Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 邓亮生教授 (化学病理学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1016/j.clinbiochem.2005.11.014 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/9WOS source URL
其它资讯
摘要Background: Single nucleotide polymorphisms (SNPs) are the most abundant kind of genetic polymorphism in the human genome. They are important in both genetic research and genetic testing in a clinical setting, such as in the area of pharmacogenetics. In order to improve efficiency, tagging SNPs (tagSNPs) are selected in genes of interest to represent other co-related SNPs in linkage disequilibrium (LD) with the tagSNPs. Various algorithms have been proposed to identify a subset of single nucleotide polymorphisms as tagSNPs. Most algorithms of tagSNPs selection are haplotype-based, in which the spatial relationship between SNPs is considered. Currently, a more efficient cluster-based algorithm is proposed which clusters SNPs solely by a LD parameter, such as r(2). Here, we evaluated the sample distribution of r(2) and its effect on the cluster-based tagSNPs selection.
着者Tang NLS, Pharoah PDP, Ma SL, Easton DF
期刊名称CLINICAL BIOCHEMISTRY
出版年份2006
月份3
日期1
卷号3http://aims.cuhk.edu.hk/converis/portal/Publication/9
期次3
出版社PERGAMON-ELSEVIER SCIENCE LTD
页次240 - 243
国际标準期刊号000http://aims.cuhk.edu.hk/converis/portal/Publication/9-http://aims.cuhk.edu.hk/converis/portal/Publication/9120
电子国际标準期刊号1873-2http://aims.cuhk.edu.hk/converis/portal/Publication/933
语言英式英语
关键词genetic; haplotype; LD metric; linkage disequilibrium; SNPs; tagging
Web of Science 学科类别Medical Laboratory Technology; MEDICAL LABORATORY TECHNOLOGY
