Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 卢煜明教授 (化学病理学系) |
| 古明达教授 (矫形外科及创伤学系) |
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Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/8WOS source URL
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摘要Musculoskeletal allotransplantion is the most common form of human tissue transplantation. Unlike solid organ transplants, bone allotransplants undergo rigorous processing and are considered non-viable tissue. In this study, we propose that donor genetic material may exist in circulation after bone allotransplantation. Fifty-one female patients who received bone allotransplants from male donors were assessed. Blood plasma samples were analyzed using realtime quantitative polymerase chain reaction (PCR) with dual labeled fluorogenic probes for the presence of the SRY gene on the Y chromosome. Of the total 51 patients, the SRY sequence was detected in 6 patients. Five were positive at day 1 postoperatively and negative thereafter, with the remaining patient positive at 3 months post-transplantation. Our results document, for the first time, the presence of donor DNA in the circulation of recipients after bone allotransplantation. Our findings suggest a potential new investigative tool to assess the postoperative status of bone allotransplants.
着者Partsalis T, Chan LYS, Hurworth M, Willers C, Pavlos N, Kumta N, Wood D, Xu J, Kumta S, Lo YMD, Zheng MH
期刊名称International Journal of Molecular Medicine
出版年份2006
月份6
日期1
卷号17
期次6
出版社PROFESSOR D A SPANDIDOS
页次1151 - 1155
国际标準期刊号1107-3756
电子国际标準期刊号1791-244X
语言英式英语
关键词allograft; allotransplantation; SRY gene
Web of Science 学科类别Medicine, Research & Experimental; MEDICINE, RESEARCH & EXPERIMENTAL; Research & Experimental Medicine
