Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 邓亮生教授 (化学病理学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1007/s00774-008-0020-z |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/13WOS source URL
其它资讯
摘要Osteoporosis is a common disease characterized by compromised bone strength predisposing a person to an increased risk of osteoporotic fracture (OF). Recently, extensive efforts have been made to identify candidate genes underlying osteoporosis by the use of surrogate phenotypes, such as bone mineral density (BMD) and bone geometry. Among them, BMD is a suitable choice if we aim to classify the role of biological pathways for bone strength and to understand the bone conditions in the development of osteoporosis. However, evidences show that the genetic correlation between BMD and OF is very limited. In this review, we are mainly concerned with an important issue, i.e., phenotype choice in osteoporosis genetic research. For clarity, we address this issue with several arguments, and comments are made on most representative literature.
着者Chen Y, Shen H, Yang F, Liu PY, Tang N, Recker RR, Deng HW
期刊名称Journal of Bone and Mineral Metabolism
出版年份2009
月份3
日期1
卷号27
期次2
出版社Springer Verlag (Germany)
页次121 - 126
国际标準期刊号0914-8779
电子国际标準期刊号1435-5604
语言英式英语
关键词Genetic study; Osteoporosis; Risk factor
Web of Science 学科类别Endocrinology & Metabolism; ENDOCRINOLOGY & METABOLISM; Medicine, Research & Experimental; MEDICINE, RESEARCH & EXPERIMENTAL; Research & Experimental Medicine
