Refereed conference paper presented and published in conference proceedings
香港中文大学研究人员 ( 现职)
| 卢煜明教授 (化学病理学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1196/annals.1368.009 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/5WOS source URL
Scopushttp://aims.cuhk.edu.hk/converis/portal/Publication/10Scopus source URL
其它资讯
摘要The discovery of cell-free fetal DNA in maternal plasma has opened up new possibilities for noninvasive prenatal diagnosis. Most of the work in this field has focused on the detection of fetal genetic markers that are distinguishable from the background maternal DNA. The feasibility of detecting fetal epigenetic markers in maternal plasma using an imprinted locus was demonstrated in 2002. This work has recently led to the development of the first universal fetal epigenetic marker, hypomethylated maspin, which can be used for fetal DNA detection in maternal plasma, irrespective of fetal gender and genetic polymorphisms. It is expected that many more fetal epigenetic markers that can be used in this manner will be developed over the next few years. These markers may catalyze the eventual clinical use of circulating fetal DNA for noninvasive prenatal diagnosis, such as for the detection of fetal chromosomal aneuploidies. ? 2006 New York Academy of Sciences.
着者Lo Y.M.D.
出版年份2006
月份9
日期1
卷号http://aims.cuhk.edu.hk/converis/portal/Publication/107http://aims.cuhk.edu.hk/converis/portal/Publication/5
出版社New York Academy of Sciences
出版地United States
页次74 - 80
国际标準书号1http://aims.cuhk.edu.hk/converis/portal/Publication/57331627X
国际标準期刊号0077-8923
语言英式英语
关键词DNA methylation, Epigenetics, Noninvasive prenatal diagnosis
