中山大学医学院教授、博导，国家****基金获得者，国家“973”计划首席科学家，国家“****”领军人才，广东省“珠江人才计划”领军人才。中国微生物学会病毒学专业委员会主任委员，科技部人才推进计划重点领域创新团队负责人。主要研究RNA病毒的感染免疫与致病机制以及防治策略，近年来的主要研究内容包括：RNA病毒基因组复制机制、病毒感染免疫调控机理、病毒RNA甲基化修饰与免疫逃逸机制以及RNA病毒控制新策略，发现了RNA病毒基因组修饰以及干细胞抗病毒免疫等一系列新机制，在Nature Immunology、 Cell?Research、Hepatology、PNAS、PLoS Pathogens、 Journal of Virology、Journal of Immunology等国内外学术期刊发表相关SCI论文130余篇，国家授权专利七项。
研究方向：RNA病毒感染致病机制与免疫调控机理，冠状病毒RNA甲基化修饰与免疫逃逸，抗病毒药物筛选和溶瘤病毒靶向治疗。
招生学科专业：071000 生物学-05 微生物学，086000 生物与医药。
邮箱：guodeyin@mail.sysu.edu.cn
著作1. Panpan Hou#, Penghui Jia#, Kongxiang Yang#, Zibo Li, Tian Tian, Yuxin Lin, Weijie Zeng, Fan Xing, Yu Chen, Chunmei Li, Yingfang Liu & Deyin Guo*，An unconventional role of an ASB family protein in NF-κB activation and inflammatory response during microbial infection and colitis，Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e.
2. Yingjun Li#, Liu Cao#, Ge Li, Feng Cong, Yunfeng Li, Jing Sun, Yinzhu Luo, Guijiang Chen, Guanguan Li, Ping Wang, Fan Xing, Yanxi Ji, Jincun Zhao, Yu Zhang*, Deyin Guo*, Xumu Zhang*. (2021) Journal of Medicinal Chemistry?2021 Feb 1. doi: 10.1021/acs.jmedchem.0c01929.
3. Panpan Hou#, Kongxiang Yang, Penghui Jia, Lan Liu, Yuxin Lin, Zibo Li, Jun Li, Shuliang Chen, Shuting Guo, Ji’An Pan, Junyu Wu, Hong Peng, Weijie Zeng, Chunmei Li, Yingfang Liu and Deyin Guo*，A novel selective autophagy receptor, CCDC50, delivers K63 polyubiquitination-activated RIG-I/MDA5 for degradation during viral infection，Cell Res. 2021 Jan;31(1):62-79.
4. Yun-Yun Jin, Hanwen Lin, Liu Cao, Wei-Chen Wu, Yanxi Ji, Liubing Du, Yiling Jiang, Yanchun Xie, Kuijie Tong, Fan Xing, Fuxiang Zheng, Mang Shi, Ji-An Pan, Xiaoxue Peng*, Deyin Guo*. (2021) A convenient and biosafe replicon with accessory genes of SARS-CoV-2 and its potential application in antiviral drug discovery.?Virologica Sinica?(in press)
5. Yu Chen*, Qianyun Liu & Deyin Guo*?(2020) Emerging coronaviruses: Genome structure, replication, and pathogenesis. J Med Virol. 2020 Apr;92(4):418-423. doi: 10.1002/jmv.25681. Epub 2020 Feb 7.
6. Liping Guo#, Xiaoyu Lu#, Xue Liu, Ping Li, Junyu Wu, Fan Xing, Hong Peng, Xiaojun Xiao, Mang Shi, Zhigang Liu, Xiao-Dong Li*, Deyin Guo*?(2020) Meta-transcriptomic analysis reveals the virome and viral genomic evolution of medically important mites. J Virol. 2020 Nov 18; JVI.01686-20. ?doi: 10.1128/JVI.01686-20.
7. Shibo Jiang, Zhengli Shi, Yuelong Shu, Jingdong Song, George F Gao, Wenjie Tan, Deyin Guo*?(2020) A distinct name is needed for the new coronavirus.?Lancet. 2020 Mar 21;395(10228):949. doi: 10.1016/S0140-6736(20)30419-0. Epub 2020 Feb 19.
8. Liu Cao#, Yanxi Ji, Lanyi Zeng, Qianyun Liu, Zhen Zhang, Shuting Guo , Xiaolong Guo , Yongjia Tong, Xiaolu Zhao , Chun-Mei Li, Yu Chen*, Deyin Guo*，?P200 family protein IFI204 negatively regulates type I interferon responses by targeting IRF7 in nucleus，PLoS Pathog.?2019 Oct 11;15(10):e**. ?doi: 10.1371/journal.ppat.**. eCollection 2019 Oct.
