Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 林伟基教授 (化学病理学系) |
| 黄永坚教授 (儿科学系) |
| 翁颂铭先生 (儿科学系) |
| 邓亮生教授 (化学病理学系) |
| 李颂仪女士 (儿科学系) |
| 梁廷勋教授 (儿科学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1038/sj.gene.6364279 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/35WOS source URL
其它资讯
摘要Human beta-defensin (HBD)-1 is constitutively expressed in the airway, and hBD-1 plays crucial roles in innate immunity against respiratory pathogens. Asthma was associated with DEFB1 polymorphisms in Caucasians. This study investigates whether three single nucleotide polymorphisms ( SNPs) in 5'-untranslated region of DEFB1 are associated with asthma phenotypes in Chinese children. Subjects aged 5-18 years were recruited from general pediatric clinics. Plasma IgE concentrations were measured by immunoassays. DEFB1 SNPs were characterized by restriction fragment length polymorphism. In all, 305 asthmatics and 156 controls were recruited. For asthma diagnosis, atopy and plasma total IgE, higher percentages of subjects with these outcomes had the minor alleles - 20A and - 52G ( P = 0.041 - 0.0002). For log-transformed total IgE, the covariate was positive and significant for G-20A under recessive model ( P = 0.001) and for G-52A under both recessive and codominant models ( P = 0.008 and 0.0http://aims.cuhk.edu.hk/converis/portal/Publication/35). The recessive model covariate was also positive and significant ( P = 0.020) for C-44G on peripheral blood eosinophil count. The GCA haplotype of DEFB1 was significantly associated with asthma ( odds ratio ( 95% confidence interval): 1.64 ( 1.05-2.57); P = 0.029). These results suggest that DEFB1 is a candidate gene for asthma and atopy in children.
着者Leung TF, Li CY, Liu EKH, Tang NLS, Chan IHS, Yung E, Wong GWK, Lam CWK
期刊名称Genes and Immunity
出版年份2006
月份1
日期1
卷号7
期次1
出版社NATURE PUBLISHING GROUP
页次59 - 64
国际标準期刊号1466-4879
语言英式英语
关键词asthma; atopy; defensin; immunoglobulin E; innate immunity; polymorphism
Web of Science 学科类别Genetics & Heredity; GENETICS & HEREDITY; Immunology; IMMUNOLOGY
