Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 杜家辉教授 (病理解剖及细胞学系) |
| 邓亮生教授 (化学病理学系) |
| 罗?业教授 (病理解剖及细胞学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1002/path.1897 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/19WOS source URL
其它资讯
摘要The previous epidemic of severe acute respiratory syndrome (SARS) has ended. However, many questions concerning how the aetiological agent, the novel SARS coronavirus (CoV), causes illness in humans remain unanswered. The pathology of fatal cases of SARS is dominated by diffuse alveolar damage. Specific histological changes are not detected in other organs. These contrast remarkably with the clinical picture, in which there are apparent manifestations in multiple organs. Both pathogen and host factors are important in the pathogenesis of SARS. The choice of specific receptors and the unique genome of the SARS-CoV are important elements in understanding the biology of the pathogen. For the host cells, the outcome of SARS-CoV infection, whether there are cytopathic effects or not, depends on the cell types that are infected. At the whole-body level, immune-mediated damage, due to activation of cytokines and/or chemokines and, perhaps, autoimmunity, may play key roles in the clinical and pathological features of SARS. Continued research is still required to determine the pathogenetic mechanisms involved and to combat this new emerging human infectious disease. Copyright (c) 2006 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
着者Lo AWI, Tang NLS, To KF
期刊名称Journal of Pathology
出版年份2006
月份1
日期1
卷号208
期次2
出版社JOHN WILEY & SONS LTD
页次142 - 151
国际标準期刊号0022-3417
电子国际标準期刊号1096-9896
语言英式英语
关键词chemokines; coronavirus; cytokines; pathogenesis; SARS
Web of Science 学科类别Oncology; ONCOLOGY; Pathology; PATHOLOGY