9. Jingwen Wang#, Jianwen Chen, Yang Liu, Xianhuang Zeng , Mingcong Wei, Shaoshuai Wu, Qiushuang Xiong, Feifei Song, Xu Yuan, Yu Xiao, Yun Cao, Changyong Li, Lang Chen , Mingxiong Guo, Yun-Bo Shi, Guihong Sun*, Deyin Guo*?Hepatitis B Virus Induces Autophagy to Promote its Replication by the Axis of miR-192-3p-XIAP Through NF kappa B Signaling，Hepatology. 2019 Mar;69(3):974-992. ?doi: 10.1002/hep.30248.
10. Dan Liu#, Lei Cui, Yuan Wang, Guifang Yang, Ruidong Hao, Jing He, Chengpeng Fan, Mengmeng Qu, Zhepeng Liu, Min Wang, Lang Chen and Deyin Guo* (2016) HBV e antigen and its precursors promote the progress of hepatocellular carcinoma by interacting with NUMB and decreasing p53 stability and activity. Hepatology 64, 390-404. 2016 Apr 22. doi: 10.1002/hep.28594.?
11. Shun Li#, Mingzhu Zhu, Ruangang Pan, Ting Fang, Yuan-Yuan Cao, Shuliang Chen, Xiaolu Zhao, Cao-Qi Lei, Lin Guo, Yu Chen, Chunmei Li, Eija Jokitalo, Yuxin Yin, Hong-Bing Shu, Deyin Guo* (2016) The tumor suppressor PTEN has a critical role in antiviral innate immunity. Nature Immunology 17, 241-249.
12. Yu Chen#, Hui Cai, Ji’an Pan, Nian Xiang, Po Tien, Tero Ahola, Deyin Guo*?(2009) Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase. Proceedings of the National Academy of Sciences of the United States of America 106, 3484-9.
13. Yu Chen#, Ceyang Su#, Min Ke, Xu Jin, Lirong Xu, Zhou Zhang, Andong Wu, Ying Sun, Zhouning Yang, Po Tien, Tero Ahola, Yi Liang, Xinqi Liu*, Deyin Guo*?(2011) Biochemical and structural insights into the mechanisms of SARS coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex. PLoS Pathogens 7(10): e**. doi:10.1371/journal.ppat.**.
14. Yi Wang#, Ying Sun#, Andong Wu, Shan Xu, Ruangang Pan, Cong Zeng, Xu Jin, Xingyi Ge, Zhengli Shi, Tero Ahola, Yu Chen*, Deyin Guo*?(2015) Coronavirus nsp10/nsp16 methyltransferase can be targeted by nsp10-derived peptide in vitro and in vivo to reduce replication and pathogenesis. Journal of Virology 89, 8416-27.
15. Cong Zeng#, Andong Wu, Yi Wang, Shan Xu, Yingke Tang, Xu Jin, Shilei Wang, Lei Qin, Ying Sun, Chengpeng Fan, Eric J. Snijder, Benjamin W. Neuman, Yu Chen,Tero Ahola and Deyin Guo*?(2016) Identification and Characterization of a Ribose 2'-O-Methyltransferase Encoded by the Ronivirus Branch of Nidovirales. Journal of Virology 90(15):6675-85.
16. Lei Cui#, Haiying Wang, Yanxi Ji, Jie Yang, Shan Xu, Xingyu Huang, Zidao Wang, Lei Qin, Po Tien, Xi Zhou, Deyin Guo*, Yu Chen* (2015) The nucleocapsid protein of coronaviruses acts as a viral suppressor of RNA silencing in mammalian cells. Journal of Virology 89, 9029-43.
17. Yu Chen#, Jiali Tao, Ying Sun, Andong Wu, Ceyang Su, Guozhen Gao, Hui Cai, Su Qiu, Yingliang Wu, Tero Ahola, Deyin Guo*?(2013) Structure-function analysis of SARS coronavirus RNA cap guanine-N7 methyltransferase. Journal of Virology 87, 6296-305.
研究方向RNA病毒感染致病机制与免疫调控机理，冠状病毒RNA甲基化修饰与免疫逃逸，抗病毒药物筛选和溶瘤病毒靶向治疗
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