Cell-free DNA and RNA in plasma as new tools for molecular diagnostics
Publication in refereed journal


香港中文大学研究人员 ( 现职)

卢煜明教授 (化学病理学系)

全文

数位物件识别号 (DOI) http://dx.doi.org/10.1586/14737159.3.6.785

引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/19WOS source URL

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摘要The recent interest in plasma nucleic acids has opened up many new promising possibilities for the noninvasive detection and monitoring of a variety of diseases. The discovery of tumor-derived DNA in the plasma of cancer patients has provided an alternative method for cancer detection, monitoring and prognostication, whereas the presence of fetal DNA in maternal plasma has revealed significant clinical potential for the prenatal diagnosis of fetal genetic diseases and pregnancy-associated complications. Further applications have been reported in transplantation, traumatology and acute medicine. Extending beyond plasma DNA, a new field of investigation has also been developed in the analysis of plasma RNA, which holds promise for noninvasive gene expression profiling. Biologically, future work will focus on the elucidation of the origin and clearance of circulating DNA, as well as the unexpected stability of circulating RNA.

着者Wong BCK, Lo YMD
期刊名称Expert Review of Molecular Diagnostics
出版年份2003
月份11
日期1
卷号3
期次6
出版社FUTURE DRUGS LTD
页次785 - 797
国际标準期刊号1473-7159
电子国际标準期刊号1744-8352
语言英式英语

关键词cancer detection; noninvasive plasma DNA; plasma RNA; prenaral diagnosis; real-time quantitative PCR; reverse transcriptase PCR
Web of Science 学科类别Pathology; PATHOLOGY