Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 李锦滔教授 |
| 司徒卓俊教授 (内科及药物治疗学系) |
| 李锦滔教授 |
| 谭丽珊教授 (内科及药物治疗学系) |
| 李国铭教授 |
| 黎永祥教授 (病理解剖及细胞学系) |
| 陈颖欣博士 (化学病理学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1191/0961203306lu2287oa |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/16WOS source URL
其它资讯
摘要Mononuclear cells play a cardinal role in the pathogenesis of systemic lupus erythematosus (SLE). A high urine cytology score has been reported to be associated with lupus nephritis in relapse. The objective of this study was to examine the urinary mononuclear cell population of patients with lupus nephritis, and explore its correlation with lupus disease activity. We studied 12 patients with active lupus nephritis, 17 patients with lupus nephritis in remission, 12 SLE patients with no history of renal disease and 13 healthy subjects. Clinical disease activity was quantified by the SLE Disease Activity Index (SLEDAI). Mononuclear cell species in the urinary sediment were examined by immunocytochemistry. Patients with active lupus nephritis had significantly more mononuclear cells in the urinary sediment. The number of CD3+ cell was significantly elevated in the active lupus nephritis than the others (P < 0.001), while there was no significant difference in the number of CD20+ and CD56+ cell among patient groups. The total urinary mononuclear cell correlated significantly with the overall SLEDAI score (r = 0.58, P < 0.001) as well as the renal score (r = 0.57, P < 0.001). The number of urinary CD3+, but not CD20+ or CD56+, cell significantly correlated with the overall SLEDAI score (r = 0.46, P = 0.003) as well as the renal score (r = 0.40, p = 0.011). In nine patients with renal biopsy, the histological activity index correlated with the total urinary mononuclear cell (r = 0.75, P = 0.02), CD3+ (r = 0.69, P = 0.04) and CD20+ cell (r = 0.69, P = 0.04). We conclude that urinary mononuclear cell was markedly elevated in patients with active lupus, and the urinary mononuclear cell count correlated significantly with the SLEDAI score and histological activity. CD3+ and CD20+ cells are the major component of urinary mononuclear cell in SLE patients and their number correlates with lupus disease activity.
着者Chan RWY, Lai FM, Li EKM, Tam LS, Chung KY, Chow KM, Li PKT, Szeto CC
期刊名称Lupus
出版年份2006
月份1
日期1
卷号15
期次5
出版社HODDER ARNOLD, HODDER HEADLINE PLC
页次262 - 267
国际标準期刊号0961-2033
电子国际标準期刊号1477-0962
语言英式英语
关键词lupus nephritis; lymphocyte; NK cell; urinalysis
Web of Science 学科类别Rheumatology; RHEUMATOLOGY
