Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 吴浩强教授 (病理解剖及细胞学系) |
| 黄家星教授 (内科及药物治疗学系) |
| 邓亮生教授 (化学病理学系) |
| 彭智培教授 (眼科及视觉科学学系) |
| 莫仲棠教授 (内科及药物治疗学系) |
| 赵凤琴教授 (精神科学系) |
| 郭志锐教授 (内科及药物治疗学系) |
| 林翠华教授 (精神科学系) |
| 包立怡教授 (药剂学院) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1159/000095246 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/33WOS source URL
其它资讯
摘要Background/Aims: The apolipoprotein E (ApoE) exon 4 polymorphism has been associated with vascular dementia (VaD) risk. Since not all studies confirm this finding, we explored this association in a case-control study. Methods: We genotyped ApoE in 144 VaD patients and 251 controls. Results: VaD patients were more likely than controls to have ApoE epsilon 3/epsilon 4 or epsilon 4/epsilon 4 genotypes: 23.6% versus 15.1%, odds ratio ( OR) = 1.7, p = 0.036. This association remained significant after adjustment for age, sex, hypertension and diabetes by multiple logistic regression: OR = 1.9, p = 0.030. The association of epsilon 3/epsilon 4 or epsilon 4/epsilon 4 genotypes with VaD was strong among people with hypertension ( OR = 2.9, p = 0.007) or diabetes ( OR = 6.5, p = 0.011). The association was absent among people without hypertension ( OR = 1.1, p = 0.79) or diabetes ( OR = 1.3, p = 0.43). Conclusion: This interaction with hypertension and diabetes should be examined in other studies to confirm or refute this observation. Copyright (C) 2006 S. Karger AG, Basel.
着者Baum L, Lam LCW, Kwok T, Lee J, Chiu HFK, Mok VCT, Wong A, Chen XY, Cheung WS, Pang CP, Ma SL, Tang NLS, Wong KS
期刊名称Dementia and Geriatric Cognitive Disorders
出版年份2006
月份1
日期1
卷号22
期次4
出版社KARGER
页次301 - 305
国际标準期刊号1420-8008
电子国际标準期刊号1421-9824
语言英式英语
关键词apolipoprotein E; apolipoprotein E, allele; apolipoprotein E, genotype; dementia, vascular; diabetes; hypertension; polymorphism
Web of Science 学科类别Clinical Neurology; CLINICAL NEUROLOGY; Geriatrics & Gerontology; GERIATRICS & GERONTOLOGY; Neurosciences & Neurology; Psychiatry; PSYCHIATRY, SCI
