Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 卢煜明教授 (化学病理学系) |
| 赵慧君教授 (化学病理学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1196/annals.1318.016 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/13WOS source URL
其它资讯
摘要It has been several years since the presence of fetal DNA in maternal plasma was first discovered. Numerous potential applications have been reported to date. However, the study of maternal plasma for the prenatal diagnosis of fetal genetic traits has largely centered on paternally inherited autosomal dominant traits. Recently, a number of approaches have been developed that allow the prenatal assessment of autosomal recessive conditions through fetal DNA analysis in maternal plasma. On the other hand, aberrations in fetal DNA concentrations in maternal plasma have been reported in a number of pregnancy-associated conditions. Recent studies have begun to address the possible underlying mechanisms causing such quantitative aberrations. Current studies on circulating fetal DNA have focused on the detection of the paternally inherited fetal-specific alleles in maternal plasma. However, it has been demonstrated that the development of fetal epigenetic markers has great potential to expand the field.
着者Chiu RWK, Lo YMD
会议名称3rd International Symposium on Circulating Nucleic Acids in Plasma/Serum (CNAPS III) and Serum Proteomics
会议开始日09.11.2003
会议完结日12.11.2003
会议地点Santa Monica
期刊名称Annals of the New York Academy of Sciences
出版年份2004
月份1
日期1
卷号1022
出版社NEW YORK ACAD SCIENCES
页次100 - 104
国际标準书号1-57331-551-6
国际标準期刊号0077-8923
电子国际标準期刊号1749-6632
语言英式英语
关键词fetal DNA; maternal plasma; paternally transmitted alleles; prenatal diagnosis
Web of Science 学科类别Biochemistry & Molecular Biology; Medical Laboratory Technology; Medicine, Research & Experimental; Multidisciplinary Sciences; Oncology; Research & Experimental Medicine; Science & Technology - Other Topics
