Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 梁廷勋教授 (儿科学系) |
| 陈重娥教授 (内科及药物治疗学系) |
| 黄永坚教授 (儿科学系) |
| 林伟基教授 (化学病理学系) |
| 何宗信教授 (化学病理学系) |
| 蔡继洲博士 (那打素护理学院) |
| 江碧珊教授 (内科及药物治疗学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1159/000189196 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/30WOS source URL
其它资讯
摘要Background: Despite parallel increases in asthma and obesity prevalence, there is little data on obesity as a risk factor for atopy. The latter is an important phenotype in asthmatic patients. This study investigates the association between asthma traits, atopy and obesity-related markers in Chinese adolescents. Methods: 486 schoolchildren were recruited among participants of our population-based study on the epidemiology of obesity, and their allergy status was ascertained using a standardized questionnaire. Subjects' anthropometry was recorded on-site, and fasting blood was collected for allergen-specific immunoglobulin E (IgE), lipids and systemic inflammatory biomarkers. Results: 98 (20.2%) subjects were classified as overweight or obese. Obesity status was not associated with asthma, allergic rhinitis or eczema (p > 0.25). Atopy was not associated with age-adjusted body mass index (BMI) or waist circumference. Atopy and presence of allergen-specific IgE did not differ between overweight or obese children and those with normal BMI (p > 0.25), although subgroup analysis suggested that cockroach sensitization was more common among males who were obese or overweight (p = 0.045). White cell count (WCC) was higher among atopic than nonatopic children (mean values 6.5 X 10(9) /l vs. 6.2 X 10(9) /l, p = 0.006). Logistic regression revealed WCC to be the only risk factor for atopy (OR 18.97, p = 0.004). Conclusions: Obesity is not associated with asthma or atopy in Chinese children. High WCC is an important risk factor for atopy in both males and females. Gender does not exert any consistent effect on the association between obesity and allergen sensitization in children. Copyright (C) 2009 S. Karger AG, Basel
着者Leung TF, Kong APS, Chan IHS, Choi KC, Ho CS, Chan MHM, So WY, Lam CWK, Wong GWK, Chan JCN
期刊名称INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
出版年份2009
月份1
日期1
卷号149
期次2
出版社KARGER
页次133 - 140
国际标準期刊号1018-2438
电子国际标準期刊号1423-0097
语言英式英语
关键词Asthma; Atopy, child; Immunoglobulin E; Obesity, child
Web of Science 学科类别Allergy; ALLERGY; Immunology; IMMUNOLOGY
