong SAR University Grants Committee, Research Grants Council, General Research Fund (GRF). 01/01/2019-31/12/2021, HK$ 1,136,632

Large scale interaction analysis of RNA binding proteins/LncRNAs to identify lncRNA nuclear localization mechanisms (14120619). Hong Kong SAR University Grants Committee, Research Grants Council, General Research Fund (GRF). 01/01/2020-31/12/2022 HK$ 1,115,8175

Study on the Mechanism Underlying BMAL1/CLOCK-mediated Regulation of Human Stem Cell Homeostasis and Aging (N_CUHK413/18). National Natural Science Foundation of China (NSFC) / Research Grants Council (RGC) Joint Research Scheme 2019/19. 01/01/2019-31/12/2022 HK$ 1,166,714

Identification and functional characterization of super enhancer associated RNAs (seRNAs) in skeletal myogenesis using integrated genomic (14102315) Hong Kong SAR University Grants Committee, Research Grants Council, General Research Fund (GRF) 01/01/2016-31/12/2018, Funding Amount: HK$ 1,228,445




Selected Publications (* corresponding author):

Zhou J, So KK, Li Y, Li Y, Yuan J, Ding Y, Chen F, Huang Y, Liu J, Lee W, Li G, Ju Z, Sun H*, Wang H*. Elevated H3K27ac in aged skeletal muscle leads to increase of extracellular matrix and fibrogenic conversion of muscle satellite cells. Aging Cell. 2019. Jul 20:e12996. doi: 10.1111/acel.12996.

Chen F, Zhou J, Li Y, Zhao Y, Yuan J, Cao Y, Wang L, Zhang Z, Zhang B, Wang CC, Cheung TH, Wu Z, Wong CC, Sun H*,?Wang H*. YY1 regulates skeletal muscle regeneration through controlling metabolic reprogramming of satellite cells.?EMBO J.?2019 May 15;38(10).

Yuan J, Zhou J, Wang H*, Sun H*. SKmDB: an integrated database of next generation sequencing information in skeletal muscle. Bioinformatics. 2018 August 25. doi: 10.1093/bioinformatics/bty705.

Kun Sun*, Jiguang Wang, Huating Wang, Hao Sun*. GeneCT: a generalizable concerous status and tissue origin classifier for pan-cancer biopsies. Bioinformatics, 2018 Dec 1;34(23):4129-4130. doi: 10.1093/bioinformatics/bty524

Jiajian Zhou, Yile Huang, Yingzhe Ding, Jie, Yuan, Huating Wang*, Hao Sun*. (2018). lncFunTK: A toolkit for functional annotation of long noncoding RNAs. Bioinformatics, bty339, https://doi.org/10.1093/bioinformatics/bty339.

Yao M, Zhou X, Zhou J, Gong S, Hu G, Li J, Huang K, Lai P, Shi G, Hutchins AP, Sun H, Wang H and Yao H. (2018). PCGF5 is required for neural differentiation of embryonic stem cells. Nat Commun. 2018 May 15;9(1):1463.

Bao X, Guo X, Yin M, Tariq M, Lai Y, Kanwal S, Zhou J, Li N, Lv Y, Pulido-Quetglas C, Wang X, Ji L, Khan MJ, Zhu X, Luo Z, Shao C, Lim DH, Liu X, Li N, Wang W, He M, Liu YL, Ward C, Wang T, Zhang G, Wang D, Yang J, Chen Y, Zhang C, Jauch R, Yang YG, Wang Y, Qin B, Anko ML, Hutchins AP, Sun H, Wang H, Fu XD, Zhang B, Esteban MA. Capturing the interactome of newly transcribed RNA. (2018) Nature Methods 2018 Mar; 15(3):213-220. doi: 10.1038/nmeth.4595.

Kun Sun, Fiona M.F. Lun, Tak Y.Leung, Rossa W.K. Chiu, Y.M.Dennis Lo, Hao Sun*. Noninvasive reconstruction of placental methylome from maternal plasma DNA: Potential for prenatal testing and monitoring. Prenat Diagn. 2018 Feb;38(3):196-203. doi: 10.1002/pd.5214.

Sun K., Lun F.M.F., Jiang P., Sun H*. (2017). BSviewer: a genotype-preserving, nucleotide-level visualizer for bisulfite sequencing data. Bioinformatics 2017 Nov 1; 33(21):3495-3496.

Peng X., So K.K., He L., Zhao Y., Zhou J., Li Y., Yao M., Xu B., Zhang S., Yao H., Hu P., Sun H.*, Wang H*. (2017). MyoD- and FoxO3-mediated hotspot interaction orchestrates super-enhancer activity during myogenic differentiation. Nucleic Acids Res. 2017 Jun 1.

Zhou J., Zhang S., Wang H.*, Sun H.* (2017). LncFunNet: an integrated computational framework for identification of functional long noncoding RNAs in mouse skeletal muscle cells. Nucleic Acid Research 2017 Apr 4.

Sun K., Wang H.*, Sun H.* (2017). mTFkb: a knowledgebase for fundamental annotation of mouse transcription factors. Sci Rep. 2017 Jun 8;7(1):3022.

Stunnenberg HG; International Human Epigenome Consortium, Hirst M. (2016). The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery. Cell. 2016 Dec 15;167(7):1897. doi: 10.1016/j.cell.2016.12.002. (as co-author listed in International Human Epigenome Consortium).

Zhou L, Sun K, Zhao Y, Zhang S, Wang X, Li Y, Lu L, Chen X, Chen F, Bao X, Zhu X, Wang ZL, Tang LY, Esteban MA, Wang CC, Jauch R, Sun H*, and Wang H*. Linc-YY1 promotes myogenic differentiation and muscle regeneration through an interaction with the transcription factor YY1. Nature Communications. 2015 6:10026 | DOI: 10.1038/ncomms10026.

Liu L, Xu Y, He M, Zhang M, Cui F, Lu L, Yao M, Tian W, Benda C, Zhuang Q, Huang Z, Li W, Li X, Zhao P, Fan W, Luo Z, Li Y, Wu Y, Hutchins AP, Wang D, Tse HF, Schambach A, Frampton J, Qin B, Bao X, Yao H, Zhang B, Sun H, Pei D, Wang H, Wang J, Esteban MA. (2014). Transcriptional Pause Release is a Rate-limiting Step for Somatic Cell Reprogramming. Cell Stem Cell. Nov 6; 15(5):574-88. DOI: 10.1016/j.stem.2014.09.018.

Sun, K., Yuen, Y. P., Wang, H. and Sun, H.*, (2014). Online Diagnosis System: A webserver for analysis of Sanger sequencing-based genetic testing data. Methods 2014, 69(3):230-236.

Sun, K., Zhao, Y., Wang, H., and Sun, H*. (2014) Sebnif: An Integrated Bioinformatics Pipeline for the Identification of Novel Large Intergenic Noncoding RNAs (lincRNAs) -Application in Human Skeletal Muscle Cells, PLoS One , 9(1):e84500.

Sun, K., Chen, X., Jiang, P., Song, X., Wang, H., and Sun, H.* (2013) iSeeRNA: identification of long intergenic non-coding RNA transcripts from transcriptome sequencing data, BMC Genomics 14 Suppl 2, S7.