Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 梁廷勋教授 (儿科学系) |
| 伍百祥教授 (儿科学系) |
| 霍泰辉教授 (儿科学系) |
| 林鸿生教授 (儿科学系) |
| 洪之韵教授 (化学病理学系) |
| 韩锦伦教授 (儿科学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1111/j.1399-3038.2010.01022.x |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/14WOS source URL
其它资讯
摘要The incidence of eczema has been increasing in developed countries. Environmental and hygiene factors have been incriminated. Although air and food pollution with heavy metals have been considered as possible culprits, these factors have never been investigated in Hong Kong. To evaluate if quality of life and eczema severity are associated with abnormal serum levels of six common heavy metals, namely, cadmium, lead, mercury, selenium, copper and zinc. Serum or whole blood was taken for measurement of six heavy metals from patients referred to the pediatric dermatology clinic. Eczema severity (SCORAD and NESS) and quality of life (CDLQI) were recorded. A total of 110 patients with eczema and 41 patients with miscellaneous skin conditions were recruited. Serum levels of the six heavy metals were generally within the upper limits of local reference ranges. Zinc levels were below the lower reference limit of 9.4 mu m in 66 patients with eczema (60%) and 22 non-eczema patients (53%). Forty-four patients with eczema (40%) and 24 (58%) in non-eczema group had low copper levels. In eczema patients, lead levels were generally within normal limits but their levels were positively correlated with poor quality of life (CDLQI: r = 0.22 and p < 0.05), disease severity (objective SCORAD: r = 0.33 and p < 0.005; NESS: 0.20, p < 0.05), eosinophil count and log-transformed IgE. Copper/zinc ratio also correlated with NESS and CDLQI and was generally higher than non-eczema skin diseases. Our findings help reassure parents that levels of heavy metals generally do not exceed the local reference ranges for toxicity. However, lead levels have significant correlations with disease severity, quality of life and atopy. Low zinc and copper levels are commonly found in pediatric skin diseases and their significance needs to be determined.
着者Hon KLE, Wang SS, Hung ECW, Lam HS, Lui HHK, Chow CM, Ching GKW, Fok TF, Ng PC, Leung TF
期刊名称Pediatric Allergy and Immunology
出版年份2010
月份8
日期1
卷号21
期次5
出版社WILEY-BLACKWELL
页次831 - 836
国际标準期刊号0905-6157
电子国际标準期刊号1399-3038
语言英式英语
关键词atopic dermatitis; cadmium; copper; lead; mercury; NESS; quality of life; SCORAD; selenium; zinc
Web of Science 学科类别Allergy; ALLERGY; Immunology; IMMUNOLOGY; Pediatrics; PEDIATRICS
