Publication in refereed journal
香港中文大学研究人员 ( 现职)
| 霍泰辉教授 (儿科学系) |
| 黄永坚教授 (儿科学系) |
| 翁颂铭先生 (儿科学系) |
| 林伟基教授 (化学病理学系) |
| 李颂仪女士 (儿科学系) |
| 梁廷勋教授 (儿科学系) |
全文
| 数位物件识别号 (DOI) http://dx.doi.org/10.1111/j.1399-3038.2004.00164.x |
引用次数
Web of Sciencehttp://aims.cuhk.edu.hk/converis/portal/Publication/56WOS source URL
其它资讯
摘要Epidemiologic studies suggest increased asthma prevalence in obese subjects. However, the relation between obesity and airway inflammation remains unclear. This cross-sectional study aims to investigate the relation between obesity indices and exhaled nitric oxide (ENO) and leukotriene B-4 (LTB4) in children with asthma. Asthmatic patients aged 7-18 yr old were recruited. Weight-for-height Z score was calculated from anthropometry. ENO was measured by online single-breath method using a chemiluminescence analyzer, whereas LTB4 concentrations in exhaled breath condensate (EBC) were quantified using competitive enzyme immunoassay. Ninety-two asthmatics and 23 controls were recruited. The mean ENO and LTB4 concentrations in EBC were higher in asthmatic patients (87 p.p.b. and 40.5 pg/ml) than controls (25 p.p.b. and 18.7 pg/ml) (p < 0.0001 for both). Obesity, as defined by weight >120% median weight-for-height, was not associated with any alteration in ENO or LTB4 concentrations in patients with asthma. Besides, these inflammatory markers did not differ between asthmatics in the highest and lowest quartiles of weight-for-height Z score. On multivariate analysis, ENO showed significant correlation with age (beta = 0.511, p < 0.0001), peripheral blood eosinophil count (beta = 0.222, p = 0.019), plasma total IgE concentration (beta = 0.187, p = 0.050) and forced expiratory volume in 1-s (FEV1; beta = -0.221, p = 0.014). None of the factors was associated with LTB4 concentration in EBC. In conclusion, ENO and LTB4 concentration in EBC are increased in childhood asthma. However, these inflammatory markers did not differ between obese and non-obese children with asthma.
着者Leung TF, Li CY, Lam CWK, Au CSS, Yung E, Chan IHS, Wong GWK, Fok TF
期刊名称Pediatric Allergy and Immunology
出版年份2004
月份8
日期1
卷号15
期次4
出版社BLACKWELL MUNKSGAARD
页次344 - 350
国际标準期刊号0905-6157
电子国际标準期刊号1399-3038
语言英式英语
关键词asthma; breath condensate; exhaled nitric oxide; leukotriene B-4; obesity
Web of Science 学科类别Allergy; ALLERGY; Immunology; IMMUNOLOGY; Pediatrics; PEDIATRICS
