Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 黄永坚教授 (儿科学系) |
| 林伟基教授 (化学病理学系) |
| 马淑玲教授 (精神科学系) |
| 李颂仪女士 (儿科学系) |
| 邓亮生教授 (化学病理学系) |
| 梁廷勋教授 (儿科学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1111/j.1399-3038.2006.00446.x |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/17WOS source URL
其它资讯
摘要Mannose-binding lectin (MBL), a member of the innate immune system, initiates complement deposition on microbial surfaces. MBL deficiency is associated with severe respiratory infections. Polymorphisms in the MBL gene (mbl2) were associated with the susceptibility and severity of autoimmune diseases. This study investigated whether mbl2 polymorphisms at positions -550 and -221 and at codon-54 are associated with asthma phenotypes in Chinese children. Asthmatics aged 5-18 yr and non-allergic controls were eligible, and their plasma total and allergen-specific immunoglobulin E (IgE) concentrations were measured by micro-particle immunoassay and fluorescent enzyme immunoassay. mbl2 polymorphisms were genotyped by restriction fragment length polymorphism. Three hundred and seventeen asthmatic children and 140 controls were recruited, with their mean (s.d.) log-transformed plasma total IgE being 2.61 (0.61) and 1.77 (0.77), respectively (p < 0.0001). Polymorphisms at -550 and codon-54 (p < 0.0001 for both) but not at -221 (p = 0.534) of mbl2 were significantly associated with plasma MBL concentrations. mbl2 genotypes were not associated with asthma, atopy, sensitization to individual aeroallergens or spirometric variable. Subjects with LYB haplotype had the lowest plasma MBL concentrations (p < 0.0001), but two- and three-loci mbl2 haplotypes were also not associated with asthma diagnosis. However, patients with LY and LYB haplotypes were less likely to be atopic (p = 0.006 and 0.031). Subjects with LY and LYA were also less likely to be sensitized to cockroach (p = 0.035 and 0.047). The latter three associations became insignificant when adjusted for multiple comparisons. Despite the importance of MBL in innate immunity, our mbl2 polymorphisms only show weak association with asthma and atopy in children.
着者Leung TF, Tang NLS, Sung YM, Li CY, Ma SL, Lam CWK, Wong GWK
期刊名称Pediatric Allergy and Immunology
出版年份2006
月份11
日期1
卷号http://aims.cuhk.edu.hk/converis/portal/Publication/17
期次7
出版社BLACKWELL PUBLISHING
页次501 - 507
国际标準期刊号0905-6157
电子国际标準期刊号1399-3038
语言英式英语
关键词asthma; atopy; Chinese; MBL; single nucleotide polymorphism
Web of Science 学科类别Allergy; ALLERGY; Immunology; IMMUNOLOGY; Pediatrics; PEDIATRICS
