Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 卢煜明教授 (化学病理学系) |
| 赵慧君教授 (化学病理学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1016/S0070-2153(04)61004-0 |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/28WOS source URL
其它资讯
摘要As conventional methods for prenatal diagnosis, such as amniocentesis and chorionic villus sampling, are associated with a risk of fetal loss, the pursuit of safe noninvasive alternatives has been a long-sought goal in medicine. The discovery of the presence of extracellular fetal nucleic acids in the maternal circulation has offered new avenues for the realization of this goal. The number of potential applications of fetal nucleic acids analysis from maternal plasma has grown substantially in recent years. Noninvasive prenatal rhesus D genotyping has been introduced into routine use by some centers. Although certain limitations are preventing the wider adoption of circulating fetal nucleic acids analysis for clinical use, promising developments with the potential to overcome the present limitations have emerged recently. Albeit the rapid growth in the number of potential applications, much work is required to elucidate the little-known physiological mechanisms of circulating fetal nucleic acid release and clearance. Furthermore, in recent years, there is a greater appreciation of the impact of certain technical factors on the interpretation of research data on circulating fetal nucleic acids. Further rapid development in this emerging area is expected over the next few years. (C) 2004, Elsevier Inc.
着者Chiu RWK, Lo YMD
期刊名称Current Topics in Developmental Biology
出版年份2004
月份1
日期1
卷号61
出版社ELSEVIER ACADEMIC PRESS INC
页次81 - 111
国际标準期刊号0070-2153
语言英式英语
Web of Science 学科类别Developmental Biology
