BRE enhances in vivo growth of tumor cells
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香港中文大学研究人员 ( 现职)


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摘要Human BRE, a death receptor-associating intracellular protein, attenuates apoptotic response of human and mouse tumor cell lines to death receptor stimuli in vitro. In this report, we addressed whether the in vitro antiapoptotic effect of BRE could impact on tumor growth in vivo. We have shown that the mouse Lewis lung carcinoma D122 stable transfectants of human BRE expression vector developed into local tumor significantly faster than the stable transfectants of empty vector and parental D122, in both the syngeneic C57BL/6 host and nude mice. In vitro growth of the BRE stable transfectants was, however, not accelerated. No significant difference in metastasis between the transfectants and the parental D122 was detected. Thus, overexpression of BRE promotes local tumor growth but not metastasis. We conclude that the enhanced tumor growth is more likely due to the antiapoptotic activity of BRE than any direct effect of the protein on cell proliferation. (C) 2004 Published by Elsevier Inc.

着者Chan BCL, Li Q, Chow SKY, Ching AKK, Liew CT, Lim PL, Lee KKH, Chan JYH, Chui YL
期刊名称Biochemical and Biophysical Research Communications
出版年份2005
月份1
日期14
卷号326
期次2
出版社ACADEMIC PRESS INC ELSEVIER SCIENCE
页次268 - 273
国际标準期刊号0006-291X
电子国际标準期刊号1090-2104
语言英式英语

关键词antiapoptotic protein; apoptosis; BRE; cancer; D122; death receptor-associating protein; Lewis lung carcinoma; metastasis; TNF-alpha; tumorigenesis
Web of Science 学科类别Biochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Biophysics; BIOPHYSICS